Presentation on theme: "The Nobel Prize in Physiology or Medicine 2005 Class A Group 4 王彥昇、何長軒、吳庭瑜、呂庭毅、 卓韋儒、林欣聖、林庭蔚、張剛瑋 The discovery of the bacterium Helicobacter pylori and."— Presentation transcript:
The Nobel Prize in Physiology or Medicine 2005 Class A Group 4 王彥昇、何長軒、吳庭瑜、呂庭毅、 卓韋儒、林欣聖、林庭蔚、張剛瑋 The discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease
Drs. Barry Marshall and Robin Warren Robin Warren Barry Marshall Barry Marshall drank the solution with germs caused gastric inflammation cured with antibiotic Koch's postulates proof 1.Proved H. pylori the pathogen 2.Invented C 13 urea breath test 1.Successfully cultivated H. pylori 2.Showed below
Helicobacter Pylori Gram negative Spiral shaped Microaerophilic bacterium 2~4 um Inhabit in stomach and duodenum
Adherence of H. pylori Adhesin - BabA(histo-blood group antigen binding adhesion) - SabA (sialic acidbinding adhesion) LPS(lipopolysaccharide) -- Lex(Lewis x) -- Ley(Lewis y) Lewis blood group antigen Related ABO antigens
Leb BabA Persistence infection and chronic inflammation(gastritis) H. pylori triggers the host to retailor mucosal glycosylation patterns to up-regulate s-Lex H. pylori use BabA for recognition of Leb s-LexSabA Vigorous inflammantory response H. pylori might have gain local advantage In the prepared of escaping of intimate contact with lymphocyte or other defensive cells.
cagA (cytotoxin associated gene A) Cag PAI (Cag pathogenicity island ) a. cagA( exists in 60%~70% H. pylori ) b. TFSS Translate to protein CagA (cytotoxin associated antigen A ) a. a 120–145-kDa protein
IL-12 INF-γ B cell T H 1 activate little B cells INF-γ INF-γ ： 1.Increase antigen presenting of macrophage 2.Attract more macrophage to the epithelial cells ↓ inflammation IL-2 T cell→Tc Macrophage DC= dendritic cell
Dendritic cell IL-10 IL-12 T H 2 cell B cell T H 2 cell release IL-4 ↓ B cell proliferation Stimulate T H 2 cell Inhibit T H 1 cell IL-4 INF-γ Chronic gastritis Macrophage
Acute gastritisChronic gastritis H.Pylori Non-DC-SIGN DC-SIGN EnvironmentTH1 cell TH1&TH2 cell in balance Macrophagemorefewer B celllittleMuch Persistent colonization of Hp in presence of mild gastritis High level of inflammation Comparison between acute and chronic gastritis
Thanks to this pioneering discovery, peptic ulcer disease is no longer a chronic, frequently disabling condition, but a disease that can be permanently cured. Gastric cancer →Nobel prize get!!!!!!!!