1. ECM degradation Artery ligation Necrotic tissue Fibroblasts Neutrophils Macrophages Pro-inflammatory cytokines Collagen C-terminus collagen peptides Pro-fibrotic factors ECM synthesis MMP-9 Aim 3 Aim 1 Myocardial infarction Figure 1. Diagram depicting overall experimental design to evaluate the influence of MMP-9 generated collagen peptides on LV remodeling post-MI.

2. MMP-9 M YOCARDIAL I NFARCTION C-terminus collagen peptides InflammationFibrosis A DVERSE R EMODELING Aim 2 + Exogenous C-terminus collagen peptides Aim 1 Aim 3 +

3. MMP-9 M YOCARDIAL I NFARCTION C-terminus collagen peptides InflammationFibrosis A DVERSE R EMODELING Aim 1 + Exogenous C-terminus collagen peptides Aim 2 Aim 3 Macrophage Fibroblast

4. Artery ligation Necrotic tissue Fibroblasts Neutrophils Macrophages Pro-inflammatory cytokines Collagen C-terminus collagen peptides Pro-fibrotic factors ECM synthesis MMP-9 Aim 1 Myocardial infarction Aim 3 Figure 1. Diagram depicting overall experimental design to evaluate the influence of MMP-9 generated collagen peptides on LV remodeling post-MI. ECM degradation Aim 2 Signaling pathway?

5. Artery ligation Necrotic tissue Fibroblasts Neutrophils Macrophages Pro-inflammatory cytokines Collagen C-terminus collagen peptides Pro-fibrotic factors ECM synthesis MMP-9 Aim 1 Myocardial infarction Figure 1. Diagram depicting overall experimental design to evaluate the influence of MMP-9 generated collagen peptides on LV remodeling post-MI. ECM degradation Aim 2 Signaling pathway? Aim 3