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Fidler, I.J., Nat. Rev. Cancer (2003) Road map to cancer metastasis.

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Presentation on theme: "Fidler, I.J., Nat. Rev. Cancer (2003) Road map to cancer metastasis."— Presentation transcript:

1 Fidler, I.J., Nat. Rev. Cancer (2003) Road map to cancer metastasis

2 Thierry, J.P., Nat. Rev. Cancer (2002) Epithelial-to-mesenchymal transition: explaining cancer invasion and metastasis

3 Classification of migration modes Wolf et al., Nat. Cell Biol. (2007); Friedl & Gilmour, Nat. Rev. Mol. Cell Biol. (2009); Friedl & Wolf, J. Cell Biol. (2010)

4 The multiscale tuning model Friedl & Wolf, J. Cell Biol. 2010

5 Collective cell migration Friedl & Gilmour, Nat. Rev. Mol. Cell Biol. (2009)

6 MT1-MMP is required for collective invasion in 3D collagen lattices F-actin Col2 ¾ DAPI Reflection siCtrl siMT1 Wolf et al., Nat. Cell Biol. (2007)

7 Micropatterning * I / II Pseudopod elongation, adhesion, force generation III Focalized proteolysis IV Fibre realignment V Release of microtrack µm Moving fibres * * * Sustained cleavage Zones of physical resistance Proteolytic microtrack Individual and collective cancer cell invasion in 3D ECM F-actin ß1 integrin MT1-MMP Collagenolysis Single-cell migration Friedl & Wolf, Cancer Res. (2008)

8 Drop-onSpheroid injection Variants of the dorsal skin-fold chamber model


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