1. New Progresses of DTI-Map, a Program for DTI Computation and Fiber Tracking Hangyi Jiang, Peter van Zijl, Susumu Mori Dept. of Radiology Johns Hopkins University School of Medicine F.M. Kirby Research Center for Functional Brain Imaging

2. All-in-One Strategy  Integrating DTI computation, fiber tracking, 3D visualization, ROI drawing and statistic analysis all together;  Windows-style programming with user- friendly interface, most operations could be done just by few clicks;

3. Facility in Variety of Scanners Philips Siemens GE Raw data etc.

4. Imaging Parameter Dialog  Smart dialogs for parameters input and verification  More options for better visualization or computation efficiency  Gradient table editor are introduced

5. DTI computation: one-click solution DTI computation, Color Mapping, Anisotropy analysis, ADC map, fiber tracking etc. can be finished in few minutes just by one click

6. DTI Computation: tensor matrix Dyy Dxx Dzz Dxz Dyz Dxy Dzy Dzx Dyx

7. DTI Computation: other-results Eigen ValuesEigen VectorsColor Maps FA VR RA Primary Axis 2nd Axis Shortest Axis xyz xyz xyz Anisotropy

8. DTI Computation: ADC map Original Images (Multi-Scans) ADC Map for every gradient

9. Region of Interesting (ROI) Tools  Built-in ROI tools  Variety drawing tools, 3D ROI displaying, ROI combination makes complex-ROI drawing possible  Statistic analysis within ROIs for orthogonal views  ROI file management is available

10. ROI Tools: Interface Statistics Shapes Operations Files Options

11. ROI Drawing Tools Rectangle Polygon Ellipse  Multiple-ROI:  Multiple Slices ROI (3D ROI): Slice 120 Slice 121 Slice 123 Slice 124 ROI (Region Of Interesting) drawing tools  Different Shape:

12. Multiple ROIs operations ROI - A ROI - B Combination A + B A x B A - B AND OR NOT Original Result

13. Fiber Tracking  Fiber tracking can be finished in a few minutes  Fiber selection by multi-ROIs combination  Visualization in 2D or 3D views  Fiber data file management is available

14. Fiber Tracking: Interface ROI combination Fiber selection Fiber color assignment ROI shape display options Fiber-ROI files Fiber-ROI statistics File commands

15. Fiber Tracking: visualization Selected tracts can be displayed in 3D and 2D orthogonal views simultaneously using user assigned color.

16. Fiber Tracking: visualization Selected tracts can also be displayed in 2D multi-slices mode.

17. Fiber Selection: by ROI combination Fiber can be selected by multi-ROIs combinations such as AND, OR and NOT. This example shows the fibers passing through ROI-A but not ROI-B ROI - A ROI - B

18. Fiber Selection: more details Q: Why do we need it? A: Select (and visualize) the interested fibers within the whole fiber data record  Intersection (AND)  Union (OR) ROI - A ROI - B ROI - A ROI - B  Exclusion (NOT) ROI - A ROI - B A  B A  B A - B

19. Fiber Tracking: Algorithm Basically, the algorithm is on FACT method (Mori et al, 1999) Tracking starts when FA > threshold Tracking stops when FA < threshold or tract changed its direction sharply >70º FA < 0.4

20. Visualization  Visualizing images in 2D-orthogonal views and 3D view  3D viewing direction changing freely  Zoom in, zoom out interactively for 3D view  Multi-slices image viewing, image scaling, image data and profile viewing are available

21. Visualization: 3D and 2D views Axial View Coronal ViewSagittal View 3D View

22. Visualization: image level adjusting Image level adjusting helps the users viewing the details more

23. Visualization: 3D view  3D-visualization : – Interactively rotating, zooming and so on. – Slice opacity is adjustable – User-defined fiber color – Synchronized with the 2D orthogonal slice views

24. Visualization: 3D image opacity Adjustable image opacity makes see-through possible