1. Kevin Latinis, M.D./Ph.D. Division of Rheumatology Dept. of Internal Medicine klatinis@kumc.edu Rheumatology 101: What you need to know for your ambulatory medicine experience

2. Rheumatology 101 Arthritis -Inflammatory (RA, spondyloarthropathies) -Mechanical (OA) LupusFibromyalgia Low back pain and other peri-articular complaints General musculoskeletal exam (time permitting)

3. Mechanical vs. Inflammatory Arthritis Latinis, K., et al The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003.

4. Osteoarthritis-Background Very common -2 nd leading cause for disability in USA -In patients 60 and older: affects 17% of men and 30% of women -Estimated that 59.4 million patients will have OA by the year 2020 Etiology -primary idiopathic -secondary

5. Osteoarthritis-Distribution Latinis, K., Dao, K, Shepherd, R, Gutierrez, E, Velazquez, C. The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003. Bouchard’s Heberden’s

7. Osteoarthritis-Diagnosis Clinical Supported by X-rays Non-inflammatory lab data, if any

8. Osteoarthritis-Treatment Pain relief -Analgesics and NSAIDs/Cox-2 Inhibitors SMOADs (structure modifying osteoarthritis drugs) -Glucosamine Sulfate -see meta-analysis McAlindon et al. JAMA, 283: 3/2000, p. 1469 -many under development Non-pharmacologic approaches -Reduce stress/load on joint -Strengthen surrounding muscles-PT/OT -Weight reduction -Patient education Limit disability and improve quality of life

9. Osteoarthritis-Treatment Joint Replacement Surgery -Primarily of knee and hip, but also available in hands, shoulders,& elbows -Indications: 1. pain at rest 2. instability -patients benefit from aggressive PT before & after surgery Other surgical procedures

10. Clinical Pearl: Arthritis of the DIP joint OA (non-inflammatory)Psoriatic Arthritis (inflammatory)

11. Inflammatory Arthritis Rheumatoid arthritis Spondyloarthropathies -Undifferentiated -Ankylosing spondylitis -Psoriatic arthritis -Reactive arthritis (formerly Reiter’s syndrome) -Enteropathic arthritis SLE, Sjogrens, Scleroderma, Polymyalgia rheumatica, Vasculitis, Infectious (bacterial, viral, other), Undifferentiated connective tissue disease

12. Latinis, K., et al The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003.

13. Rheumatoid Arthritis-Background Symmetric, inflammatory polyarthritis Affects ~1% of our population Occurs in women 3x more than men Etiology -Genetic, class II molecules (HLA-DRB1) -Autoimmune -?Environmental

14. Rheumatoid Arthritis-Distribution Latinis, K., et al The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003.

16. Definition -An inflammatory multisystem disease of unknown etiology with protean clinical and laboratory manifestations and a variable course and prognosis. -Immunologic aberrations give rise to excessive autoantibody production, some of which cause cytotoxic damage, while others participate in immune complex formation resulting in immune inflammation. Systemic Lupus Erythematosus (Lupus)-Background

17. Clinical features -Clinical manifestations may be constitutional or result from inflammation in various organ systems including skin and mucous membranes, joints, kidney, brain, serous membranes, lung, heart and occasionally gastrointestinal tract. -Organ systems may be involved singly or in any combination. -Involvement of vital organs, particularly the kidneys and central nervous system, accounts for significant morbidity and mortality. -Morbidity and mortality result from tissue damage due to the disease process or its therapy. Systemic Lupus Erythematosus (Lupus)-Background

18. Systemic lupus erythematosus classification criteria (SOAP BRAIN MD) S 1. Serositis: (a) pleuritis, or (b) pericarditis O 2. Oral ulcers A 3. Arthritis P 4. Photosensitivity M 10. Malar rash D 11. Discoid rash B 5. Blood/Hematologic disorder: (a) hemolytic anemia or (b) leukopenia of < 4.0 x 10 9 (c) lymphopenia of < 1.5 x 10 9 (d) thrombocytopenia < 100 X 10 9 R 6. Renal disorder: (a) proteinuria > 0.5 gm/24 h or 3+ dipstick or (b) cellular casts A 7. Antinuclear antibody (positive ANA) I 8. Immunologic disorders: (a) raised anti-native DNA antibody binding or (b) anti-Sm antibody or (c) positive anti-phospholipid antibody work-up N 9. Neurological disorder: (a) seizures or (b) psychosis "...A person shall be said to have SLE if four or more of the 11 criteria are present, serially or simultaneously, during any interval of observation."

19. 53 yo BF with severe generalized weakness, weight loss, and chronic psychosis Alopecia Malar rash Arthritis Psychosis

20. Laboratory Data 139 4.3 106 21 16 1.4 101 7.7 22.3 3.9 Absolute lymph=0.5 298 MCV=83 ESR=119 CH50=67 (118-226) C3=31 (83-185) C4=18 (12-54) ANA + 1:5280 Anti DNA + Direct & Indirect Coombs + Anti-IgG + 24 hour urine Protein=514

22. Treatment of SLE Arthritis, arthralgias, myalgias: NSAIDS, anti-malarials (eg. Plaquenil), Steroids- injections, oral methotrexate Photosensitivity, dermatitis avoid Sun exposure topical steroids Plaquenil Weight loss and fatigue steroids Abortion, fetal loss ASA immunosuppression Thrombosis anti-coagulants Glomerulonephritis steroids pulse cytotoxics mycophenylate mofetil CNS disease anti-coagulants for thrombosis steroids and cytotoxics for vasculitis Infarction (secondary to vasculitis) steroids cytotoxics prostacyclin Cytopenias steroids IVIG-short term for thrombocytopenia danazol cytotoxics-if bone marrow status is known

23. Steroids in Lupus Steroid responsive Dermatitis (local) PolyarthritisSerositisVasculitisHematological Glomerulonephritis (most) Myelopathies Steroid non-responsive Thrombosis Chronic renal damage Hypertension Steroid-induced psychosis Infection

24. Latinis, K., et al The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003. ANA-When to order and how to follow up on a positive test

25. Latinis, K., et al The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003.

26. Fibromyalgia-Background Chronic musculoskeletal pain syndrome of unknown etiology Characterized by diffuse pain, tender points, fatigue, and sleep disturbances Prevalence is 2-5% with a female to male predominance of 8:1 Mean age is 30-60

27. Fibromyalgia-Diagnosis

28. 1 2 3 4 5 6 7 8 9

30. Fibromyalgia-Treatment

31. Low back pain and other peri-articular complaints- background Very common, one of the most frequent reasons to visit primary care physicians Articular vs peri-articular problems -Articular pain is generally deep or diffuse and worsens with active and passive motion -Periarticular pain usually exibits point tenderness and increased tenderness with active, but NOT passive motion

32. Latinis, K., et al The Washington Manual Rheumatology Subspecialty Consult., LWW, 2003.

35. Muscles of the rotator cuff: Supraspinatus Infraspinatus Subscapularis Teres Minor

37. Low back pain and other peri-articular complaints- Treatment RICE -Rest -Ice -Compression -Elevation NSAIDs and analgesics TimeOther

38. General Musculoskeletal Exam Underutilized by primary care providers Should be simple and quick Goal is to recognize signs of rheumatological diseases and determine if it is appropriate to refer to a rheumatologist or manage independently

40. Summary Arthritis -Inflammatory (RA, spondyloarthropathies) -Mechanical (OA) LupusFibromyalgia Low back pain and other peri-articular complaints General musculoskeletal exam (time permitting)