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 Aaron Warning and Megan Anderson. Use dates back to the stone age Popular: easy access and few documented negative side effects Effects: ↑ heart rate,

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Presentation on theme: " Aaron Warning and Megan Anderson. Use dates back to the stone age Popular: easy access and few documented negative side effects Effects: ↑ heart rate,"— Presentation transcript:

1  Aaron Warning and Megan Anderson

2 Use dates back to the stone age Popular: easy access and few documented negative side effects Effects: ↑ heart rate, ↑ respiration rate, psychotropic effects Nehlig, Astrid; Daval, JL.; Debry, G. Effects of Coffee on the Central Nervous System. Brain Res Rev. 1992, Volume 17,

3 ChemDraw (convert name to structure)

4  Caffeine stimulates the nervous system  It binds to adenosine receptors on neurons in the brain  Adenosine receptors: normally causes you to feel tired and slows down the nervous system  If caffeine binds to them = opposite effect Fisone, G; Borgkvist, A; Usiello, A. Caffeine as a psychomotor stimulant: mechanism of action. CMLS 2003, Volume 61,

5  No RDA for caffeine  UL is mg/day  No Adequate Intake established  Negative side effects: heart rate, anxiety, depression, insomnia, nausea, and vomiting  Lethal dose is 10g Lindskog, M; Svenningsson, P; Pazzi, L; Kim, Y; Fienberg, A; Bibb, J; Fredholm, B; Nairn, A; Greengard, P; Fisone, G. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 2002, Volume 418,

6 Spectral Database for Organic Copounds SBDS. bin/direct_frame_disp.cgi?sdbsno=1898 (accessed March 5, 2014).

7 WinChembase. (accessed March 5, 2014)

8 Solvent: water Caffeine: max wavelength: 272nm Spectral Database for Organic Copounds SBDS. bin/direct_frame_disp.cgi?sdbsno=1898 (accessed March 5, 2014).

9 1 2 3 Spectral Database for Organic Compounds SBDS. bin/direct_frame_disp.cgi?sdbsno=1898 (accessed March 5, 2014)

10  Biosynthesis v. Synthetic Synthesis  Synthetic more in energy drinks  Synthetic is cheaper and faster  Natural: found more in tea and coffee  Natural is buffered with over 500 plant molecules o Slower acting o More expensive offee-with-your-Council.aspx Ashihara, Hiroshi; Purine metabolism and the biosynthesis of caffeine in mate leaves. Phytochemistry 1993, Volume 33,

11 Ashihara, Hiroshi; Montiero, Ana Maria; Gillies, Fiona M; Crozier, Alan; Biosynthesis of Caffeine in Leaves of Coffee. Plant Physiol. 1996, 111, ​

12 N-methyl nucleosidase (catalyst) Xanthosine

13 SAM SAH

14 Why is caffeine produced in plants? -Caffeine is a naturally occurring pesticide Looser, Elizabeth; Baumann, T.W; Wanner, H; The biosynthesis of caffeine in the coffee plant. Phytochemistry 1974, Volume 13,

15  Continued abuse  Potential use in fighting cancer  Market will shift toward synthetic caffeine

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