1. National Alliance for Medical Image Computing http://na-mic.org Core 3-1 Schizophrenia NA-MIC National Alliance for Medical Image Computing http://na-mic.org Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School Surgical Planning Laboratory, MRI Division, Department of Radiology Brigham & Women’s Hospital, Harvard Medical School

2. National Alliance for Medical Image Computing http://na-mic.org Data All the legacy data has been converted to one single file format, nrrd. Total of 188 morphological cases and 80 diffusion cases have been uploaded. Each case has a unique BIRN identifier. Information about diagnosis, data parameters and labels associated with Region of Interests (ROI) are on the BIRN site in the following Excel files: - morph-NAMIC.xls : Gives diagnosis, age, gender as well as the ROIs drawn for each morphological case. - morph-ROI-description.xls: Gives for each ROI set, the label corresponding to specific structures. - diffusion-NAMIC.xls: Gives diagnosis, age, gender, ROIs drawn and when existing, the corresponding morphological data ID number. - diffusion-ROI-description.xls: Gives or each ROI set, the label corresponding to specific structures.

3. National Alliance for Medical Image Computing http://na-mic.org Data Sets Already Uploaded MRI Data: Raw SPGR (124 slices of 1.5 mm thickness, voxel dimensions 0.9375 x 0.9375 x 1.5 mm): (N=26 SZ; N=28 AFF; N=29 Ctrl). ROIs -Amygdala-Hippocampus: (N=16 SZ and N=15 Ctrl). -STG: (N=17 SZ; N=16 AFF; N=18Ctrl). -MTG & ITG: (N=23 SZ; N=28 Ctrl). -Caudate: (N=15 SPD; N=14 Ctrl). -Insular Cortex & Temporal Pole: (N=26 SZ; N=28 AFF; N=29 Ctrl). DTI Data: Raw DWI data (8 images- six gradient directions plus 2 T2W, FOV 220mm, 256 x 256 image matrix, 4 mm slice thickness, 1 mm interslice distance). ROIs -Cingulum Bundle: (N=31 SZ; N=42 Ctrl). -Fornix: (N=24 SZ; N=31 Ctrl).

4. National Alliance for Medical Image Computing http://na-mic.org MRI Data

5. National Alliance for Medical Image Computing http://na-mic.org STG, MTG, and ITG Segmented ROIs (Onitsuka et al., AJP In Press)

6. National Alliance for Medical Image Computing http://na-mic.org (Kasai et al., Arch Gen Psychiatry, 2003) Insular Cortex and Temporal Pole ROI

7. National Alliance for Medical Image Computing http://na-mic.org Caudate Nucleus ROI (Koo et al., In Preparation)

8. National Alliance for Medical Image Computing http://na-mic.org DTI Data

9. National Alliance for Medical Image Computing http://na-mic.org Cingulum Bundle ROI was drawn on 8 consecutive slices. The fiber tract is much longer, however, but not easy to delineate. (Kubicki et al., 2003)

10. National Alliance for Medical Image Computing http://na-mic.org Fornix ROI drawn on 1slice perpendicular to the plane. (Kuroki et al., in press)

11. National Alliance for Medical Image Computing http://na-mic.org Rules for accessing and using the data IRB training (human subject’s protection) Data sharing (do not give data to other people) ROI data publication acknowledgement Grant acknowledgement -NIGHS/NI - U54 GM 072977 to Ron Kikinis -NIH - P41 RR13218 to Ron Kikinis; RO1 NS39335 to Stephan Maier; R01 MH 50747 to Martha Shenton; K05 MH 70047 to Martha Shenton; R01 MH 40799 to Robert McCarley; R03 MH 068464 to Marek Kubicki. -VA- Merit Awards to Martha Shenton and to Robert McCarley and a Research Enhancement Award Program (VA REAP) to Robert McCarley and to Martha Shenton.