Presentation on theme: "Amana N. Nasir, Carolyn M. Wilhelm, Joel A. Levien, John N. Udall, Jr."— Presentation transcript:
1 Amana N. Nasir, Carolyn M. Wilhelm, Joel A. Levien, John N. Udall, Jr. Massive Gastrointestinal Bleeding from a Dieulafoy Lesion in a Seven Year Old BoyAmana N. Nasir, Carolyn M. Wilhelm,Joel A. Levien,John N. Udall, Jr.
2 History of Present Illness A 7yo boy was transferred to WCH from an outside hospital with a right lung pneumonia and pleural effusion.He had received amoxicillin, azithromycin and 5 days of high dose ibuprofen prior to being hospitalized at the outside facility.
3 Past Medical History Unremarkable for chronic illnesses No chronic medicationsThere had been no hospitalizations or surgeriesNo known drug allergies
5 Hospital Day 1 Hemoglobin 11.3gm% Hematocrit 32.3 % Started on IV ceftriaxone and vancomycin
6 Hospital Day 2 Right chest tube placed He vomited 15cc of blood and passed melanotic stools during the nightTransferred to the PICUHis H/H fell to 7.4 gm% / 21.7% (admission H/H were 11.3 gm% / 32.3%)Two units PRBCs and 1 unit FFP were givenStarted on IV pantoprazoleon admission 11.3/32.3 ADD TO ADMISSION SLIDE
7 Hospital Day 3 Pediatric GI service consulted Pediatric GI examination Tachypneia, tachycardia and normal BPTenderness in the epigastriumRectal examination was followed by the passage of grossly bloody stoolImpression- gastritis and/or stress ulcerPlan- close observation, consider EGDLIST EXACT VITALSTRY TO GET A BETTER GRASP ON IMPRESSION- DID NOT SEEM SERIOUS AT THE TIME
8 Hospital Day 4 H/H increased to 10.3 gm% / 29.5% Sucralfate slurries were addedDecrease in melanotic stoolsNo additional hematemasisContinued epigastric discomfort
9 Hospital Day 9 The pt. had a 2nd episode of hematemesis (40-50ccs) H/H dropped to 8.5gm% / 25.3 %EGD performed (1st EGD)Blood clots throughout the stomach but no active bleeding2 moderate sized duodenal ulcers(one with a white eschar base and one with an overlying clot)Started on IV pantoprzole and octreotide dripsTransfused 3 units PRBCs & 1 unit of FFPDOSES OF PROTONIX AND OCTREOTIDE
12 Hospital Day 10 The patient became pale, diaphoretic and hypotensive NG tube placed and blood suctionedThe patient was taken for emergency EGD (2nd EGD)
13 Hospital Day 10At EGD the same clean based ulcer with an eschar was seen in the duodenal bulb and in the duodenal sweep a blood clot overlying a moderate sized blood vessel was notedThe area around the blood vessel was injected with 2.5mL of 1:10,000 epinephrineThe area and ulcer base was then gently cauterized with a Gold heater probe
15 Hospital Day 11-16Following the 2nd EGD the patient was transfused with 4 more units of PRBCs. He remained stable with no signs of bleeding.On the 16th day the patient had a third episode of hematemesis (400cc) that required 2 units of PRBCs.A fasting serum gastrin level was normal.Possible surgical intervention was discussed with the family. However, there was no additional evidence of active bleeding.
16 Hospital Day 21Prior to discharge another endoscopy (3rd EGD) was performed. There was no active bleeding, no blood clots and both duodenal ulcers appeared to be healing.Biopsies from the gastric antrum showed chronic gastritis but no Helicobacter pylori.The patient was discharged on high doses of pantoprazole, ranitidine and sucralfate.
18 SummaryDuring his WCH stay our patient received a total of 11 units of PRBCs and 2 units of FFPOn discharge his H/H was 12.6gm%/ 36.8%
19 Follow upAt a clinic visit two weeks after discharge he was stable. There had been no further hematemesis or melena . The H/H was gm% / 42%. He was taking pantoprazole 20 mg tid, ranitidine 75 mg bid and sucralfate 500 mg qid. The same medications and doses were continued except for the sucralfate which was discontinued.At a clinic visit six weeks after discharge he remained asymptomatic. The H/H was 13.2 gm% / 38.5%. The ranitidine was discontinued at the six week visit and the pantopazole was decreased to 20 mg bid.
20 Dieulafoy lesionFirst described by T. Gallard in 1884 and later by G. Dieulafoy in 1896Proposed etiology- an unusually large and tortuous artery that runs in the submucosamassive bleeding occurs when the vessel is exposed or erodes as it approximates the mucosaMost common in the lesser curvature of the stomach, but reported to occur in bronchi and in the esophagus, small and large intestine
21 Accounts for less than 2% of all upper GI bleeds May be underestimated due to difficulty in diagnosisDiagnosis may be complicated due to the intermittent nature of the bleedingFound primarily in adultsTwice as common in men as women
22 Rarely reported in the pediatric population In the English literature, there have been 8 reported pediatric cases, ranging in age from 13 months to 15 yearsTo our knowledge, this is the third pediatric case in the English literature of a small intestinal Dieulafoy lesion.
23 DiagnosisThe diagnosis is established by endoscopy but the lesion can be difficult to identifyThe lesion may be noted as a bleeding arteriole or noted as a clot overlying a vessel (our case)In most cases the surrounding mucosa is normalMultiple endoscopic procedures may be necessary before the lesion is foundThe diagnosis in a few cases has been established by capsule endoscopy, arteriography or endoscopic ultrasound
24 Treatment Endoscopic interventions (most commonly employed) injection of epinephrine or sclerosing agents, thermocoagulation, photocoagulation or band ligationIn our case epinephrine injection and electrocaudery were usedSurgical interventions (less commonly employed)Reserved when endoscopic intervention failsIncludes over-sewing of the lesion or wide resection.Associated with more postoperative complicationsAngiography with embolization has also been used when the lesion is found in the jejunum
25 ConclusionDieulafoy lesions are rare in the pediatric age group and can be difficult to diagnose.Our case illustrates the success of endoscopy for diagnosis and treatment.
26 References1. Pitcher GJ, Bowley DM, Chasumba G, Zuckerman M. Life-threatening haemorrhage from a gastric Dieulafoy lesion in a child with haemophilia. Haemophilia Sep;8(5):2. Lilje C, Greiner P, Riede UN, Sontheimer J, Brandis M. Dieulafoy lesion in a one-year-old child. J Pediatr Surg Jan;39(1):133-4.3. Sweerts M, Nicholson AG, Goldstraw P, Corrin B. Dieulafoy's disease of the bronchus. Thorax Jun;50(6):697-8.4. Anireddy D, Timberlake G, Seibert D. Dieulafoy's lesion of the esophagus. Gastrointest Endosc Jul-Aug;39(4):604.5. Sai Prasad TR, Lim KH, Lim KH, Yap TL. Bleeding jejunal Dieulafoy pseudopolyp: capsule endoscopic detection and laparoscopic-assisted resection. J Laparoendosc Adv Surg Tech A Aug;17(4):6. Murray KF, Jennings RW, Fox VL. Endoscopic band ligation of a Dieulafoy lesion in the small intestine of a child. Gastrointest Endosc Sep;44(3):336-9.7. Meister TE, Varilek GW, Marsano LS, Gates LK, Al-Tawil Y, de Villiers WJ. Endoscopic management of rectal Dieulafoy-like lesions: a case series and review of literature. Gastrointest Endosc Sep;48(3):302-5.8. Linhares MM, Filho BH, Schraibman V, Goitia-Durán MB, Grande JC, Sato NY, Lourenço LG, Lopes-Filho GD. Dieulafoy lesion: endoscopic and surgical management. Surg Laparosc Endosc Percutan Tech Feb;16(1):1-3.9. Driver CP, Bruce J. An unusual cause of massive gastric bleeding in a child. J Pediatr Surg Dec;32(12):10. Avlan D, Nayci A, Altintaş E, Cingi E, Sezgin O, Aksöyek S. An unusual cause for massive upper gastrointestinal bleeding in children: Dieulafoy's lesion. Pediatr Surg Int May;21(5): Epub 2005 Apr 2.