An important transcription elongation facilitator is FACT (facilitates chromatin transcription) – 2 subunits: Spt16 binds to H2A-H2B dimers acid-rich C-terminus is essential for these nucleosome remodeling activities SSRP1 binds to H3-H4 tetramers – Facilitates transcription through nucleosome by promoting loss of at least one H2A-H2B dimer Acts as histone chaperone promoting re-addition of H2A-H2B dimer to nucleosome that has lost dimer FACT (facilitates chromatin transcription) MCM Mini Chromosome Maintenance complex, or Minichromosome Maintenance protein complex or mini-chromosome maintenance (MCM) 2-7 helicase complex has a role in both the initiation and the elongation phases of eukaryotic DNA replication, specifically the formation and elongation of the replication fork. MCM is a component of the pre-replication complex, which is a component of the licensing factor. MCM consists of six related polypeptides that form a ring structure.DNA replication replication forkpre-replication complexlicensing factor
Replication fork: When replicating, the original DNA splits in two, forming two "prongs" which resemble a fork,
Comparative Proteomic Analysis Software Suite (CompPASS) which employs an unbiased methodology for the identification of high-confidence candidate interacting proteins (HCIPs) from parallel non-reciprocal proteomic data and facilitates functional dissection of interaction networks.