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The Electrolitolysis ( ELLYS ) FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW THERAPEUTIC METHOD Ernesto Fina Dipartimento Nefro-Urologico A.O.R.N.

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Presentation on theme: "The Electrolitolysis ( ELLYS ) FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW THERAPEUTIC METHOD Ernesto Fina Dipartimento Nefro-Urologico A.O.R.N."— Presentation transcript:

1 The Electrolitolysis ( ELLYS ) FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW THERAPEUTIC METHOD Ernesto Fina Dipartimento Nefro-Urologico A.O.R.N. Cardarelli Napoli 76° Congresso Nazionale SIU - Corso CLU

2 ELECTROLYTIC DISSOLUTION OF URINARY STONES O ELECTROLITOLYSIS O ELLYS Direct anodic oxidation Oxidation by born oxigen Protolysis Takes place by creating an electrolytic circuit, who’s ionic medium is the urine,in contact with the positive pole (anode),through:

3 The ELLYS is effective on all types of stones stones “hardness” With a Dissolution rate D. R. ( mg\h ) applied current intensity

4 “Hardness of stones “Hardness” = resistance to electrochemical dissolution It’s inversely proportional to dissolution rate (D.R.) Hardness Dissolution rate

5 Hardness of main stone compounds Tasso di dissoluzione Mg\h

6 Current intensity ( mA ) The dissolution rate ( D.R. ) is directly proportional to the current intensity (C.I.) D.R. C.I. and more specifically to the current density (C.D.),it is to the ratio between C.I.and electrode surface D.R. C.D.

7 Stones submitted to ELLYS Foto 1

8 Foto 2

9 Foto 3

10 Foto 4

11 Foto 5

12 “In vitro”experimentation results The ELLYS is effective against : Urinary stones Crystals and salts Bacteria * * Wong HY and Griffit D.P. : Iontophoresis in Medicine : Possible applications in Urology. Minim. Invasive Therapy ; 1993, 2.51

13 “Ex vivo experimental model on pig bladders

14 “Ex vivo”experimental model on pig bladders

15 Results of “ex vivo trial  C.I.employable without lesions = 30 mA  ELLYS effective at these C.I. values

16 Possible therapeutic applications of ELLYS Stone therapy Therapy of kidney infected cavities Prevention of urolithiasis

17 Equipment for ELLYS Spiral stent Power Supplier ( S.EL.S.) ( battery and electronic circuit) +

18 Spiral stent ( S.EL.S )

19 Stone disease therapy  Non impacted single or multiple stones into inferior calyx or pelvis  Residual fragments to E.S.W.L.  Relapsing stone disease in multitreated patients

20 Prevention of stone disease The ELLYS is very effective on growing crystals through: Spiral miniaturized stent left in cavities (implant) and connected with a battery embedded in a sub- cutaneous pouch

21 Therapy of infections The continous current delivery in a saline solution makes it completely sterile through born Oxygen and Chlorine( Wong e Coll. ) The continous current delivery in a saline solution makes it completely sterile through born Oxygen and Chlorine( Wong e Coll. ) The ELLYS therefore can be employed : To sterilize kidney infected cavities To get the contemporary dissolution and sterilization of infected stones ( struvite )

22 The ELLYS want to realize, with the help of modern technologies, the old dream of the Urologist,that is the total stone disappearance

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