6ENERGY Fibers contain multiple mitochondria for energy Most fibers have multiple nuclei
7SARCOLEMMA Sarcolemma = muscle fiber membrane Sarcoplasm = inner material surrounding fibers (like cytoplasm)Myofibrils = individual muscle fibers --> made of myofilaments
8Myofibril (Muscle fiber or cell) Contains protein filaments – ACTIN (thin) and MYOSIN (thick)These filaments overlap to form dark and light bands on the muscle fiberA band = dArk • thick (myosin)I band = lIght • thIn (actin)In the middle of each I band are Z lines. A sarcomere is one Z line to the other
9Structure of a Sarcomere (functional unit of a muscle) Actin and Myosin filaments are arranged in an overlapping pattern of light (I bands) and dark (A bands).In the middle of each I band is a line called a Z line.The section of a myofibril from one Z line to the next Z line is the Sarcomere.*The arrangement of these sarcomeres next to each other produces the striations of the skeletal muscle fibers.Note: Each Myofibril is surrounded by a network of channels called Sarcoplasmic Reticulum. Transverse tubules pass through the fibers.
18Muscles & the Nervous System NEUROMUSCULAR JUNCTION - where a NERVE FIBER and muscle fiber come together. A.K.A. Myoneural junction.MOTOR NEURON ENDINGS - nerve fiber caries the impulse that stimulates the muscle fibersMOTOR END PLATE - specialized part of muscle fiber membrane (sarcolemma) located at the neuromuscular junction, has many foldsSYNAPTIC CLEFT - An actual "gap" or cleft which exits between the motor neuron endings and the motor end plate.SYNAPTIC VESICLES - numerous vesicles in motor neuron endings, where neurotransmitters are stored before being released into the synaptic cleft.NEUROTRANSMITTER - substance that is released from nerve endings into synaptic cleft. Stimulates an impulse. In this case, a "muscle impulse". One of the major neurotransmitters is ACETYLCHOLINE. This brings about muscle contractions. ACETYLCHOLINESTERASE is an enzyme that breaks down acetylcholine
20Motor Unit or Neuromuscular Junction 1. Neuron 2. Sarcolemma (or motor end plate) 3. Vesicle 4. Synapse 5. Mitochondria
21Events in a Muscle Contraction A nerve impulse stimulates the release of a neurotransmitter (acetylcholine) from synaptic vesicles into the synaptic cleft.The impulse spreads across the sarcolemma and into the fiber. This impulse causes an increase in the permeability to calcium ions. The S.R. has a high conc. of Ca++.Calcium ions diffuse into the sarcoplasm. The Ca++ causes the formation of "cross bridges" between the actin and myosin filaments.The filaments slide between each other, and this shortens the myofibrils, which in turn shorten the muscle fibers, which shortens the muscle.A "Calcium Pump" returns the CA++ into the S.R. (requires energy- ATP)The enzyme Acetylcholinesterase stops the action of Acetylcholine
22The neurotransmitter that crosses the gap is ACETYLCHOLINE. This is what activates the muscle.Acetylcholine is stored in vesicles
25SLIDING FILAMENT THEORY (MODEL) The theory of how muscle contracts is the sliding filament theory. The contraction of a muscle occurs as the thin filament slide past the thick filaments. The sliding filament theory involves five different molecules plus calcium ions.The five molecules are:myosinactintropomyosintroponinATP
32Threshold Stimulus All-or-None Response Minimal strength required to cause a contraction Motor neuron releases enough acetylcholine to reach thresholdAll-or-None ResponseFibers do not contract partially, they either do or don't
33Motor Unit Recruitment Muscle Tone The muscle fiber + the motor neuron The muscle fiber + the motor neuron Recruitmentmore and more fibers contract as the intensity of the stimulus increasesMuscle ToneSustained contraction of individual fibers, even when muscle is at rest
34Hypertrophy - muscles enlarge (working out or certain disorders) Atrophy - muscles become small and weak due to disuse
35Muscle Cramp - a sustained involuntary contraction Muscle Fatigue - muscle loses ability to contract after prolonged exercise or strainMuscle Cramp - a sustained involuntary contractionOxygen Debt - oxygen is used to create ATP, during exercise you may not have enough oxygen --> this causes Lactic Acid to accumulate in the muscles
36Origin and Insertion Origin = the immovable end of the muscle Insertion = the movable end of the muscle **when a muscle contracts the insertion is moved toward the originThe biceps brachii has two origins (or two heads).
37What is rigor mortis?A few hours after a person or animal dies, the joints of the body stiffen and become locked in place. This stiffening is called rigor mortis. Depending on temperature and other conditions, rigor mortis lasts approximately 72 hours. The phenomenon is caused by the skeletal muscles partially contracting. The muscles are unable to relax, so the joints become fixed in place.
38What is tetanus?Tetanus causes cholinosterase to not break down the acetylcholine in the synapse. This results in a person's muscles contracting and not relaxing.A tetanus shot must be administered shortly after exposure to the bacteria.Once you develop tetanus, there is no cure.