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Preventative and Therapeutic Treatment of Resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models Bradford Greaves.

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Presentation on theme: "Preventative and Therapeutic Treatment of Resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models Bradford Greaves."— Presentation transcript:

1 Preventative and Therapeutic Treatment of Resveratrol on Alzheimer’s Disease using CL2006 and CL4176 C. elegan models Bradford Greaves

2 Need

3 The APP Processing Senile Plaques Modified from Laurén et al., Nature (2009) Figure 1 Resveratrol Promotes Clearance of Alzheimer’s Disease Amyloid- Peptides, Marambaud 2005 The β amyloid peptide can act as a modular aggregation domain, Link 2008

4 Alzheimer’s Disease cont.

5 Oxidative Damage

6 Purpose To preventatively and therapeutically treat Alzheimer’s Disease with resveratrol using CL2006 and CL4176 C. elegan models

7 Hypothesis Alternate Hypothesis: Both preventive and therapeutic treatment of resveratrol on CL2006 will lead to a decrease in amyloid beta production and for CL4176 there will be a delay of the onset of paralysis. Null Hypothesis: There will be no change in amyloid beta production nor paralysis with the addition of resveratrol.

8 Resveratrol’s Coloration With Alzheimer’s Disease

9 Figure 2 Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans, Gutierrez-Zepeda 2005 Transgenic C. elegans as a Model in Alzheimer’s Research, Wu 2005

10

11

12 Do Ability CL2006 and CL4176: Staining and Paralysis Control food and Resveratrol available Fluorescent Microscope at school

13 Bibliography Bundschuh, K. "The worm in humans." 11 Nov Biotechnology and Life Sciences in Baden-Württemberg. 6 May Cheng, Louse. “Compound in Red Wine May Fight Alzeimer’s.” WebMD. 4 Nov Apr http://www.webmd.com/alzheimers/news/ /compound-in-red-wine-may-fight-alzheimer>. Duchen, Michael R. "Roles of Mitochondria in Health and Disease." Whereas some of the genes identified in the control of longevity appear to target mitochondria or at least to alter antioxidant defenses of the cell (Duchen, Diabetes. 7 May Halliwell, Barry, and John M.C. Gutteridge. Free Radicals in Biology and Medicine. 3rd ed. New York: Oxford UP, Lagouge, Marie, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip Lambert, Peter Elliott, Bernard Geny, Markku Laakso, Pere Puigserver, and Johan Auwerx. "Resveratrol Improves Mitochondrial Function and Protects Against Metabolic Disease by Activating SIRT1 and PGC-1a." Cell (2006). 20 May Lenker, David P. Professional Guide to Diseases. 8th ed. New York: Williams & Wilkins., 2005 Marambaud, Phillipe. Wine Compound May Help Cut Risk of Alzheimer’s Disease. 16 Nov Apr http://www.sciencedaily.com/releases/2008/06/ htm>. McKenzie, Maureen A. "Insulin Receptor-Like Protein." Patent Storm. 5 Oct Apr O,Neill, Bill. "In Methuselah’s Mould." Feature 2 (2004): PLoS Biology..http://www.culturagalega.org/imaxes/docs/plos_lonxevidade.pdf>. "Resveratrol Studies Suggest Broad Implications for SIRT1 Activation,in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease ( whether any of the Company's product ca...)." Bio-Medicine - latest biology and medical news/technology. 26 June Apr Rogers, Kara, ed. "Alzheimer's Disease." Encyclopædia Britannica. 15th ed Society for Neuroscience. "Grape Seed Extract May Reduce Cognitive Decline Associated With Alzheimer's Disease." ScienceDaily 18 June April 2009.


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