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Male genital pathology

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Presentation on theme: "Male genital pathology"— Presentation transcript:

1 Male genital pathology
Pathology pictures

2 62 year old male SCC of the penis, spreading through the vessels of the corpora cavernosa

3 Malignant penile carcinoma

4 59 year old male with haemochromatosis and cirrhosis
Testicular atrophy

5 Atrophic testis Low power: tunica albuginea (long arrow); seminiferous tubules (short arrow) High power: Leydig cells (long arrow); atrophic tubules (short arrows); thickened basement membrane; lack of spermatogenesis Low power High power

6 A: normal testis B: testicular atrophy  tubules have Sertoli cells but no spermatogenesis; thickened basement membrane; apparent increase in interstitial Leydig cells

7 30 year old man with dystrophia myotonica
Advanced testicular atrophy

8 Epididymitis and orchitis

9 71 year old male with prostatic hyperplasia
Chronic granulomatous epididymo-orchitis Blue arrows: cream nodules comprising lipid-laden macrophages Black arrows: hydrocoele

10 Tuberculous epididymo-orchitis
Predominantly affecting the epididymis (arrows)

11 Tertiary syphilis Gumma (arrows) of the testis Multiple irregular areas of necrosis surrounded by a zone of dense fibrosis No recognisable testicular tissue remains

12 Haemorrhagic infarction of testis due to torsion of spermatic cord

13 Testis which has recently undergone infarction
Low power: tunica albuginea (long arrow); infarcted tubule (small arrow) High power: necrotic seminiferous tubules (long arrows); oedema separating tubules (short arrows)

14 Haemorrhagic necrosis of the testis and epididymis due to torsion of the spermatic cord

15 Testicular torsion

16 Torsion of the testicular appendix

17 Bilateral cysts of epididymis

18 40 year old male Seminoma of the testis Homogeneous cream colour Testicular tumours are usually a mixture of seminoma and teratoma components

19 Seminoma of the testis Fairly well circumscribed, pale, fleshy, homogeneous mass

20 Embryonal carcinoma Haemorrhagic mass

21 Choriocarcinoma Small size; marked haemorrhage and necrosis

22 17 year old male Malignant teratoma of the testis Varied macroscopic appearance from one area to another

23 High power view of seminoma component: tumour cells (arrows) have large central nuclei and clear cytoplasm; fibrous connective tissue septae infiltrated with chronic inflammatory cells (arrowheads) Immature testicular teratoma Low power: tunica (A); residual seminiferous tubules (B); varied picture within and between fields High power: immature mesenchyme (A); immature cartilage (B); seminoma (C)  seminoma can form a component of a mixed germ cell tumour

24 Man aged 35 with ‘cannon ball’ secondaries in the lungs and a positive pregnancy test
Immature teratoma of the testis with a choriocarcinoma component Haemorrhagic necrosis of choriocarcinoma component (characteristic  due to tumour cells invading blood vessels) Homogenous white areas: seminoma

25 Teratoma of the testis Variegated cut surface with cysts

26 Mature teratoma

27 Immature teratoma

28 72 year old male Hydrocoele (blue arrows) with atrophic testis (red arrows)

29 6 year old male Hydrocoele of the spermatic cord

30 Chronic haematocoele (blue arrows) with testicular atrophy (red arrows)

31 Man aged 58 Varicocoele (blue arrows) Appendix of epididymis (red arrows) Hydatid of Morgagni (black arrow) with twisted pedicle

32 72 year old male with DM complicating haemochromatosis
Prostatic abscess Blue arrows: pyogenic membrane (abscess contents removed)

33 83 year old male Nodular hyperplasia of the prostate and muscle hypertrophy and trabeculation of the bladder

34 Low power High power Low power: increased stroma and proliferated glands (arrows) High power: double layer of nuclei (long arrows); regular nuclei and inconspicuous nucleoli (arrowheads) Medium power

35 Prostatic hyperplasia
Hypertrophy of bladder muscle Cystitis Bilateral hydroureter and hydronephrosis Suppurative pyelonephritis

36 BPH Well-define nodules compress the urethra into a slit-like lumen Histology: nodules of hyperplastic glands on both sides of the urethra


38 Carcinoma in the posterior prostate

39 Adenocarcinoma of the prostate
Low power: proliferation of closely-packed small glands; infiltrating into surrounding stroma High power: glands are closely applied (long arrows); enlarged, hyperchromatic nuclei; nuclei are irregularly arranged in the cells (arrowheads) Low power High power

40 Poorly differentiated prostatic adenocarcinoma
Almost complete loss of the glandular architecture, pleomorphic nulei, prominent nucleoli

41 Advanced carcinoma of the prostate

42 Adenocarcinoma of the prostate
Lower left is posterior aspect (where carcinomatous tissue is) Solid white tissue of cancer  unlike spongy appearance of benign peripheral zone

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