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Extensions of Mendelian Analysis Modifications of Mendelian Ratios Single Gene modifications Two gene pair modifications: modified 9:3:3:1 ratios Modification.

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Presentation on theme: "Extensions of Mendelian Analysis Modifications of Mendelian Ratios Single Gene modifications Two gene pair modifications: modified 9:3:3:1 ratios Modification."— Presentation transcript:

1 Extensions of Mendelian Analysis Modifications of Mendelian Ratios Single Gene modifications Two gene pair modifications: modified 9:3:3:1 ratios Modification of Expression

2 Single Gene modifications Incomplete dominance (partial dominance) Multiple alleles Lethal alleles

3 Incomplete dominance (partial dominance) Expression of a heterozygous phenotype that is distinct from and usually intermediate to either homozygous phenotype

4 Incomplete dominance (partial dominance) Tay Sachs and Sickle Cell Anemia Heterozygous are intermediate at the biochemical level.

5 Multiple Alleles &Co-Dominance

6 Bombay phenotype H allele affected Recessive epistasis Show O phenotype Genotype variable

7 Lethal alleles Yellow dominant to Agouti coat color No purebred yellow Deletion mutation Recessive for lethality

8 Two gene pair modifications: modified 9:3:3:1 ratios Epistasis Suppression Complementary gene action

9 Recessive Epistasis

10 Dominant Epistasis

11 Suppression

12 Complementary gene action

13

14 Modification of Expression Pleiotropic effects Penetrance and Expressivity

15 Pleiotropic effects

16 Penetrance No expression

17 Expressivity


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