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Syft Technologies Unsurpassed Productivity. Overview Real-Time Flavor Analysis using SIFT-MS Customer Case Studies Syft Food and Flavor Solutions Extra:

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Presentation on theme: "Syft Technologies Unsurpassed Productivity. Overview Real-Time Flavor Analysis using SIFT-MS Customer Case Studies Syft Food and Flavor Solutions Extra:"— Presentation transcript:

1 Syft Technologies Unsurpassed Productivity

2 Overview Real-Time Flavor Analysis using SIFT-MS Customer Case Studies Syft Food and Flavor Solutions Extra: Technical Overview of SIFT-MS

3 Real-time Flavor Analysis using Selected Ion Flow Tube Mass Spectrometry

4 SIFT-MS technology is a rapid, inexpensive way to analyze aroma compounds in air at ultra-trace concentrations Real-time sample analysis with high selectivity Sensitive: sub-picogram per milliliter of air Simple, nondestructive sample analysis All compounds analyzed in one scan Robust to water vapor Easy to use, with self-checking and validation Very low operating costs Remote operation, support and troubleshooting Easily integrated with existing infrastructure

5 SIFT-MS can measure and quantify most volatile compounds alkanes, alkenes, aromatics, terpenes alcohols, aldehydes, ketones, esters, furans amines, amides, pyrazines mercaptans, thioethers halogenated compounds ammonia, chlorine, hydrogen sulfide, phosphine, selected inorganic acids Examples include:

6 Static and dynamic headspace analysis SIFT-MS provides rapid, high sensitivity* static or dynamic headspace analysis of aroma compounds without preconcentration and discrimination. Simple, non-destructive sample analysis. Analyze all polarities without discrimination – no chromatographic column or SPME fibers. No artifacts (e.g. selective uptake, chemical reactions, matrix damage) from solvent extraction, preconcentration, etc. The result: rapid chemical analysis that better correlates with human aroma perception. Industry applications include: Product development. Screening and troubleshooting raw material quality issues. * For most compounds, routine detection limits are better than 1 picogram per milliliter of headspace.

7 Real-time analysis of dynamic processes SIFT-MS allows real-time monitoring of various flavor-modifying processes, such as: Enzymatic changes (e.g. tomatoes, onions) Roasting and other cooking processes (e.g. coffee, cocoa) Mixing and grinding (e.g. conching of chocolate) Real-time analysis provides unparalleled insights into the processes by which flavors develop. Through it, optimal aroma development can be achieved and formation of aroma defects prevented. Industry applications include Product development Process optimization Process-line monitoring Acetic acid Methanol Hexanoic acid

8 Real-time analysis: in vivo flavor release Real-time analysis, coupled with high sensitivity and robustness to water vapor, enables flavor release to monitored in vivo. Retronasal and mouth sampling are readily accommodated. Flavor release is a very important consideration in overall sensory perception and hence for new product development.

9 Objective measurement of flavor attributes Sensory testing sets the benchmark for product acceptability and flavor is an important component of acceptance. Sensory testing is, however, expensive, subject to fatigue and is very difficult to conduct on the process line. An exciting area of research applies SIFT-MS as a real-time, objective flavor analysis tool in both on-line and off-line scenarios. Pioneering work on Parmesan cheese utilized odor-active compounds determined by traditional methods to reliably discriminate between genuine Italian (red data in graph at top left) and imitation New Zealand (brown) Parmesan cheeses. The SIFT-MS technique shows great potential as an objective, real-time aroma grading tool for the food industry.

10 Customer Case Studies

11 Ohio State University, USA: Professor Sheryl Barringer Examples of research undertaken: Cocoa and chocolate volatiles Tomato volatiles from chewing and enzyme activity Mitigation of garlic malodor in breath Edible nuts – almonds, cashews Analytical equipment: Syft Voice100 SIFT-MS equipped with high-performance inlet Syft LabSyft software package Since 2008, 11 students have used this solution, yielding: 17 papers have been published Three papers are in preparation Many results of industry significance Total headspace concentrations above Don Homero cocoa beans roasted at 150 ˚C

12 Ohio State University, USA: Professor Jim Harper Examples of studies undertaken: Swiss cheese: sulfur compounds, chemical origins of flavor Vanilla: extract origin and interactions with ice cream ingredients ‘Warmed over flavor’ in meat Analytical equipment: Syft Voice100 SIFT-MS equipped with high-performance inlet Syft LabSyft software package Since 2008, four staff/fellows and 10 students have used this solution, yielding: Four published papers Seven papers submitted/in preparation Many results of industry significance Sulfur compounds in Swiss cheese aged 7 to 420 days

13 Multinational food company, USA: R&D laboratory Applications to date: Product development Process optimization Screening and troubleshooting raw material quality issues Analytical equipment: Syft Voice200 SIFT-MS equipped with high-performance inlet Syft autosampler interface (‘trigger scanner’ device) Syft LabSyft software package Entech Instruments 7500D headspace autosampler User since 2009

14 KaHo Laboratory of Enzyme, Fermentation and Brewing Technology, Belgium: Beer testing laboratory Applications to date: Headspace analysis of malts, including differentiation of malted barley cultivars Real-time profiling of volatiles in drink, food and feed Analytical equipment: Syft Voice200 SIFT-MS equipped with high performance inlet Syft LabSyft software package Markes Micro-Chamber thermal extractor User since 2009

15 The Syft Flavor Analysis Solution

16 The high-performance inlet provides optimum performance Syft’s Heated Inlet Extension provides optimum performance for food and flavor applications, which require rapid response times and high sensitivity. The inlet can be heated to 200 °C and is passivated with Silcosteel® coating. The inlet connects directly to the flow tube without passing through any valves, so there is no possibility of contamination from, or analyte loss on valve seats. The high-performance inlet terminates in a lure fitting that is compatible with standard hypodermic needles. Swagelok® options are also available.

17 Integration with standard autosamplers provides high throughput The Voice200® can be interfaced to standard autosamplers including: Entech large-volume robotic autosamplers Markes Unity thermal desorbers CTC Combipal autosamplers Markes Micro-Chamber thermal extraction devices The Voice200® uses standard synchronization protocols to communicate with third-party devices.

18 The LabSyft suite provides sophisticated data analysis The LabSyft software suite contains a range of data viewing and analysis tools including: Live Viewer: View scan data in real time. Data Viewer: Multi-scan viewing and data analysis and extraction. Method Editor: Develop and modify scan methods. Reprocess old scan data with new analysis rules. Library: View and add compound data to the Syft Compound Library. Batch Scanner: Create batches of scans. View scan results. Trigger Scanner: Interface with third party equipment.

19 Higher productivity and lower total cost of ownership A Syft Voice200 will analyse as many samples in three hours as a GC-MS will analyse in a 40-hr week. Higher productivity is due to: Greatly reduced calibration requirements. Minimal system maintenance and cleaning requirements – no columns and ultra-clean chemical ionization. Remote product support and fault diagnosis Labour costs are reduced because: Operable by non-technical personnel. No or minimal sample preparation required. No pre-concentration necessary.

20 Summary Syft Technologies’ Voice200® provides unique opportunities to flavor researchers and industry. These include: Greatly increased sample throughput for headspace analysis; Analysis of a wide range of compounds without discrimination; Ability to probe enzymatic, roasting and other processes in real-time; Characterization of in vivo aroma release; Objective, real-time aroma quality analysis via odor-active compounds. Syft’s Voice200 is user friendly and easily integrated into the lab and production line.

21 Further information: Technical overview of SIFT-MS

22 A key advantage of SIFT-MS is soft ionization using three reagent ions

23 SIFT-MS uses much softer ionization agents than GC-MS. In SIFT-MS, the chemical ionization (CI) agents are called “reagent ions” or “precursor ions”. Softer ionization results in significantly less fragmentation than electron impact (EI) ionization and CI, making chromatography unnecessary and real-time analysis possible. SIFT-MS is a unique CI-MS technique because it is very soft and precisely controls ion energies. This allows repeatable, real-time quantitative analysis. SIFT-MS CI Compared with GC-MS CI and EI Ionization Electron impact ionization (70 eV) Chemical ionization: O 2 + reagent (12.1 eV) CH 2 + C2H5C2H5 + Fragment ion m/z = 91 Parent ion m/z = 106 Reagent IonRelevant Ionization Property H3O+H3O+ Proton affinity = 691 kJ mol -1 NO + Ionization potential = 9.25 eV O2+O2+ Ionization potential = 12.1 eV

24 Three reagent ions with multiple ionization mechanisms greatly enhances selectivity H3O+H3O+ NO + O2+O2+ Example: Acetone and Propanal Reagent Ion Ionization mechanism(s) (analyte-dependent) H3O+H3O+ Proton transfer H 3 O + + A  A.H + + H 2 O O2+O2+ Charge transfer (CT) O A  A + + O 2 Dissociative CT O A  Fragment + + … NO + Association NO + + A + M  A.NO + + M Hydride abstraction NO + + A  [A-H] + + HNO Also CT and dissociative CT, but less so than O 2 + (lower IP)

25 An example – a multiple compound mixture Part 1: EI mass spectrometry with GC

26 An example – a multiple compound mixture Part 2: Real-time EI mass spectrometry (without GC)

27 An example – a multiple compound mixture Part 3: Real-time SIFT-MS H3O+H3O+ NO + O2+O2+ This subset of the US EPA Compendium Method TO-15 sees all 15 compounds resolved and quantified in real time using SIFT-MS. Note that each SIFT-MS reagent ion has a different “fingerprint” for the individual compounds and for the mixture as a whole. Compound “fingerprints” (i.e. chemical ionization reaction data) are recorded in the Syft compound library software. The library records are utilized by powerful Method Editor software for straightforward development of analytical methods.

28 SIFT-MS has broad sensitivity to chemically diverse compounds The chemical ionization process employed in SIFT-MS is sensitive to a broad range of chemical species. In particular the following compounds that are problematic for standard GC-MS analysis: Reduced sulfur compounds, including H 2 S Ammonia and amines Formaldehyde and other small aldehydes Phosphine and other highly reactive compounds Thermally unstable compounds Highly polar compounds H 2 CO H2SH2S C 4 H 10 NH 3 PH 3

29 High sensitivity and wide linear range SIFT-MS offers: Part-per-trillion by volume detection limits Five or more orders of magnitude linear range High real-time selectivity


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