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Elizabeth M. Whitley, DVM, PhD, Dipl. ACVP 1 Isabel Hurtado Rodriguez, DVM, MS, Dipl. ACVIM 2 Amelia S. Munsterman, DVM, MS, Dipl. ACVS 2 1 Department.

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Presentation on theme: "Elizabeth M. Whitley, DVM, PhD, Dipl. ACVP 1 Isabel Hurtado Rodriguez, DVM, MS, Dipl. ACVIM 2 Amelia S. Munsterman, DVM, MS, Dipl. ACVS 2 1 Department."— Presentation transcript:

1 Elizabeth M. Whitley, DVM, PhD, Dipl. ACVP 1 Isabel Hurtado Rodriguez, DVM, MS, Dipl. ACVIM 2 Amelia S. Munsterman, DVM, MS, Dipl. ACVS 2 1 Department of Pathobiology 2 Department of Clinical Sciences College of Veterinary Medicine Auburn University Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

2  5-year-old, male castrated, American quarter horse  Used for roping  Recent, intermittent reluctance to work on the right hand  Recent, unexplained weight loss Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

3  Presented for colic that was non-responsive to Banamine and sedation  Clinical signs:  Dehydration, tachycardia, tachypnea  Copious nasogastric reflux when tubed  Distended small intestine on ultrasound and palpation  Diagnosed a renal mass on ultrasound Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

4 Nephroblastoma  Rare neoplasm in animals other than pigs or chickens  Usually observed in young animals  “Wilms’ tumor” in children 56.htm Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

5 Nephroblastoma  Three different morphologies  Blastemal (undifferentiated, embryonic) cells  Epithelial cells  Mesenchymal cells  Benign or malignant en.wikibooks.org/.../Pregnancy_and_birth Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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10 VimentinDesmin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

11 Smooth muscle actin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

12 Cytokeratin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

13 Basement membrane Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

14  Malignant nephroblastoma, triphasic, kidney, with metastasis to liver, spleen, and mesentery. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

15  Inactivation of the Wilms’ tumor gene (WT1)  WT1 protein is a transcription factor that functions as a tumor suppressor gene ▪ Is expressed during renal and gonadal development  Defects in WT1 gene prevents normal differentiation of metanephric stem cells  Other genetic defects identified in children with Wilms’ tumor ( including WT2, WT3, WT4) Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

16  Thanks to Dr. Eva Sartin, Beth Landreth, Uschi Wolfert for technical assistance in histopathology. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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