1. JONATHAN IMS Non-Invasive Glucometer by Grove Instraments™

2. Invasive Glucometer (Current) Present day – best way blood sugar level  The reason is accuracy Problems: 1.Can be painful 2.Messy 3.Costly 4.Average number of tests a day is 1.6, compared to the recommend 4 times a day

3. Non-Invasive Glucometer (Future) How it works: 1.Finger or Earlobe goes into the slot 2.Uses near-infrared light to measure real-time blood glucose levels 3.Takes 20 seconds or less What Separates This Device From Other Non-Invasive Devices? 1.“Optical Bridge” 2.Measurements are taken directly from the blood not from interstitial fluid

4. Non-Invasive Glucometer Data Clinical Trials  40 in-house sessions a week Data  Mean Average Relative Difference (MARD) of 8 to 12%  International Standard requires glucometers to differ from blood standard by less than 20% Blood Glucose FastingLess than or equal to 110 mg/dL 2 hrs after eating Less than 140 mg/dL (≤ 50 yrs old) Less than 150 mg/dL (50-60 yrs old) Less than 160 mg/dL ( ≥ 60 yrs old) Random (casual) 80 -120 mg/dL before meals or waking up 100-140 mg/dL at bedtime

5. Conclusion Grove’s Device  Passed International Standard for the last 2 years  Expected to be released during 2013  Faster, cleaner, and pain free compared to invasive devises  Small and battery operated Limitations  MARD percentage

6. Bibilography 1. Ferrai, M. Mottola, L. and Quaresima, V. Prinicples, Techinques, and Limitations of Near Infared Spectroscopy. Canadian Journal of Applied Physiology 29(4): 463-487, 2004. 2. Grove Instruments. About Grove Instruments.. 3. Grove Instruments. Clinical Preformance.. 4. Grove Instruments. Grove Technology.. 5. Pogoreic, Deanna. “Bloodless Glucometer Uses Light to Check Blood Sugarr in 20 Seconds or Less.” MedCity News. 6/28/2012.. 6. Thompson, G. and Dalkin, A. Blood Glucose. WebMD. 7/5/2011..