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1 O 2 + FA OH ° + FA ° Singlet Oxygen Hydroxyl Radical PUFA + OH ° PUFA ° + H 2 O PUFA Radical PUFA ° + O 2 PUFAO 2 ° PUFA Peroxide Radical PUFAO 2 ° +

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Presentation on theme: "1 O 2 + FA OH ° + FA ° Singlet Oxygen Hydroxyl Radical PUFA + OH ° PUFA ° + H 2 O PUFA Radical PUFA ° + O 2 PUFAO 2 ° PUFA Peroxide Radical PUFAO 2 ° +"— Presentation transcript:

1 1 O 2 + FA OH ° + FA ° Singlet Oxygen Hydroxyl Radical PUFA + OH ° PUFA ° + H 2 O PUFA Radical PUFA ° + O 2 PUFAO 2 ° PUFA Peroxide Radical PUFAO 2 ° + PUFA PUFAO 2 H + PUFA ° L ipid Hydroperoxide Breakdown Products (toxic) Lipid Peroxidation

2 Factors influencing LPO in parenteral lipid admixtures Oxygen (Ambient) Light Temperature Micronutrients Trace elements (Cu, Fe, Se) Vitamins (E, A, C)

3 days of storage peroxide values [mmol peroxides/L] °C / daylight; with TE 20-30°C / daylight 2-8°C / light-protected with TE 2-8°C / light-protected Steger, Mühlebach JPEN 2000;24:37-41 Lipid peroxidation of AIO admixtures: Influence of trace elements (TE) and storage conditions


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