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Lymph node pathology.

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Presentation on theme: "Lymph node pathology."— Presentation transcript:

1 Lymph node pathology

2 Lymph node histology Functions Filtration of lymph Processing of Ag
Differentiation of lymphocytes

3 Secondary lymphoid follicle
Germinal centre mantle

4 Terminology Lymphadenopathy Lymphadenomegaly Lymphadenitis
Lymphoproliferation Lymphoma Enlargement of LN: inflammation Tumor – primary/secondary

5 Lymphadenitis acute or chronic
Rarely biopsied Classification predominant histologic pattern etiology

6 Lymphadenitis - etiology
MICROBIAL viral bacterial, mycobacterial fungal protozoal NONMICROBIAL - autoimmune storage dis. foreign mat. miscel.

7 Lymph node inflammation
Lymph node hyperplasia: 1. follicular 2. paracortical 3. sinuses 4. mixed patterns

8 Lymph node inflammation - patterns
Follicular hyperplasia bacteria, RA, HIV(early), syphilis, Castleman dis. Paracortical hyperplasia viruses, dermatopathies, vaccination, drug hypersensitivity, Kikuchi, SLE, draining pus or carcinoma

9 Lymphadenitis - histological patterns
sinusoidal hyperplasia - lymphangiography, Whipple dis., sin. histiocytosis with massive lymphadenopathy, draining carcinoma granulomas - TB, other mycobact., leprosy, Whipple, fungi, berylliosis, sarcoidosis, Granulomatous-purulent:cat scratch, tularemia, lymphogr. venereum,Yersinia mixed patterns: toxoplasmosis

10 Regressive transformation of germinal centres

11 Follicular hyperplasia

12 Progressive transformation of germianl centres

13 Sinus histiocytosis

14 Lepra - globi

15 Infectious mononucleosis

16 Cat scratch disease

17 Kikuchi lymphadenitis

18 Bartonella henselae Ct scratch disease

19 CMV

20 Kimura disease

21 Cryptococcosis

22 Atypical mycobacteriosis

23 Lymphogranuloma venereum

24 Mycobacterium TB

25 Pneumocystosis

26 Syphilis

27 TBC

28 Toxoplasmosis

29 Whipple disease

30 Sinus histiocytosis with massive lymphadenopathy

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