1. Cell Development II Cell Signaling and Disease Models Cell Social Media BKA

2. Group Members Nishi Bryska, UNC Charlotte Sharon Bullock, UNC Charlotte Katie Crump, VCU-IRACDA Teshell Greene, VCU-IRACDA Derek Kendig, VCU-IRACDA Michelle Pass, UNC Charlotte Facilitator: Suann Yang, Presbyterian College

3. Context of the Teachable Unit General biology major’s class (cell biology section) Target class size is 60 students, with 10 working groups of 6 students each Co-requisite coursework: general chemistry A one semester course, 2 lectures at end of the semester. 5 hours class time total, 10 hours out of class time.

4. Learning Goals Students should understand 1.How a signal is transduced, relayed, and amplified to lead to a biological response. 2.The regulation and termination of a biological signal and response in normal and diseased states. 3.How cell signaling regulates homeostasis.

5. Tidbit Objectives Students should be able to: 1.Describe how a message is communicated. 2.Diagram a signaling pathway. 3.Predict how disturbing the components of the pathway will affect cell signaling response.

6. Prior Knowledge Gained Cell signaling terms – Protein-protein interactions – Receptor – Ligand and how it interacts with receptors – Signal relay and response Cell membranes are selectively permeable Extracellular signals elicit cellular responses Basics of regulation

7. Generic Signal Pathway Signal Receiver Relay/ Transducer Response Mom

8. Group Work (4 mins) Diagram a Signaling Model Using The Shapes Provided -Take shapes out of the envelope -Use shapes to model the pathway

9. Cytosol Extracellular Fluid Response

10. Group Work (4 mins) Diagram a Signaling Model Using The Shapes Provided -Take shapes out of the envelope -Use shapes to model the pathway Hint: Orange = same type of molecule

11. Cytosol Extracellular Fluid. Response

12. Real World Scenario For upcoming polls please enter the site http://www.pollev.com into your web browser or set your phone up to text message the number ‘37607’ as the phone number. http://www.pollev.com

13. Don’t forget: You can copy- paste this slide into other presentations, and move or resize the poll. Poll: Do you know someone with diabetes?

14. Diversity of People with Diabetes

15. Clinical Scenario In diabetes the response of one important pathway is to transport glucose from the extracellular fluid (ECF)/blood into the cytosol of cells. This pathway becomes disrupted as part of diabetes.

16. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin

17. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin Response

18. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin Response

19. Don’t forget: You can copy- paste this slide into other presentations, and move or resize the poll.

20. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin Response

21. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin Sugar Response

22. Don’t forget: You can copy- paste this slide into other presentations, and move or resize the poll.

23. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin Response

24. Cytosol Extracellular Fluid Sugar Insulin Receptor Insulin Sugar Response

25. Type II Diabetes The process of glucose accumulation in the extracellular fluid or blood is due to insulin resistance (inactivation of receptor) Glucose level

26. Acknowledgements HHMI SI and Dr. Kathrin Stanger-Hall Suann Yang Cell Development I (Group 1) Evolution Group (Group 4) Dean of the College of Arts & Sciences at UNC Charlotte Dr. Nichols-Casebolt at VCU and the Office of Research