1. Computational Neuroscience Simulation of Neural Networks for Memory

2. What is a Neuron? synapse Inputs Integration of Inputs Output

3. Action Potentials Resting Potential Action Potentials All-or-none

4. Encoding Memory Consolidation Memory Storage Recall/Recognition Memory Hippocampus

5. Patients were shown pictures of celebrities A neuron would fire an action potential for J.A. The neuron is part of a memory pattern Recognition of J.A. The "Jennifer Aniston" Neuron R. Quian Quiroga, L. Reddy, C. Koch and I. Fried (2005)

6. The "Jennifer Aniston" Neuron R. Quian Quiroga, L. Reddy, C. Koch and I. Fried (2005)

7. Alzheimer's Disease Death of neurons Beta-amyloid plaques Neurofibrillary tangles Resulting memory loss Our Model Random neuron failure Predicts effect on memory recall

8. Neuroscience and Computers

9. Hopfield Network Artificial neuron network Synaptic weights Hebb's principle

10. Computational Methods Learning/Auto Associative Memory Input (P) 111 111 110 Size 3x3 Output (W) 331 331 113 Size 3x3 W(1,1)={[P(1,1)*2]-1}+{[P(1,1)*2]-1} W(1,1)=1+1=2 Output (W) 031 301 110 Size 3x3

11. Computational Methods Recall/Synchronous + Asynchronous Update Original (P) 111 111 110 Size 3x3 Input (Y0) 1 1 0 Size 3x3 Input (W) 013 101 310 Output (Y) 11…1 11…1 01…1 Y(:,2)=W*Y(:,1)

12. Simulating Memory

13. Better RecallPoorer Recall

14. Our Study Neurons Patterns Recall Percentage Our Goal: Find Relationships Between Variables

16. Percent Recall as a Function of Patterns with a Set Number of Neurons Number of Patterns Percent Recall

17. P < NK N =.08 Percent Recall as a Function of Neurons and Patterns Number of Neurons Number of Patterns

18. Modeling Random Synaptic Failure Randomly lowering synaptic weight values to simulate random neuron failures Equate to a preliminary model for Alzheimer's Disease

23. Is our model accurate?

24. Questions?

25. Dr. Minjoon KouhDr. David Miyamoto Dr. Roger KnowlesDr. Steve Surace Aaron Loether Anna Mae Dinio-Bloch Myrna Papier Janet Quinn John and Laura Overdeck The Crimmins Family Charitable Foundation Ina Zucchi Family Trust NJGSS Alumni and Parents 1984 – 2012 AT&T Foundation Google Johnson & Johnson Wellington Management Special Thanks To...

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