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Lymph node pathology
Lymph node histology Functions Filtration of lymph Processing of AgDifferentiation of lymphocytes
Secondary lymphoid follicleGerminal centre mantle
Terminology Lymphadenopathy Lymphadenomegaly LymphadenitisLymphoproliferation Lymphoma Enlargement of LN: inflammation Tumor – primary/secondary
Lymphadenitis acute or chronicRarely biopsied Classification predominant histologic pattern etiology
Lymphadenitis - etiologyMICROBIAL viral bacterial, mycobacterial fungal protozoal NONMICROBIAL - autoimmune storage dis. foreign mat. miscel.
Lymph node inflammationLymph node hyperplasia: 1. follicular 2. paracortical 3. sinuses 4. mixed patterns
Lymph node inflammation - patternsFollicular hyperplasia bacteria, RA, HIV(early), syphilis, Castleman dis. Paracortical hyperplasia viruses, dermatopathies, vaccination, drug hypersensitivity, Kikuchi, SLE, draining pus or carcinoma
Lymphadenitis - histological patternssinusoidal hyperplasia - lymphangiography, Whipple dis., sin. histiocytosis with massive lymphadenopathy, draining carcinoma granulomas - TB, other mycobact., leprosy, Whipple, fungi, berylliosis, sarcoidosis, Granulomatous-purulent:cat scratch, tularemia, lymphogr. venereum,Yersinia mixed patterns: toxoplasmosis
Regressive transformation of germinal centres
Progressive transformation of germianl centres
Lepra - globi
Cat scratch disease
Bartonella henselae Ct scratch disease
Sinus histiocytosis with massive lymphadenopathy
CHRONIC (AND GRANULOMATOUS) INFLAMMATION
Imaging Mimics of Lymphoma on PET/CT
Lymphadenopathy in Children
Lymphomas of the Head and Neck
Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology West China Medical school of Sichuan University.
Lymphadenopathy Surapon Wiangnon. References Ferrer R. Lymphadenopathy: Differential Diagnosis and Evaluation. American Family Physician October 15, 1998.
Lymphadenopathy and Malignancy Andrew W.Bazemore, M.D., and Douglars R. Smucker, M.D., M.P.H. University of Cincinnati College of Medicine, Cincinnati,
Lymphoid System Dr. Raid Jastania Dec, By the end of this session you should be able to: –Describe the components of the lymphoid system –List the.
Kikuchi-Fujimoto Disease Masquerading as Metastatic Papillary Carcinoma of the Thyroid Manuel Villa, MD 1, Shailesh Garg, MD 1, Thomas Mathew, MD 1, Louis-Joseph.
A lump in the neck. Case 1 A 55yr old man presents to his GP with a progressively enlarging lump at the side of his neck by his jaw. What are the possible.
Approach to Lymphadenopathy
DR.FAROOQ ALAM M.B.B.S-M.phil
Approach to A child with cervical lymphadenopathy Professor Pushpa Raj Sharma Department of Child Health Institute of Medicine.
The lymphoreticular system is involved in the defence of the body against microorganisms and foreign substances – i.e. the immune response. Consists of.
Presented by : Bhajneesh Singh Bedi
Thymus and Spleen Dr. Raid Jastania Dec By the end of this session you should know the clinical and pathological features of –Thymic hyperplasia.
Diagnostic Slide Session Case DS Miguel A. Guzman, MD 1 Zissimos Mourelatos, MD 2 1 Neuropathology Fellow 2 Director, Neuropathology Department.
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