1. CTMS KC Successes and Challenges Robert Annechiarico Cross KC April 2009

2. Agenda Accomplishments Next steps Challenges After this meeting, you should be able to answer: What does the CTMS KC Support? Have the Knowledge Centers increased community awareness and understanding of caBIG®? Have new tool adoptions been facilitated by the KCs? Is your KC creating a searchable knowledge base? Have the KC’s helped bridge new communities?

3. Accomplishments Summary Population and maintenance of the technology stack Wiki, forums, demo site, tracker, source code Increased awareness of the CTMS tools and work As measured by page hits over time Enhanced access to CTMS tools and resources Releases and documentation organized on the Wiki Setup and maintained demonstration site Development of an indexed, searchable knowledge base Content from forums, email exchanges Facilitation of adoption Hands-on deployment help, forum question responses Contribution to the overall cross-Knowledge Center effort Source code contribution white paper, review and validation of Wiki extensions, Standardize on Cross KC Wiki interface

4. Accomplishments Wiki Tools CCTS, caAERS, C3PR, PSC, LabViewer, C3D Connector, caXchange Projects CTMS WS Community, BAM Knowledge Base KB Articles, FAQs Resources Demonstration Sites, Announcements, Feedback, Training, Presentations, Documentation Library, Outreach Efforts

5. Accomplishments KC Users A large user base to support – NEED TO SHOW OTHER KCs Indicators suggest growing interest in CTMS Knowledge Center

6. Accomplishments Application Page Views NEED TO SHOW OTHER KCs Proportional growth of individual application inquires More sensitive measures are needed

7. Cross KC Wiki Activities

8. Accomplishments Wiki – Tool Documentation

9. Accomplishments Setup and Monitor Forums 15 forums (General, developer/end user per tool, announcements) 97 topics, 254 posts

10. Accomplishments Forums Activity

11. Accomplishments Forum Examples and Evolution Sep Oct Nov Dec Jan Feb Mar Aug About the CTMS KC Forums The CTMS Knowledge Center forums are used to post questions about anything related to the caBIG CTMS software products or the Knowledge Center… About the CTMS KC Forums The CTMS Knowledge Center forums are used to post questions about anything related to the caBIG CTMS software products or the Knowledge Center… Feedback: September 8-9 CTMS Face to Face WELCOME to a discussion using the CTMS Knowledge Center wiki on the September 8 and 9 CTMS Face to Face meeting at St. Jude Children's Research Center in Memphis, TN. Feedback: September 8-9 CTMS Face to Face WELCOME to a discussion using the CTMS Knowledge Center wiki on the September 8 and 9 CTMS Face to Face meeting at St. Jude Children's Research Center in Memphis, TN. Posting Clinical Trial Data on the Grid Greetings, I have a few questions about posting clinical trial data on the grid… Data Sharing…HIPAA…grid… Posting Clinical Trial Data on the Grid Greetings, I have a few questions about posting clinical trial data on the grid… Data Sharing…HIPAA…grid… Oracle space requirements? We would like to install stand alone caAERS for evaluation. I understand that the minimum memory requirements are 2 GB RAM and 36 GB Disk Space. How much of the disk space do folks set aside for the Oracle database? Oracle space requirements? We would like to install stand alone caAERS for evaluation. I understand that the minimum memory requirements are 2 GB RAM and 36 GB Disk Space. How much of the disk space do folks set aside for the Oracle database? Summary 3 Reports & anatomic sites …Why do C3PR and the NCI's requirements for the Summary reports differ? Are the NCI's disease sites just examples, not requirements, or is this list antiquated and likely to change shortly to be more like what is currently in C3PR?... Summary 3 Reports & anatomic sites …Why do C3PR and the NCI's requirements for the Summary reports differ? Are the NCI's disease sites just examples, not requirements, or is this list antiquated and likely to change shortly to be more like what is currently in C3PR?...

12. Accomplishments Demo Tier Public tier at Duke Private (demo) tier at SemanticBits Weekly database restore LabViewer ca Xchange

13. Accomplishments Knowledge Base C3PR caAERS PSC C3D caXchange

14. Accomplishments Tracker Bugzilla Bug tracking, issue tracking, use case tracking (not in heavy use yet) Identified gaps, usage scenarios Validated required changes locally

15. Accomplishments Source Code Repository Subversion Releases, source code, patches Not in heavy use yet Drafted code contribution white paper Background Code Contribution Mechanisms Incubators Patches Direct Contribution Considerations Project Ownership Modularity Core Contributions Recommendations

16. Accomplishments Adoption Assistance Assisted a large number of organization through email and forums Hands-on help extended by Knowledge Center to different adopters with installation and bug fixes Bill Dyer – CCTS installation incl. C3D connector and Loading Labs Ken Quinn (Roswell Park) – caAERS Rick Sanchegraw (Health. Missouri) – caAERS Farid Mohammad (Duke) - C3PR, caAERS Amish Shah (CALGB) – caAERS Bob – caAERS BAM team with their Wiki requirement

17. Accomplishments Outreach Effort Presented and scheduled to present at various meetings and conferences, to name a few AMIA – Translational Informatics Society for Clinical Trials Bio-IT World ASCO As a result we have been contacted by various groups and companies Rapid Pharmaceuticals Dental Practice based Research Network (PBRN) Organized and provide support demonstration at with different groups within caBIG and outside caBIG Walter Reed Army Medical Center Different workspaces and conferences.

18. Next Steps Summary Enhance documentation Documentation versioning, homogenize templates Train the trainer (documentation to help cancer centers) Support new tools CDMS, COPPA, CTRP, PLT, CCTS 2.0 Document processes SOPs for request handling, documentation versioning, etc. Leverage technology stack fully Bugzilla, SVN Monitor access more completely (e.g. Google Analytics) Wiki, forums, demo tier

19. Next Steps Enhance Wiki Content Documentation Convert additional documents to wiki content Version documents Homogenize templates Releases Additional releases – map releases to documentation versions

20. Next Steps SOPs Forum triage Request received, categorized, logged in tracker, assigned, etc. Wiki content editing Who can edit which parts of the wiki when? Reporting Issue reporting Site usage (forums, wiki, etc.) Use cases and prioritization Community code contribution Documentation versioning Tool release

21. Next Steps Customer Analysis Usage Google Analytics Customer Feedback Cross-KC feedback form

22. Next Steps Additional Tools Support for Documentation, training material, triaging and (maybe) fielding questions, demonstration tier, forums, etc. CDMS New Clinical Data management System procurement by NCI COPPA Enterprise services for Persons, Organizations, Protocol Abstractions, and their Correlations PLT Protocol Lifecycle Tracking CTRP Clinical Trials Reporting Program

23. Next Steps Train the Trainer Materials Documentation to help organizations set up training programs and maintain CTMS tools Documentation Deployment and Administration Guidelines Training Guide Troubleshooting Guide External Resources Guide Presentations/Demonstrations An Overview of the CTMS Applications Setting Up a Training Program Troubleshooting Technical Problems

24. CTMS KC Challenges Building a critical mass of users Organize various application versions on the Wiki Currently varies with each tools Frequency and release numbers are not consistent Fielding requests from various channels and track them centrally using a tracking system Prepare and provide training material for the trainer Include code contributions from adopters to new application releases Establish best practices for Responding to issues Working on bug fixes and patches Creating FAQ’s Updating documentation Closing issues and collecting feedback

25. Questions and Answers