Download presentation

Presentation is loading. Please wait.

Published bySophia Bell Modified over 2 years ago

1
The Effect of Caffeine on Neurological Dopamine Production Process Dynamics & Control October 13 th, 2004 Student Name 1 Student Name 2

2
Presentation Outline Introduction Simulation Assumptions Process Outcomes Laplace via Maple Matlab Simulink Conclusion

3
What is Caffeine? The most commonly used neurological drug worldwide trimethylxanthine, (C 8 H 10 N 4 O 2 ) bitter tasting white powder Retrieved from: www.cs.virginia.edu/.../ caffeine-molecule.gif

4
Common Substances Coffee, tea, soft drinks, and pain medication Caffeine Content: Brewed coffee: 40-180 mg Black Tea: 20-100 mg Excedrin: 65 mg Mountain Dew: 55 mg Green Tea: 8-36 mg

5
What is Dopamine? Neurotransmitter Movement Thought processes Emotions Pleasure “Rewards” centers of the brain Retrieved from: http://www.bip.bham.ac.uk/osmart/msctox/

6
The Relationship Between Caffeine and Dopamine Caffeine has ½ life of ~6 hours in a healthy person Enters Digestive tract Some caffeine is lost in liver Remainder enters bloodstream Caffeine enters the brain Stimulates excessive dopamine release Blocks uptake receptors

7
Ultimate Response:

8
Simulation Assumptions Body consists of 3 tanks Stomach, Liver, and Brain Flow rates, tank volumes and density remain constant Dopamine production is a first order chemical reaction Caffeine→Dopamine

9
Initial Conditions F1F1 25 dL/s F2F2 20 dL/s F3F3 0.0001 dL/s F4F4 F5F5 0.05 dL/s k1k1 0.250 mol-dL -1 s -1 k2k2 0.125 mol-dL -1 s -1 VsVs 5 dL VlVl 4 dL VbVb 2 dL

10
Simulation Process C i,caf., F 1 Stomach: C 1, V s F 2, C 1 C 3, F 3, D 3 Liver: D 2, C 2, V l Brain: D 5, C 5, V b F 4, C 4, D 4 F 5, D 5 Caffeine Dopamine r b =k 1 C 5

11
Focus Amount of Dopamine produced as a function of input Caffeine

12
Mass Balances: Stomach C i,caf., F 1 Stomach: C 1, V s F 2, C 1 Equation 1. Stomach Mass Balance (Caffeine)

13
Mass Balance: Liver F 2, C 1 C 3, F 3, D 3 Liver: D 2, C 2, V l F 4, C 4, D 4 F 5, D 5 Equation 2. Liver Mass Balance (Caffeine) Equation 3. Liver Mass Balance (Dopamine)

14
Mass Balance: Brain Brain: D 5, C 5, V b F 4, C 4, D 4 F 5, D 5 Caffeine Dopamine r b =k 1 C 5 Equation 4. Brain Mass Balance (Caffeine) Equation 5. Brain Mass Balance (Dopamine)

15
Laplace Transform: Steady State S-Domain t-Domain =C i,caf { }

16
Caffeine Impulse Function

17
Caffeine Unit Step Function

18
Caffeine at Steady-State

19
Dopamine at Steady State

20
Dopamine Unit Step Function

21
Dopamine Impulse Function

22
Simulink Unit Step Function For Caffeine

23
Simulink Unit Step Function For Dopamine

24
Simulink Impulse Function for Caffeine

25
Simulink Impulse Function for Dopamine

26
Conclusion Achieved anticipated results in the theoretical process Possible differences in real process Suggestions Thanks to Dr. Rodgers

27
Questions?

Similar presentations

OK

Main types of drugs are: Stimulants such as caffeine speed up our reaction time and make us more alert. Depressants such as alcohol slow down our reaction.

Main types of drugs are: Stimulants such as caffeine speed up our reaction time and make us more alert. Depressants such as alcohol slow down our reaction.

© 2018 SlidePlayer.com Inc.

All rights reserved.

Ads by Google

Ppt on three allotropes of carbon Ppt on class 10 hindi chapters books Ppt on micro windmills Ppt on channels of distribution in japan Nokia acquired by microsoft ppt online Ppt on musical instruments in hindi Ppt on blood stain pattern analysis terminology Ppt on statistics and probability books Ppt on programmable logic arrays Ppt on self development charter