1. The Statistical Consulting Collaboration Center & You Guy Brock SPHIS / SON Research Summit 11/13/09 11/13/20091 Guy Brock, StCC

2. Doug Lorenz, MS Doug Lorenz, MS Alex Cambon, MS Alex Cambon, MS Savi Appana, MS Savi Appana, MS Guy Brock, PhD, Director Guy Brock, PhD, Director StCC Current Members 11/13/20092Guy Brock, StCC

3. Current Goals To build collaborative relationships with investigators throughout the HSC (and UofL in general) to conduct innovative studies and engage in thorough, sophisticated analysis with groundbreaking results To build collaborative relationships with investigators throughout the HSC (and UofL in general) to conduct innovative studies and engage in thorough, sophisticated analysis with groundbreaking results –Will settle for fundable and publishable 11/13/20093Guy Brock, StCC

4. How do we accomplish this? Key to success – build strong collaborative relationships Key to success – build strong collaborative relationships –You build off our strengths, we build off yours, and we share ideas Need grant submissions to support % effort and RIF to make this a reality Need grant submissions to support % effort and RIF to make this a reality 11/13/20094Guy Brock, StCC

5. Study Design & Development Study Design & Development Analysis & Modeling Analysis & Modeling Dissemination of Results Dissemination of Results Our Expertise 11/13/20095Guy Brock, StCC

6. Design studies, protocol development Design studies, protocol development Frame research questions Frame research questions Develop data collection instruments Develop data collection instruments Compute sample sizes and conduct power analyses Compute sample sizes and conduct power analyses Write statistical analysis plans Write statistical analysis plans Study Design & Development 11/13/20096Guy Brock, StCC

7. Descriptive statistics and simple hypothesis testing Descriptive statistics and simple hypothesis testing Categorical data analysis Categorical data analysis Linear, generalized linear, and mixed effects models Linear, generalized linear, and mixed effects models Survival analysis Survival analysis Multivariate and longitudinal data Multivariate and longitudinal data Exploratory data analysis (clustering techniques, tree-based model fitting) Exploratory data analysis (clustering techniques, tree-based model fitting) Bioinformatics, statistical genetics Bioinformatics, statistical genetics Analysis & Modeling 11/13/20097Guy Brock, StCC

8. Scientific reports and Manuscript preparation Scientific reports and Manuscript preparation –Methods, Results, Discussion Publication quality Tables and Graphs Publication quality Tables and Graphs Dissemination of Results 11/13/20098Guy Brock, StCC

9. How we support ourselves GRANTS!! GRANTS!! –Grant development free of charge, provided adequate % effort on grant Fee for service (less attractive) Fee for service (less attractive) –hourly basis –Initial consultation is free –Walk-in clinic from 10-12 every Friday is free of charge 11/13/20099Guy Brock, StCC

10. StCC Policies Co-author inclusion irrespective of support mechanism Co-author inclusion irrespective of support mechanism Full statement of policies at http://louisville.edu/sphis/bb/stcc Full statement of policies at http://louisville.edu/sphis/bb/stcc http://louisville.edu/sphis/bb/stcc 11/13/200910Guy Brock, StCC

11. Examples of Collaborations Community-Acquired Pneumonia Community-Acquired Pneumonia Transplantation / Liver Disease Transplantation / Liver Disease Oncology / Surgery Oncology / Surgery Cancer Genetics Cancer Genetics 11/13/200911Guy Brock, StCC

12. Community-Acquired Pneumonia 11/13/200912Guy Brock, StCC

13. Transplantation / Liver Disease 11/13/200913Guy Brock, StCC

14. Oncology / Surgery 11/13/200914Guy Brock, StCC

15. A Possibility to Get Started Utilize existing (publicly available) databases Utilize existing (publicly available) databases –Many grant mechanisms support secondary data analysis –R15, R21, R03, Robert Wood Johnson Foundation Use these to provide prelim results to support other grant submissions Use these to provide prelim results to support other grant submissions 11/13/200915Guy Brock, StCC

16. Catalysts for Research Ideas 11/13/200916Guy Brock, StCC

17. Thank you 11/13/200917 Guy Brock, StCC