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September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada.

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Presentation on theme: "September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada."— Presentation transcript:

1 September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada

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3 Denis Grant (Chair) Univ of Toronto ON Stelvio Bandiera UBC, Vancouver BC Jack Bend UWO, London ON Chantal Guillemette Laval Univ, Quebec PQ Malle Jurima-Romet Celerion, Montreal PQ Roger Keefe Imperial Oil, Calgary AB David K. Lee NoAb, Mississauga, ON Tom Massey Queen’s Univ, Kingston ON Eddie Morgan Emory Univ, Atlanta GA Sandy Pang Univ of Toronto, Toronto ON Allan Rettie Univ of Washington, Seattle WA David Riddick Univ of Toronto, Toronto ON Nathalie Rioux Boehringer Ingelheim, Laval PQ Rachel Tyndale Univ of Toronto, Toronto ON Jack Uetrecht Univ of Toronto. Toronto ON Peter Wells Univ of Toronto, Toronto ON

4 Ann Daly – Newcastle University, UK Patrick Dansette - Université Paris, France - Université Paris, France Xinxin Ding – Wadsworth, Albany NY, USA Uwe Fuhr – University Hospital of Cologne, Germany Ron Hines Ron Hines – Medical College of Wisconsin, Milwaukee WI, USA Paul Hollenberg Paul Hollenberg – University of Michigan, Ann Arbor MI, USA Magnus Ingelman-Sundberg Magnus Ingelman-Sundberg – Karolinska Instutute, Stockholm, Sweden Tetsuya Kamataki Tetsuya Kamataki – Inst for Genome Function, Fujisawa, Japan – Inst for Genome Function, Fujisawa, Japan Richard Kim Richard Kim – Univ of Western Ontario, London, ON, Canada Steve Leeder Steve Leeder – Children's Mercy Hospital, Kansas City MO, USA Peter Mackenzie – Flinders University, Adelaide, Australia – Flinders University, Adelaide, Australia Larry Marnett Larry Marnett – Vanderbilt Univ, Nashville TN, USA Urs Meyer Urs Meyer – Biozentrum, Univ of Basel, Basel, Switzerland Franz Oesch Franz Oesch – Univ of Mainz, Mainz, Germany – Univ of Mainz, Mainz, Germany B. Kevin Park - University of Liverpool, Liverpool, UK - University of Liverpool, Liverpool, UK Olavi Pelkonen - University of Oulu, Oulu, Finland - University of Oulu, Oulu, Finland Lance Pohl - NIH/NHLBI, Bethesda, Maryland, USA - NIH/NHLBI, Bethesda, Maryland, USA Rory Remmel - University of Minnesota, Minneapolis, Minnesota, USA - University of Minnesota, Minneapolis, Minnesota, USA Glenn Sipes - University of Arizona, Tucson, Arizona, USA - University of Arizona, Tucson, Arizona, USA Bill Smith (President-Elect) - Pfizer Inc La Jolla Labs, San Diego, California, USA - Pfizer Inc La Jolla Labs, San Diego, California, USA Steve Tannenbaum - MIT, Cambridge, Massachusetts, USA - MIT, Cambridge, Massachusetts, USA Ken Thummel - University of Washington, Washington, USA - University of Washington, Washington, USA Jacques Turgeon - Universite de Montreal, Montreal PQ, Canada - Universite de Montreal, Montreal PQ, Canada Mike Waterman - Vanderbilt University, Nashville, Tennessee, USA - Vanderbilt University, Nashville, Tennessee, USA David Waxman - Boston University, Boston, Massachusetts, USA - Boston University, Boston, Massachusetts, USA Yasushi Yamazoe - Tohoku University, Sendai, Japan - Tohoku University, Sendai, Japan Uli Zanger - Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany - Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany

5 4-6 Short Courses 4-6 Short Courses 3 Keynote Lectures 3 Keynote Lectures 2 Plenary Sessions 2 Plenary Sessions ISSX Awards and Award Lecture ISSX Awards and Award Lecture 8-12 Symposia 8-12 Symposia 4-6 Industry-Sponsored Luncheon Seminars 4-6 Industry-Sponsored Luncheon Seminars 3 Days of Poster Viewing 3 Days of Poster Viewing 1 Poster Awards Session 1 Poster Awards Session 3 Days of Commercial Exhibits 3 Days of Commercial Exhibits ½ Day Free Time ½ Day Free Time Welcome Reception Welcome Reception ISSX Banquet ISSX Banquet

6 Sunday, September 29, 2013 Sunday, September 29, : :00 Staff Prep Monday, September 30, 2013 Monday, September 30, : :00 10:00 - 3:00 PM 09: :00 12: :00 14: :00 18: :15 18:15 – 19:00 19:00 – 21:00 Registration Open ISSX Council Meeting Short Course I Short Course II Short Course III Lunch for Short Course Attendees Short Course IV Short Course V Short Course VI Opening Welcome Address Keynote Lecture 1 Welcome Reception Tuesday, October 1, 2013 Tuesday, October 1, : :00 09:00 – 11:00 11:00 – 11:30 11:30 – 12:30 12:30 – 14:00 14:00 – 16:00 16:00 – 16:30 16:30 – 18:30 Registration Open Plenary Session 1 Refreshment Break ISSX Awards and Award Lecture Lunch Industry Seminars Poster Viewing Exhibits Symposium 1 Symposium 2 Symposium 3 Refreshment Break Poster Viewing Symposium 4 Symposium 5 Symposium 6 Wednesday, October 2, 2013 Wednesday, October 2, : :00 09:00 – 11:00 11:00 – 11:30 11: :30 12: :00 14:00 – 19:00 19: :00 Registration Open Plenary Session 2 Refreshment Break Keynote Lecture 2 Lunch Industry Seminars Poster Viewing Exhibits Free Afternoon ISSX Banquet Thursday, October 3, 2013 Thursday, October 3, : :00 09: :00 11:00 – 11:30 11: :30 12:30 – 14:00 14: :00 16:00 – 16:30 16:30 Registration Open Symposium 7 Symposium 8 Refreshment Break Keynote Lecture 3 Lunch Industry Seminars Poster Viewing Exhibits Symposium 9 Symposium 10 Poster Awards Closing

7 Preliminary topics: Role of inflammation in chemical carcinogenesis Role of inflammation in chemical carcinogenesis Development and uses of stem cell derived hepatocyte-like cells and cultured transformed cells Development and uses of stem cell derived hepatocyte-like cells and cultured transformed cells Utility and challenges of genome-wide association studies in pharmacogenetics research Utility and challenges of genome-wide association studies in pharmacogenetics research Extrapolation from in vitro and cell-based systems to predict in vivo human drug metabolism Extrapolation from in vitro and cell-based systems to predict in vivo human drug metabolism Extrapolation of animal drug disposition studies to humans Extrapolation of animal drug disposition studies to humans Utility of genetically modified animals in human drug disposition studies Utility of genetically modified animals in human drug disposition studies Toxicogenomic profiling: current status and future utility in drug development Toxicogenomic profiling: current status and future utility in drug development Drug-metabolizing enzymes as therapeutic targets Drug-metabolizing enzymes as therapeutic targets Receptor cross-talk in the regulation of drug metabolizing enzyme expression Receptor cross-talk in the regulation of drug metabolizing enzyme expression Metabolomic profiling as a tool for identifying novel drug target interactions Metabolomic profiling as a tool for identifying novel drug target interactions Role of oxidative stress in cell physiology and pathology Role of oxidative stress in cell physiology and pathology Pharmacogenomics and translational medicine: promise and challenge Pharmacogenomics and translational medicine: promise and challenge Effect of natural products on drug disposition Effect of natural products on drug disposition Methods for prediction of drug-drug interactions Methods for prediction of drug-drug interactions Systems biology and xenobiotic-host interactions: concepts and technologies Systems biology and xenobiotic-host interactions: concepts and technologies Impact of advanced genome sequencing technologies on personalized medicine Impact of advanced genome sequencing technologies on personalized medicine Neuronal damage and neuroprotection against chemical insult Neuronal damage and neuroprotection against chemical insult DNA damage and repair mechanisms in cancer risk DNA damage and repair mechanisms in cancer risk Cell type specific cytotoxic mechanisms Cell type specific cytotoxic mechanisms New approaches to the development of biomarkers for drug-induced toxicity New approaches to the development of biomarkers for drug-induced toxicity

8 Members: 500 Non-members: 200 Students: 300 TOTAL1000

9 Oct 2011– May 2012 (24-16 mo) Oct 2011– May 2012 (24-16 mo) MOC/SAB memberships approved and finalized (1 mo) MOC/SAB memberships approved and finalized (1 mo) MOC/SAB meetings/teleconferences/ circulars – scientific program details finalized (7 mo) MOC/SAB meetings/teleconferences/ circulars – scientific program details finalized (7 mo) May 2012 (16 mo) May 2012 (16 mo) Finalized program, speakers and titles sent to SAC Finalized program, speakers and titles sent to SAC SAC approval of program SAC approval of program June – Oct 2012 (16-12 mo) June – Oct 2012 (16-12 mo) Speaker invitations Speaker invitations Identification/approval of satellite meetings Identification/approval of satellite meetings

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11 Shopping Bloor Street Bloor Street Yorkville Yorkville St. Lawrence Market St. Lawrence Market Eaton Centre Eaton Centre Distillery District Distillery District Arts & Culture Art Gallery of Ontario Art Gallery of Ontario Royal Ontario Museum Royal Ontario Museum Toronto Symphony Toronto Symphony Live Theatre Live Theatre Opera Opera Sports: MLB Playoffs?! Sports: MLB Playoffs?! Neighbourhoods Chinatown Kensington Market The Beaches Little Italy Queen Street West Danforth/Greektown Leaside Roncesvalles Village Bloor West Village Walking/Cycling Harbourfront Discovery Walk tours ‘City of Ravines’

12 September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada


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