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Copyright © 2009 Pearson Education, Inc. Extensions of Mendelian Genetics Chapter 4 Lecture Concepts of Genetics Tenth Edition.

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Presentation on theme: "Copyright © 2009 Pearson Education, Inc. Extensions of Mendelian Genetics Chapter 4 Lecture Concepts of Genetics Tenth Edition."— Presentation transcript:

1 Copyright © 2009 Pearson Education, Inc. Extensions of Mendelian Genetics Chapter 4 Lecture Concepts of Genetics Tenth Edition

2 Copyright © 2009 Pearson Education, Inc. 4.1Alleles Alter Phenotypes in Different Ways Wild type Loss of function Null Gain of function New alleles are produced by mutation

3 Copyright © 2009 Pearson Education, Inc. 4.2Geneticists Use a Variety of Symbols for Alleles

4 Copyright © 2009 Pearson Education, Inc. 4.3Neither Allele Is Dominant In Incomplete, or Partial, Dominance

5 Copyright © 2009 Pearson Education, Inc. Figure 4.1

6 Copyright © 2009 Pearson Education, Inc. 4.4In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident (There’s no “blending” of phenotypes)

7 Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.1The ABO Blood Groups 4.5.2The A and B Antigens

8 Copyright © 2009 Pearson Education, Inc.

9 Figure 4.2

10 Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.3The Bombay Phenotype

11 Copyright © 2009 Pearson Education, Inc. Figure 4.3

12 Copyright © 2009 Pearson Education, Inc. 4.5Multiple Alleles of a Gene May Exist in a Population 4.5.4The white Locus in Drosophila More than 100 alleles

13 Copyright © 2009 Pearson Education, Inc. 4.1

14 Copyright © 2009 Pearson Education, Inc. 4.6Lethal Alleles Represent Essential Genes 4.6.1Recessive Lethal Mutations

15 Copyright © 2009 Pearson Education, Inc. Figure 4-4 Copyright © 2006 Pearson Prentice Hall, Inc. ?

16 Copyright © 2009 Pearson Education, Inc. 4.6Lethal Alleles Represent Essential Genes 4.6.2Dominant Lethal Mutations

17 Copyright © 2009 Pearson Education, Inc. 4.7Combinations of Two Gene Pairs With Two Modes of Inheritance Modify the 9:3:3:1 Ratio

18 Copyright © 2009 Pearson Education, Inc. Figure 4.5

19 Copyright © 2009 Pearson Education, Inc.

20

21 4.8Phenotypes Are Often Affected by More Than One Gene 4.8.1Epistasis

22 Copyright © 2009 Pearson Education, Inc. Figure 4.6

23 Copyright © 2009 Pearson Education, Inc.

24

25 Figure 4.7

26 Copyright © 2009 Pearson Education, Inc. Figure 4.8

27 Copyright © 2009 Pearson Education, Inc. Figure 4.9

28 Copyright © 2009 Pearson Education, Inc. 4.9Complementation Analysis Can Determine if Two Mutations Causing a Similar Phenotype are Alleles

29 Copyright © 2009 Pearson Education, Inc. Figure 4.11

30 Copyright © 2009 Pearson Education, Inc. 4.10Expression of a Single Gene May Have Multiple Effects Pleiotropy

31 Copyright © 2009 Pearson Education, Inc. 4.11X-Linkage Describes Genes on the X Chromosome X-Linkage in Drosophila

32 Copyright © 2009 Pearson Education, Inc. Figure 4.12

33 Copyright © 2009 Pearson Education, Inc. Figure 4.13

34 Copyright © 2009 Pearson Education, Inc. 4.11X-Linkage Describes Genes on the X Chromosome X-Linkage in Humans

35 Copyright © 2009 Pearson Education, Inc. Table 4.3

36 Copyright © 2009 Pearson Education, Inc. Figure 4.14

37 Copyright © 2009 Pearson Education, Inc. 4.12In Sex-Limited and Sex-Influenced Inheritance, an Individual’s Sex Influences the Phenotype

38 Copyright © 2009 Pearson Education, Inc. Figure 4.15

39 Copyright © 2009 Pearson Education, Inc. Figure 4.16

40 Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Penetrance and Expressivity

41 Copyright © 2009 Pearson Education, Inc. Figure 4.17

42 Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Genetic Background: Suppression and Position Effects

43 Copyright © 2009 Pearson Education, Inc. Figure 4.18

44 Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Temperature Effects—An Introduction to Conditional Mutations

45 Copyright © 2009 Pearson Education, Inc. Figure 4.19

46 Copyright © 2009 Pearson Education, Inc. 4.13Genetic Background and the Environment May Alter Phenotypic Expression Nutritional Effects Onset of Genetic Expression Genetic Anticipation Genomic (Parental) Imprinting

47 Copyright © 2009 Pearson Education, Inc.


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