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WOUND DRESSING  Suitable Mechanical properties  No cell adherence  Antibacterial properties (nanosilver ) Hydrogels comprise crosslinked polymeric matrices.

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Presentation on theme: "WOUND DRESSING  Suitable Mechanical properties  No cell adherence  Antibacterial properties (nanosilver ) Hydrogels comprise crosslinked polymeric matrices."— Presentation transcript:

1 WOUND DRESSING  Suitable Mechanical properties  No cell adherence  Antibacterial properties (nanosilver ) Hydrogels comprise crosslinked polymeric matrices of renowned applications in distinct biotechnological areas, which may be synthesized by several techniques. In general and although very effective, many techniques required the need of monomers or solvents which require careful washing processes in order to be removed from the systems. On this aspect the synthesis of hydrogels developed by exposition to ionizing radiation offers advantages over the conventional methods, such as no need of monomers or toxic solvents, being also capable of sterilizing the product inside final packaging. In this work we report the loading and release of silver nanoparticles into radiation synthesized hydrogels to be applied as dressing for wound healing, from development stages to initial clinical evaluation in (Ethics Committee Reg TO 161/2013) patients with venous ulcers. PVP Hydrogels containing Nanosilver for the treatment of venous ulcers Research Approach Swelling Properties & Nanosilver Release References PVP Hydrogel & Nanosilver Gustavo H. C. Varca 1, Maria J.A. de Oliveira 1, Jorge G.S. Batista 1,, Vinicius S. Carvalho 1, Gabriela A. Dos Santos 1, Talita R. Cardoso 2, Albeliggia B. Vicentine 2,Ademar B. Lugão 1 varca@usp.br 1 Instituto de Pesquisas Energéticas e Nucleares – IPEN-CNEN/SP, SP, Brazil; 2 Instituto Tocantinense Presidente Antônio Carlos – ITPAC Porto Nacional, TO, Brazil. Figure 2. Hydrogel handling & usage. Figure 3. Mechanical Properties of the hydrogels. Figure 1. PVP based Hydrogels containing nanosilver obtained by simultaneous crosslinking and sterilization induced by gamma radiation. Conclusions The membrane produced presented suitable mechanical properties to be applied as wound dressings. The Patient ulcer treated with the dressings presented increased healing process and better aspects which were identified on the 5 th day. On the 10th day, the lesions were significantly smaller, with reduced odor and no report of pain. Thus the initial trials indicated that such dressing may be effectively applied for the treatment of venous ulcers, being capable of significantly reducing pain, odor and exudate formation. Clinical trial – The case of Venous Ulcers Figure 7. Patient Venous ulcer during treatment (5 th day). Figure 8. Venous ulcer during treatment (10 th day). Figure 6. Patient Venous ulcer on the 1 st day of treatment with the dressing. Mechanical Properties Figure 5. Nanosilver Release Profile - ICP-MS. Figure 4. Swelling properties of the hydrogel - (a) lyophilized form (b) regular form. Hydrogel Synthesis Acknowledgments PVP hydrogel PVP hydrogel containing nanosilver *Commercially available nanosilver solution (22 ppm) from KHEMIA® Simultaneous Polymer crosslinking & sterilization Gamma Irradiation dose (25 kGy) -8% PVP -1% PEG -1.5% Agar -22ppm Nanosilver* Hydrogel Formulation Polymer crosslinking & Sterilization Exudate absorption Reduced odor Dressings removal (every 24h) No pain No bleeding Reduced venous ulcer size Increase in revitalized tissue 10 th day 5 th day Significantly reduced odor; Reduced exudate formation; Dressings removal (every 12h) Reduced Sensitivity and pain 1st day Patient with 8.706 cm 2 venous ulcer (7 years) Dead tissue; Dressings removal (every 6h) Intense pain and odor bleeding Nanosilver release up to 48 hours Oliveira, M.J.A.; Amato, V.S. ; Lugão, A.B. ; Parra, D.F. Radiat. Phys. chem. v. 81, p. 1471-1474, 2012. Ferraz, C.C; Varca, G.H.C.; Lopes, P.S.; Mathor, M.B.; Lugao. Radiat. Phys. chem. v. 94, p. 186-189, 2014. Gel Fraction Band gel PVP ± 69 % PVP / Ag + ± 75%


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