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Published byOwen Shanon Carson Modified over 9 years ago
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1 Features of an NMR spectrum: SHAPE Spin Coupling: Neighboring nuclei “split” NMR signals Usually n neighbors splits the signal into n+1 peaks Multiplicity = n+1 Which Isomer of C 5 H 10 O gives rise to this spectrum? Quartet means the nuclei responsible for this signal have 3 H’s “next door” Triplet => 2 neighbors
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2 Origin of Spin Coupling: Nearby nuclei effect the magnetic field E
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3 When a neighbor adds to H 0 the E is larger, and so is the chemical shift
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4 Pascals Triangle predicts pattern
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5 Multiplets have predictable shapes Doublets: 1:1 Triplets: 1:2:1 Quartets: 1:3:3:1 Quintet: 1:4:6:4:1
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6 The extent to which neighboring nuclei effect the E changes depends on the geometry of the molecule. It does not depend on the magnet strength. Coupling is MUTUAL, so extent of splitting is equal for both signals. The distance between the individual peaks making up the doublet is called the “coupling constant” (J). Here J is 7 Hz.
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7 Coupling constants are dependant primarily on conformation/ orientation between coupled signals They are independent of magnet strength
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8 Generally coupling is only observed when neighbors are ≥ 3 bonds away from eachother
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9 Putting the features together allows for structure elucidation. The following spectrum is for C 2 H 4 Cl 2 The Area of signal a is 3 times larger than b (CH 3 ?) It is a doublet (ie it has only one neighbor) Therefore a is a methyl next to a methine: CH 3 -CH
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11 It is important to note that non-equivalent nuclei split each other. A split in one requires a split in the other. In addition, the coupling constants will be the same for each type of nuclei.
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12 Draw the structure of C 3 H 7 I consistent with this 1H NMR spectrum
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Complications in 1H NMR Hb is split into more than 5 peaks. Coupling to “non-equivalent” neighbors may modify the simple n+1 rule: Max splitting is (n+1)(m+1) where n and m are the numbers of neighbors on each side 13
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14 With 3 neighbors on left and 1 neighbor on right max multiplicity = (3+1)(1+1)= 8
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Despite this complication, the splitting may still simplify to n+1 even with non-equivalent neighbors 15 Multiplicity = 6 (predicted as (3+1)(2+1) = 12
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16 Signals from coupled protons that are close together (in Hz) can show distorted patterns. When ν >> J, the spectra is said to be first-order. Non-first-order spectra assume more complex shapes than Pascal’s triangle predicts and can only be analyzed with the help of computers. >>J >J ≈J <<J J Complications in 1H NMR: Signal distortion in non-first-order spectra
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