Presentation is loading. Please wait.

Presentation is loading. Please wait.

Bioorganic Chemistry Amines Chapte 16. Amines  Amine Nomenclature –Amines are derivatives of Ammonia, NH 3 –Classified as 1 o, 2 o, and 3 o amines (Count.

Similar presentations


Presentation on theme: "Bioorganic Chemistry Amines Chapte 16. Amines  Amine Nomenclature –Amines are derivatives of Ammonia, NH 3 –Classified as 1 o, 2 o, and 3 o amines (Count."— Presentation transcript:

1 Bioorganic Chemistry Amines Chapte 16

2 Amines  Amine Nomenclature –Amines are derivatives of Ammonia, NH 3 –Classified as 1 o, 2 o, and 3 o amines (Count R groups on Nitrogen.)

3 IUPAC Nomenclature Amines are named by naming the “R” groups And adding “amine” as a suffix

4 Nomenclature  Aromatic amines –Aniline is parent –Substitution on N is named as a “N-alkyl” or “N,N-dialkyl” aniline 3

5 Nomenclature  Nomenclature –Use a “N” to locate alkyl groups –More complicated amines are use “amino” to name the N group as a substituent 2

6 Nomenclature  Heterocyclic Amines * *

7 A Little Organic Fun  znkY znkY  GJkLJA GJkLJA

8 Physical Properties  Amine Physical Properties –Boiling points slightly lower than alcohols –Hydrogen bonding »occurs with 1 o and 2 o amines »not possible with 3 o amines –Water solubility is similar to same MW alcohols

9 Physical Properties  Amine Physical Properties –Strong odors »simple amine have an odor similar to ammonia »resemble the odor of raw fish »some diamines have especially bad odors

10 Reaction of Amines  Amines are BASES! –React with acids and accept a proton (H + ) to Form alkyl ammonium salts

11 Reaction of Amines  Amines are BASES! ?

12 Reaction of Amines  Amines are BASES!

13 Nomenclature  Nomenclature

14 Quaternary Ammonium Salts  Four alkyl groups on N –only with ammonium salts –NOT made by acidifying an amine

15 So……. Tell me about some Way Cool far out Amines………….. From Yahoo Images

16 Alkaloids  Nitrogen containing compounds found in roots, bark, leaves, berries, or fruit.  Thousands have been extracted (in containers or by chewing) and used to produce physiological effects in humans and animals  Some are deadly poisons, some cure diseases and some are addictive drugs

17 Alkaloid Example  Coniine –Simple alkaloid –Very poisonous –Hemlock plant »Socrates ( BC) Hemlock From Yahoo Images Socrates ( BC) was found guilty of corrupting the minds of the youth of Athens and sentenced to death by drinking a mixture containing poison hemlock.

18 Alkaloid Example  Nicotine –Found in smoking, chewing –Stimulant in small doses –Habit forming –Tars, CO, carcinogens present in smoke From Yahoo Images How do you know how much Nicotine is in a smoke?

19 Alkaloid Example  Caffeine –Stimulating action –Found in: »coffee »tea (black, green) »colas »No-Doz »chocolate (theobromine) From Yahoo Images

20 Alkaloid Example  Atropine –Plants: »henbane »Belladonna- (deadly nightshade) –Dilate pupils of eyes »“used by Cleopatra and Roman Women to Enlarge the pupils to Look more attractive From Yahoo Images

21 Alkaloid Example  Morphine –Found in Opium Poppy –Simular compounds include Codeine, Heroin, Demerol, Methadone –Valuable pain killer –Troubled drug for abuse From Yahoo Images

22 Other Alkaloid Example  Quinine –Cinchona bark –Used to treat Malaria  Strychnine –Nux Vomica –rat poison  Reserpine –Indian Snake Root –lowers bp Indian Snake Root from Yahoo Images

23 Amphetamines  Amphetamines –Synthetic amines –Powerful stimulants CNS »reduce fatigue »raise glucose blood level »control mild depression »reduce hyperactivity in children »appetite depressant


Download ppt "Bioorganic Chemistry Amines Chapte 16. Amines  Amine Nomenclature –Amines are derivatives of Ammonia, NH 3 –Classified as 1 o, 2 o, and 3 o amines (Count."

Similar presentations


Ads by Google