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NP Outreach Curriculum in Rheumatology St. Joseph’s Health Care, London, ON Dr. Sherry Rohekar November 12, 2009.

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Presentation on theme: "NP Outreach Curriculum in Rheumatology St. Joseph’s Health Care, London, ON Dr. Sherry Rohekar November 12, 2009."— Presentation transcript:

1 NP Outreach Curriculum in Rheumatology St. Joseph’s Health Care, London, ON Dr. Sherry Rohekar November 12, 2009

2 An Important Issue One of the most common reasons for seeking medical attention, second only to respiratory issues 84% of adults will have low back pain at some point Wide variety of approaches for treatment Suggests that optimal approach is unsure Most episodes are self-limited Some suffer from chronic or recurrent courses, with substantial impact on quality of life

3 Epidemiology Almost any structure in the back can cause pain, including ligaments, joints, periosteum, musculature, blood vessels, annulus fibrosus and nerves Intervertebral discs and facet joints most commonly affected 85% of those with isolated low back pain do not have a clear localization Usually called “strain” or “sprain”  no histopathology, no anatomical location Men and women equally affected Age of onset years

4 Epidemiology Leading cause of work disability in those < 45 years Most expensive cause of work disability in terms of worker’s compensation Multiple known risk factors: Heavy lifting, twisting, vibration, obesity, poor conditioning

5 Deyo R and Weinstein J. N Engl J Med 2001;344: Common Pathoanatomical Conditions of the Lumbar Spine

6 Deyo R and Weinstein J. N Engl J Med 2001;344: Differential Diagnosis of Low Back Pain

7 History Any evidence of systemic disease? Age (especially >50), hx of cancer, unexplained weight loss, IVDU, chronic infection Duration Presence of nocturnal pain Response to therapy Many patients with infection or malignancy will not have relief when lying down Note for arthritis patients – young age, nocturnal pain and worsening with rest are common in AS

8 History Any evidence of neurologic compromise? Cauda equina syndrome is a medical emergency Usually due to tumor or massive herniation compressing the nerves of the cauda equina Urinary retention with overflow, saddle anesthesia, bilateral sciatica, leg weakness, fecal incontinence Sciatica caused by nerve root irritation Sharp/burning pain down posterior or lateral leg to foot or ankle; can be associated with numbness/tingling If due to disc herniation often worsens with cough, sneeze or performing the Valsalva

9 History Any evidence of neurologic compromise? Spinal stenosis is caused by narrowing of the spinal canal, nerve root canals, or intervertebral foramina Most commonly due to bony hypertrophic changes in facet joints and thickening of the ligamentum flavum Disc bulging or spondylolisthesis may also cause Back pain, transient leg tingling, pain in calf and lower extremity that is triggered by ambulation and improved with rest Can differentiate from vascular claudication through detection of normal arterial pulses on exam

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11 Physical Examination Inspection of back and posture (ie. Scoliosis, kyphosis) Range of motion Palpation of the spine (vertebral tenderness sensitive for infection) If high suspicion of malignancy, do a breast/prostate/lymph node exam Peripheral pulses to distinguish from vascular claudication

12 Physical Examination Straight leg raise: for those with sciatica or spinal stenosis symptoms Patient supine, examiner holds patient’s leg straight Elevation of less than 60 degrees abnormal and suggests compression or irritation of nerve roots Reproduces sciatica symptoms (NOT just hamstring) Ipsilateral straight leg raise sensitive but not specific for herniated disk Crossed straight leg raise (symptoms of sciatica reproduced when opposite leg is raised) insensitive byt highly specific

13 Physical examination Neurologic examination L5: ankle and great toe dorsiflexion S1: plantar flexion, ankle reflex Dermatomal sensory loss L5: numbness medial foot and web space between 1 st and 2 nd toes S1: lateral foot/ankle

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15 Imaging AP and lateral L-spine if no clinical improvement after 4-6 weeks Guidelines for American College of Physicians and American Pain Society: “Clinicians should not routinely obtain imaging or other diagnostic tests in patients with nonspecific low back pain” Do perform x-rays if: fever, unexplained weight loss, hx of cancer, neurologic deficits, EtOH, IVDU, age 50, trauma, immunosuppression, prolonged steroid use, skin/urinary infection, indwelling catheter

16 Imaging CT and MRI More sensitive for detection of infection and cancer than plain films Also able to image herniated discs and spinal stenosis, which cannot be appreciated on plain films Beware: herniated/bulging discs often found in asymptomatic volunteers  may lead to overdiagnosis/overtreatment MRI better than CT for detection of infection, metastases, rare neural tumours

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18 Natural History Most recover rapidly 90% of patients seen within 3 days of symptom onset recovered within 2 weeks Recurrences are common Most have chronic disease with intermittent exacerbations Spinal stenosis is the exception  usually gets progressively worse with time

19 Therapy Non-specific low back pain Few RCTs; methodology of studies generally poor quality NSAIDs and muscle relaxants good for symptomatic relief Try giving regular rather than prn Spinal manipulation (ie. chiropractic) of limited utility in studies Should recommend rapid return to normal activities with neither bed rest nor exercise in the acute period Bed rest found to not improve and may delay recovery Exercises not useful in acute phase; use in chronic

20 Therapy Nonspecific low back pain Traction, facet joint injections, TENS ineffective or minimally effective Systematic reviews of acupunture have shown little benefit ? Massage therapy  some promising results Surgery only effective for sciatica, spinal stenosis or spondylolisthesis

21 Therapy Herniated intervertebral discs Nonsurgical treatment for at least a month Exceptions: cauda equina syndrome, progressive neurologic deficits Early treatment same as for nonspecific low back pain, but may need short courses of narcotics for pain control Bed rest not useful Some patients benefit from epidural corticosteroid injections If severe pain, neurologic defecits  MRI and consider surgery

22 Therapy Spinal stenosis Physiotherapy to reduce risk of falls Analgesics, NSAIDs, epidural corticosteroids (no clinical trials) Decompressive laminecotomy Spinal fusion + decompression if there is additional spondylolisthesis Symptoms often recur, even after successful surgery

23 Therapy Chronic low back pain Intensive exercise improves function and reduces pain, but is difficult to adhere to Anti-depressants: many with chronic low back pain are also depressed ? Maybe for those without depression (tricyclics) Opiates Small RCT showed better effect on pain and mood than NSAIDs No improvement in actity Significant side effects: drowsiness, constipation, nausea

24 Therapy Chronic low back pain Referral to multidisciplinary pain center Cognitive-behavioural therapy, education, exercise, selective nerve blocks Surgical procedures rarely helpful

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26 Introduction Spondyloarthritis Refers to inflammatory changes involving the spine and the spinal joints. Remember – can sometimes have peripheral arthritis without spinal symptoms! Seronegative Spondyloarthritis Absence of Rheumatoid Factor Psoriatic Arthritis Ankylosing Spondylitis Reactive Arthritis Enteropathic Arthritis Undifferentiated Spondyloarthropathy

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29  How do you differentiate inflammatory from mechanical back pain?

30 Inflammatory vs. Mechanical Back Pain Inflammatory Age of onset < 40 Insidious onset > 3 months duration > 60 min am stiffness Nocturnal pain Improves with activity Tenderness over SI joints Loss of mobility in all planes Decreased chest expansion Unlikely to have neurologic deficits Mechanical Any age Acute onset < 4 weeks duration < 30 min am stiffness No nocturnal pain Worse with activity No SI joint tenderness Abnormal flexion Normal chest expansion Possible neurologic deficits

31 Clinical Features

32 Sacroiliitis Usually bilateral and symmetric Initially involves the synovial-lined lower 2/3 of the SI joint Earliest change: erosion on the iliac side of SI joint (cartilage is thinner) Could cause “pseudowidening” of SI joint Bony sclerosis, then complete bony ankylosis or fusion

33 Spinal Involvement

34 Gradual ossification of the outer layers of the annulus fibrosis (Sharpey’s fibers) form interverterbral bony bridges Called syndesmophytes Fusion of the apophyseal joints and calcification of the spinal ligaments along with bilateral syndesmophyte formation can result in “bamboo spine”

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38 Enthesitis Enthesis: site of insertion of ligament, tendon or articular capsule into bone Enthesitis: inflammation of enthesis resulting in new bone formation or fibrosis Common sites: SI joints, intervertebral discs, manubriosternal joints, symphysis pubis, iliac crests, trochanters, patellae, clavicles, calcanei (Achille’s or plantar fasciitis)

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40 More Than Just Back Pain... “ANK SPOND” AAortic insufficiency, ascending aortitis, conduction abnormalities, pericarditis NNeurologic: atlantoaxial subluxation and cauda equina syndrome KKidney: amyloidosis, chronic prostatitis SSpine: Cervical fracture, spinal stenosis, spinal osteoporosis

41 More Than Just Back Pain... PPulmonary: upper lobe fibrosis, restrictive changes OOcular: anterior uveitis (25-30% of patients) NNephropathy (IgA) DDiscitis or spondylodiscitis Also: microscopic colitis in terminal ileum and colon (30-60%)

42 More Than Just Back Pain... Remember that patients with AS can also have a peripheral arthritis Usually an oligoarthritis of the lower extremities Occasionally, patients will present with peripheral arthritis before they have back complaints

43 Physical Exam Schober test Detects limitation in forward flexion of the lumbar spine Place mark at dimples of Venus (or level of the posterio superior iliac spine) and another 10 cm above, at the midline Ask patient to maximally forward flex with locked knees Measure should increase from 10 cm to at least 15 cm

44 Modified Schober Test

45 Making The Diagnosis

46 Treatment Physiotherapy for all Maintains good posture Maintains chest expansion Minimizes deformities

47 Treatment NSAIDs Good for mild symptoms Potentially disease modifying Indomethacin seems to work the best Beware of side effects, especially gastrointestinal disease

48 Treatment DMARDs Sulfasalazine mg bid Seems to be the most effective for spinal symptoms Methotrexate mg weekly For patients with prominent peripheral arthritis Doesn’t work very well for spinal symptoms

49 Treatment Steroids Not very effective at all in AS Local injections for enthesitis or peripheral arthritis Anti-TNFα agents Remicade (infliximab), Enbrel (etanercept) and Humira (adalimumab) Very useful for treating symptoms, improving ROM, improving fatigue Hopefully disease-modifying...

50 Any questions?


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