Presentation on theme: " Aaron Warning and Megan Anderson. Use dates back to the stone age Popular: easy access and few documented negative side effects Effects: ↑ heart rate,"— Presentation transcript:
Aaron Warning and Megan Anderson
Use dates back to the stone age Popular: easy access and few documented negative side effects Effects: ↑ heart rate, ↑ respiration rate, psychotropic effects Nehlig, Astrid; Daval, JL.; Debry, G. Effects of Coffee on the Central Nervous System. Brain Res Rev. 1992, Volume 17,
ChemDraw (convert name to structure)
Caffeine stimulates the nervous system It binds to adenosine receptors on neurons in the brain Adenosine receptors: normally causes you to feel tired and slows down the nervous system If caffeine binds to them = opposite effect Fisone, G; Borgkvist, A; Usiello, A. Caffeine as a psychomotor stimulant: mechanism of action. CMLS 2003, Volume 61,
No RDA for caffeine UL is mg/day No Adequate Intake established Negative side effects: heart rate, anxiety, depression, insomnia, nausea, and vomiting Lethal dose is 10g Lindskog, M; Svenningsson, P; Pazzi, L; Kim, Y; Fienberg, A; Bibb, J; Fredholm, B; Nairn, A; Greengard, P; Fisone, G. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 2002, Volume 418,
Spectral Database for Organic Copounds SBDS. bin/direct_frame_disp.cgi?sdbsno=1898 (accessed March 5, 2014).
WinChembase. (accessed March 5, 2014)
Solvent: water Caffeine: max wavelength: 272nm Spectral Database for Organic Copounds SBDS. bin/direct_frame_disp.cgi?sdbsno=1898 (accessed March 5, 2014).
1 2 3 Spectral Database for Organic Compounds SBDS. bin/direct_frame_disp.cgi?sdbsno=1898 (accessed March 5, 2014)
Biosynthesis v. Synthetic Synthesis Synthetic more in energy drinks Synthetic is cheaper and faster Natural: found more in tea and coffee Natural is buffered with over 500 plant molecules o Slower acting o More expensive offee-with-your-Council.aspx Ashihara, Hiroshi; Purine metabolism and the biosynthesis of caffeine in mate leaves. Phytochemistry 1993, Volume 33,
Ashihara, Hiroshi; Montiero, Ana Maria; Gillies, Fiona M; Crozier, Alan; Biosynthesis of Caffeine in Leaves of Coffee. Plant Physiol. 1996, 111,
N-methyl nucleosidase (catalyst) Xanthosine
Why is caffeine produced in plants? -Caffeine is a naturally occurring pesticide Looser, Elizabeth; Baumann, T.W; Wanner, H; The biosynthesis of caffeine in the coffee plant. Phytochemistry 1974, Volume 13,
Continued abuse Potential use in fighting cancer Market will shift toward synthetic caffeine