1. Evaluation of two years of residential care treatment for early-onset schizophrenia / M. J. Hemmerle 1,2, B. Röpcke 1,2, C. Eggers 1,2, R. D. Oades 1 Evaluation of two years of residential care treatment for early-onset schizophrenia www.eggers-stiftung.de / www.biopsychology.uni-essen.de M. J. Hemmerle 1,2, B. Röpcke 1,2, C. Eggers 1,2, R. D. Oades 1 m.hemmerle@eggers-stiftung.de www.eggers-stiftung.de www.biopsychology.uni-essen.de m.hemmerle@eggers-stiftung.de Social function: Global Assessment of Function Scale** Psychopathology: PANSS/SANS & SAPS** Negative Symptoms Positive Symptoms BioPsychology Research Group, Psychiatry Clinics, University of Duisburg-Essen, D-45147 Essen (1), Eggers-Foundation, Alexanderstraße 23, D-45130 Essen (2) Neuropsychology: Estimated effects and 95% confidence bounds of AOS reference values (Hedges´ unbiased g) T R I A L O G U E Provides pedagogic – therapeutic intensive care residential group for adolescents and young adults suffering from schizophrenia Integrate communication: "family-patient- professional"-Trialogue Community centred 8 residents Multi-professional Team Close co-operation with psychiatric Clinic Ratio nurse/affected 1:1 24 hours attendance Residence limited to 2 years Methods and results: Positive and Negative Syndrome Scale (PANSS) & Scales for the Assessment of Negative/Positive Symptoms (SANS & SAPS)** Global Assessment of Function Scale (GAF)** Clinical Global Impression (CGI)** Manchester Short Assessment of the Quality of Life (MANSA, German version) [see example in figure below] Hamburg-Wechsler Intelligence Test for adults /revised (HAWIE-R) (Information, Arithmetic, Digit-Symbol-Test T *, Block- design*, Digit Span) Trail Making Test (TMT-A*, -B T *) Word Fluency (FAS)* Wechsler Memory Scale-Revised (WMS-R, delayed reproduction**) * : Significant improvement of Trialogue (p <.05) T : Trend (p <.1) *: Significant interaction of groups and assessments showing an advantage of Trialogue (p <.05) T : Trend (p <.1) Sample: Trialogue: 12 Trialogue residents with 2 years of intensive care Diagnosis: 10 Schizophrenic disorder (ICD-10: F20); 2 Schizoaffective disorder (ICD-10: F25) Assessment time points: T1: On entry to Trialogue T3: When leaving Trialogue Comparison Group: 12 adolescents admitted consecutively to the clinic with Early Onset Schizophrenia (EOS: ICD-10: F20) Assessment time points: T1: At discharge T3: Catamnesis after 3 years Selection towards more impaired patients for Trialogue: More re-admissions, more restricted socioeconomic resources, more co-morbid disorders, more impaired neuropsychological performance, longer duration of untreated psychosis (reflecting more insidious onset) Summary and Conclusions Implementation of community centred intense early care of EOS patients over 2 years is effective at improving function in psychopathological, social, and neuropsychological areas of function at the time the patients leave. Special residential care for a limited time can be recommended, especially for those who do not find regular activity following clinical discharge. Such a programme should ideally be associated with special educational facilities and linked to early detection and treatment centres. Regular activity at T3* Residential Conditions at T3* Quality of live: Subjective contentedness with relations to family* content Not content