3Synthetic Analog Problem DEA Temporary Placement of JWH-018, JWH-073, JWH-200, CP47,497 and CP47,497 C8 homolog, MDPV, Mephedrone, Methylone on Schedule 1H.R. 1254: Synthetic Drug Control Act of 2011AK S 17: Classifies certain synthetic cannabinoids as schedule IIA controlled substances.AL H 158, S 207 and S 208: Relates to schedule I controlled substances; provides legislative findings relating to controlled substance analogs; adds cathinone compounds, certain named chemical compounds of synthetic cannabinoids, and controlled substance analogs to the schedule I controlled substances list subject to regulation and penalties in the same manner as other controlled substances.AZ S 1043: Relates to dangerous drugs; relates to definition.AZ H 2388: Adds AM-2201 and JWH-122 to the definition of “dangerous drugs” and to schedule I. Relates to authority to define the chemical composition of controlled substances included in drug schedules; provides for authority to include chemical variations of those substances as necessary; provides consideration of a substance’s potential for abuse, pharmacological effect, current scientific knowledge and the risk to public health; requires written report; exempts the board of pharmacy from rulemaking requirements.CA A 2420: Provides that every person who possesses, under circumstances that do not include possession for sale as proscribed pursuant to existing law, 28.5 grams or less of any synthetic cannabinoid or any synthetic stimulant compound, or any synthetic stimulant derivative is guilty of an infraction punishable by a specified fine.HI S 1305: Adds HU-210, JWH-018, JWH-073 to controlled substances provisions.
15DiscovIR-GC™ The Solution for Designer Drugs GC typicalStep #1 Separation by Gas ChromatographyStep #2 Controlled Deposition - unique solid phase deposition.Step #3 Chemical Identification - using FTIR specificity (positional and stereoisomers)1515
18GC-IR System opticsSample streams onto cryogenic disk surface,where it freezes. Disk turns slowly, carries deposit into IR beam in 45 seconds. Continuous track of deposit on disk, IR spectrum every ½ second. All solvent removed, chromatograms generated from the IR spectra in real time.
20Disc Track Pointer Infrared beam fixed in position ZnSE Disc rotates Start Sample 2 RT= 0.0 minEnd Sample 2 RT= 20.0 minZnSE Disc rotatescounterclockwiseRecords linear positionand rotary position forFor every spectra
21Sample deposit ZnSe window Cryogenic LN2IR DetectorPCBInterferometerABB BomemM C TSample deposit ZnSe windowIdentify labeled elementsLN2 for cooling sample disk & Purge non vacuum optical pathWeighted cap to slightly pressurize N2 to drive purgeElectronics Board7 Proportional Integral Temp Controllers & Many temperature sensors2 Stepping motors for rotary and linear disk motion to create phonograph spiralRoughing and Diffusion pump controlCommunicationsVacuum gaugingonboard processor for control when PC is disconnected / buzyIR Microscope Optics pathInterferometerCollimated path through windows into vacuum chamberParabolic first surface aluminum mirrors100 micron spot sizeMCT Cryogenic DetectorVacuumchamberPrecision Vacuum BackplateOptical path21
28QA/QC / Performance Qualification Voltage check to ensure detector is working properlyNoise check to ensure proper signal/noise ratioNIST traceable polystyrene scan is performedA test mix (amphetamine, phentermine, pseudoephedrine, caffeine, cocaine and alprazolam) enables :GC check (proper separation)IR detector (proper identification)
30Typical Case Work Sample Preparation Sample can be extracted/prepared as if analyzing via GC/MSMeOH (dilute and shoot type)Basic CHCl3, Basic Hex, Acidic CHCl3Acidic HexNormal GC/MS vials can be usedno real change of procedure needs to be employed
55Most clandestine tablets are mixtures Can obtain an infrared spectra for each componentWith the DB-35 column can separate BZP, TFMPP and MDMA (see figures 4-7)Isomer determination for MDMA, TFMPP and CPP (to name just a few)
56Exhibit containing BZP, TFMPP, MDMA and Caffeine
57Clandestine Tablet: Containing BZP, TFMPP, MDMA and Caffeine
58Why use DiscovIR-GC?Resolve and identify mixed analytes in a single instrument and procedure.GC-FTIR provides two analytical methods in one operation.High resolution solid phase spectraSelf-cleaning IR disk. No need to manually clean off old samples.Automatic operation up to 50 hours: Autosampler-compatible.Spectral identification library software.Nanogram sensitivity.Flow splitting: can interface with existing GC–MS instrumentation.Real-time or post-run data collection. Allows re-analysis of deposited samples
59Substances Routinely Analyzed via GCIR system Methamphetamine (includes clan lab, powder and residues)AmphetamineCodeine cough syrupHeroinMorphine (residues from spoons, straws, syringes etc)CocaineClandestine tabletsOxycodone (residues from spoons, straws, syringes, etc)Tryptamines and phenethylaminesBath SaltsCannabinoids