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PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol PBS 10 mg/kg caffeine 10 mg/kg paracetamol + 10 mg/kg caffeine.

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Presentation on theme: "PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol PBS 10 mg/kg caffeine 10 mg/kg paracetamol + 10 mg/kg caffeine."— Presentation transcript:

1 PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol PBS 10 mg/kg caffeine 10 mg/kg paracetamol + 10 mg/kg caffeine 50 mg/kg paracetamol + 10 mg/kg caffeine 100 mg/kg paracetamol + 10 mg/kg caffeine 200 mg/kg paracetamol + 10 mg/kg caffeine PBS Paracetamol 10 mg/kg caffeine Paracetamol + 10 mg/kg caffeine 5 Response Latency (s) * * * * * * * * * * (A) Time (min) * * (B) Response Latency (s) 5 # # # * (C) Dose of paracetamol (mg/kg) Response Latency (s)

2 PBS 50mg/kg paracetamol 3mg/kg SCH mg/kg paracetamol + 3mg/kg SCH58261

3 PBS 10 mg/kg paracetamol 20 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol PBS 10 mg/kg caffeine 50 mg/kg paracetamol + 10 mg/kg caffeine 100 mg/kg paracetamol + 10 mg/kg caffeine 200 mg/kg paracetamol + 10 mg/kg caffeine PBS Paracetamol 10 mg/kg caffeine Paracetamol + 10 mg/kg caffeine Response Latency (s) * * * * * * * (B) Time (min) Response Latency (s) * * * * * (A) Time (min) * * * * * * * # Dose of paracetamol (mg/kg) (C)

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