Presentation on theme: "Bridging Eastern and Western Medicine Approaches for Treating Cancers"— Presentation transcript:
1 Bridging Eastern and Western Medicine Approaches for Treating Cancers Dr. Baisong Zhong Ph.D, L.Ac, MD(China)WWW: Easternbalancetcm.com
2 Traditional Chinese Medicine (TCM), developed over a period of at least 3000 years, is becoming more acknowledged and accepted in the West, as more people are becoming familiar with the use of Chinese herbs, acupuncture, Tai Ji, and Tuina (Chinese massage). More and more physicians are making referrals to practitioners of Chinese Medicine for difficult conditions such as generic pain, postoperative issues, chemotherapy nausea and vomiting, headache, asthma, diabetes, low immune function and drug addictions.
3 Differences between Mainstream Medicine and TCM Treatment for Cancers (1)The different etiology, pathology between mainstream medicine and TCM for cancersTCMWestern MedicineVital Qi deficiency withphlegm accumulation and blood stasisCancer occurs when cells divide uncontrollably. These abnormal cells can invade nearby tissues or travel to distant sites by entering the bloodstream or lymphatic system
4 (2) The other differences Differences between Mainstream Medicine and TCM Treatment for CancersTCMMainstream MedicineTCM integrated with Mainstream MedicineDiagnostic focusIndividual personal whole body, macrocosmicGroup human local, microcosmicWhole body and local, macrocosmic andmicrocosmicAnti-cancersHerbs directly kill cancers, and with acupuncture help regulate immune function. There is longer effect.Surgery, chemo-radiotherapy stronger in directly killing cancers. There is shorter effect.Comprehensive --kills cancers and regulates immune function. Best in effectiveness.Relieve symptomsRelieves symptoms of whole body.Improves single symptoms.Comprehensive ReliefImprovement of life qualityExcellentSignificant side effectsFairConcurrent effectsGoodLong term effects
5 2. The accessory therapy of TCM Research studies show that TCM can directly inhibit carcinoma. Some herbs, such as Bai Hua She She Cao (Herba Hedyotidis Diffusae), Xiang He Cao (Herba Agrimoniae) and Jiang Huang (Rhizoma Curcumae Longae), E Zhu (Rhizoma Curcumae Ezhu)(1) have a relatively strong in vitro inhibitory effect against carcinoma cells. However, TCM has a more obvious function as an accessory therapy in clinic。It may improve the nutrition of the patients before their surgery, helping them pass through the surgical process. Post operative patients may heal quicker through acupuncture and the use of Chinese herbs that tonify Qi and blood, Qi and Yin, as well as stomach and spleen.
6 Cell Viability (%) Dose of ZY (mg/ml) 07-20-09 WM35 WM793 A375 MeWo Skmel2SB2ZY1ZY2ZY4ZY11MCF7MKMKMKMKDose of ZY (mg/ml)
10 Cancer Tree, Happy Tree, Tree of Joy Xi Shu Guo（Camptotheca acuminata)COMMON NAMESCancer Tree, Happy Tree, Tree of JoyCompounds: camptothecine, venoterpine, 10-hydroxycamptothecine,10—methoxycamptothecine, betulic acid,vincoside-lactam.Nature and Flavor: cold, bitter, toxic.Functions: strongly remove blood stasis, resolve nodules and anti-cancers.Indications: used for gastric cancer, colorectal cancer, choriocarcinoma, lymphosarcoma, acute and chronic leukemia, psoriasis, and schistosomiasis caused hepatosplenomegaly. Findings of numerous researches with xi shu have demonstrated that the extracts obtained from this tree inhibit tumors or cancerous growth. It is interesting to note that many anti-cancer medications have been developed from camptothecin.
11 It has been proved that camptothecine possesses cytostatic as well as anti-tumour actions. However, it is also somewhat noxious. The herb’s anti-cancer actions is owing to the exceptional competence of camptothecine as well as associated compounds to slow down the production of the nuclear DNA topoisomerase I enzyme, which actually disrupts the reproduction as well as duplication of cancerous cells. Two such drugs have been approved for sale and use by the Food and Drug Administration (FDA).Dosage: 3-9gZi Sha Shu(Taxaceae, Taxus)COMMON NAMESPurple bean TreeCompounds: paclitaxelNature and Flavor: cold, bitter, toxic.Functions: Remove blood stasisIndications: Cancers, including breast cancer,ovarian cancer, lung cancers.
12 Presently, barring its importance as a source for taxol (a brand for the anti-cancer drug paclitaxel),As mentioned earlier, the bark of the Pacific yew is a natural source of taxol - a medicine that is used for treating different types of cancers, especially breast and ovarian cancer.Paclitaxel is one of several cytoskeletal drugs that target tubulin. Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division. Unlike other tubulin-targeting drugs such as colchicine that inhibit microttububule assembly, paclitaxel stabilizes the microtubule polymer and protects it from disassembly. Chromosomes are thus unable to achieve a metaphase spindle configuration. This blocks progression of mitosis, and prolonged activation of the mitotic checkpoint triggers apoptosis or reversion to the G-phase of the cell cycle without cell division.The ability of paclitaxel to inhibit spindle function is generally attributed to its suppression of microtubule dynamics, but recent studies have demonstrated that suppression of dynamics occurs at concentrations lower than those needed to block mitosis. At the higher therapeutic concentrations, paclitaxel appears to suppress Paclitaxel
13 microtubule detachment from centrosomes, a process normally activated during mitosis. The binding site for paclitaxel has been identified on the beta-tubulin subunit.(http://en.wikipedia.org/wiki/Paclitaxel)Chang Chun Hua(Catharanthus roseus）COMMON NAMESForever Spring flowerNature and Flavor: cold, bitter, toxicFunctions: Remove blood stasisIndications: anti-cancers and hypertensionCompounds: vinblastine, leurocristine, ajmalicine, lochneridine,lochnericine, carharosinTubulin is a structural protein that polymerizes to microtubules.The cell cytoskeleton and mitotic, among other things, are made of microtubules. Vincristine binds to tubulin dimers, inhibiting assembly of microtubule structures. Disruption of the microtubules arrests mitosis in metaphase. Therefore, the vinca alkaloids affect all rapidly dividing cell types including cancer cells, but also those of intestinal epithelium and bone marrow. Vincristine was approved by the FDA in July 1963 as Oncovin. (http://en.wikipedia.org/wiki/Vincristine).Dosage: 6-15gleurocristine
14 Significantly lower tumor weights and volumes Drug From Chinese ‘Thunder God Vine’ [Lei Gong Teng] Slays Tumors in MicePharmaceutical name: Radix Tripterygii Wilfordii Properties: bitter, acrid, cool Channels entered: Liver Safety index: toxicSignificantly lower tumor weights and volumes（ Molecules 2011, 16,The Main Anticancer Bullets of the Chinese Medicinal Herb,Thunder God Vine Zi Liu 1, Liang Ma 1,2 and Guang-Biao Zhou . ）Lei gong teng relieves pain and reducesswelling in patients who have swollen jointsand difficulty moving. It can be used alone orwith other antirheumatic herbs.“Extracts of this medicinal plant have been used to treata whole host of conditions and have been highly lauded for anti-inflammatory, immunosuppressive, contraceptive and antitumor activities,” says Jun O.Liu, Ph.D., a professor of pharmacology and molecular sciences at Johns Hopkins.
15 Therapy integrating TCM may increase tumor radio-chemo sensitivity, reduce side effects of chemo, prevent metastasis of cancers, and prolong patient survival rates。Specific efficacy of herbs:(1)Herbs that invigorate blood may improve the circulation to the outside surface of cancers, increasing the effect of chemotherapy.Dan Shen (Radix Salviae Miltiorrhizae)(2) may significantly increase the anticancer actions of cyclophosphamide.Jiang Huang (Rhizoma Curcumae Longae), and San Qi(Panax notoginseng)(3) may increase the cancer’s susceptibility to radiotherapy.Gui Zhi Fu Ling Wan(Cinnamon Twig and Poria FormulaT25)
16 (2)Herbs that nourish Yin and clear heat may treat and even prevent pneumonia caused by radiation. Sha Shen, Tian Mrn Dong, Yu ZhuSha Shen Mai Men Dong Tang(Glehnia and Ophiopogonis Formula T163)(3)Herbs that clear heat and cool blood may treat and even prevent cystitis and prostititis caused by radiation.Bai Hua She She Cao, Ban Zhi Lian, Qi Ye Yi Zhi Hua, Shan Tou Gen, Tu Fu Ling, and so on.Jin Huang San(Golden Yellow powder) prevents and cures burning of radiotherapy.
17 (4)Herbs that tonify kidney, strengthen spleen, tonify Qi and blood may prevent decrease of immune function and WBC caused by chemotherapy.Dang Gui, Shu Di Huang, Huang QiGui Pi Tang(Restore the Spleen Formula T65),Bu Zhong Yi Qi Tang(Tonify the Middle and Augment the Qi Formula T41),Liu Wei Di Huang Wan(Rehmannia Six Formula Softgel K001)(5)Herbs that regulate stomach and strengthen spleen can treat and may prevent nausea and vomiting caused by chemotherapy(1).Dang Shen, Fu Ling, Bai Zhu, Bai Bian Dou, Yi Yi RenLiu Jun Zi Tang(Six-Gentleman Formula H43)
18 3.TCM Inhibiting Cancer in Slow but Long Term Improvement There are Chinese herbs that have been proven, in research studies, to effectively inhibit cancers. Bai Hua She She Cao (Herba Hedyoyidis Diffusae) has shown an inhibitory effect in vitro on liver cancer cells. A 57.4% inhibitor effect was shown against sarcoma-180 in mice. With applications of concentration of Teng Li Gen(Actinidia arg-uta Planch)(4) over 45 and 60 days, the survival rate of the mice was respectively 75% and 66.9%.。After injecting the same cancer cells into the mice that had stopped the herb treatment, only two of the 25 mice had cancer and, after 25 days, all of them were surviving. All of the 25 mice in the control group that had not been given herb treatment were dead. This means that the herb may increase the body’s defense against cancer. Numerous studies have shown similar results. In additional clinical trials, Chinese acupuncture and Chinese herbs for cancers have shown a mild positive effect. Long term treatment is needed and the longer the treatment, the more effective.
19 4.TCM benefiting various functions of the whole body Chinese medicine not only benefits immune function but also positively affects the function of nerve, endocrine, hematopoiesis, digestion and metabolism. By stimulating the hematopoetic function of the bone marrow, herbs that strengthen spleen and kidney, such as Gui Pi Tang(5), Liu Wei Di Huang Wan (6), may promote the function of phagocytes, build the function of T cells, increase the WBC and prevent the decrease of WBC caused by chemotherapy. Yin Yang Huo (Herba Epimedii), Huang Qi (Radix Astragali Membranaceus)(7) may stimulate the function of superoxide dismutase (SOD), and reduce free radical damage, lowering the incidence of cancers by prevention of halmatogenesis of normal cells and preventing normal cells turning malignant(8).
20 5. TCM has Fewer and milder side effects Most of the TCM therapies that treat malignancy have far fewer and much milder side effects than those of Western treatment. Acupuncture and herbs treat illness individually, depending on each patient’s exact manifestations and signs. With this individualized combination of TCM treatments, the therapeutic effect is significantly increased and side effects are prevented. No research has yet proven that acupuncture has obvious side effects, though it may occasionally cause mild bruising or minor pain at needle sites. No research in herbal pharmacology has found acute or chronic toxic effects due to the use of Chinese herbs that tonify patient’s vital Qi.
21 6. TCM Improving symptoms and quality of life TCM effectively improves patients’ symptoms, and reduces suffering. With acupuncture or Chinese herbs for strengthening the spleen and stomach, patients’ digestive manifestations such as poor appetite, abdominal bloating, and diarrhea may be improved. With acupuncture or Chinese herbs for strengthening the Qi and blood, patients’ anemia manifestations, such as tiredness, dizziness, and palpitations, are improved. With acupuncture, Chinese herbs or Qigong for strengthening the constitution, patients’ mental attitudes are significantly enhanced, including their perception of and ability to handle pain. Other symptoms, such as chronic pain, low-grade fever, cough, and chest distress also may be relieved with acupuncture and Chinese herbs.
22 (7)TCM Lows incidence of relapse TCM treatment for tumors is different in its mechanism from other therapy. TCM is not aimed at directly killing malignant cells or treating symptoms, but, instead, harmonizes the function of internal organs, stabilizes the internal environment at its better condition, and enhances patients’ natural ability to eliminate malignant cells. There is extensive research that has shown that patients have a much lower incidence of relapse after being healed by TCM.
23 8.The experience of herbs that integrated the differentiation of disease and herbal guide for common cancers.(1)Lung cancer: Shan Dou Gen, Qi Ye Yi Zhi Hua, Bai Ying, Shan Chi Gu, Mao Zhao Cao, Yu Xing Cao, Lu Feng Fang, Zhe bei Mu, Gua Lou, Mai Men Dong, Bai He(2) Nasopharyngeal cancer: Shi Shang Bai, Shan Dou Gen, Ban Zhi Lian, Bai Ying, Yu Xing Cao, Wu Gong, Lu Feng Fang, She Gan, Cang Er Zi(3) Esophageal cancer: Shan Dou Gen, Zhong Jie Feng, Wu Gong, Wei Ling Xian, E Zhu, Xuan Fu Hua, Dai Zhe Shi(4)Stomach cancer: Bai Hua She She Cao, Zhong Jie Feng, Teng Li Gen,Zhe Bei Mu, Wu Zhei Gu(5)Intestinal cancer: Bai Hua She She Cao, Ban Zhi lian, Bai Ying,Zhong Jie Feng, Teng Li gen, Hong Teng, Bai Jiang Cao, Ku Shen,Yi Yi Ren(6)Liver cancer: Ban Zhi Lian, Qi Ye Yi Zhi Hua, Bai Ying, zhong Jie Feng, Teng Li gen, Hu Zhang, Chuan Shan jia, Bie Jia, Wu Gong, Chan Chu, E Zhu
24 (7) Pancreatic Cancer: Zhong Jie Feng, Shi Jian Chuan, Bai Ying, Teng Li Gen, Yin Chen, Jin Qian, Cao, Ban Zhi Lian, Yu Jin, Yi Yi Ren (8)Brain Cancer: Quan Xie, Wu Gong, Jiang Can, Tu Fu Ling, Qi Ye Yi Zhi Hua, Tian Nan Xing, Ban Xia, Xia Ku Cao, Chuan Xiong (9) Leukemia: Qing Dai(Indigofera tintcora L), Xiong Huang, Bai Jiang Cao, Qi Ye Yi Zhi Hua, Zhong Jie Hua, Bai Hua she she cao, Zi Cao, Shui Niu Jiao (10)Malignant lymphoma: Xia Ku Cao, Mao Zhao Cao, Shan Chi Gu, Qi Ye Yi Zhi Hua, Huang Yao Zi, Yi Yi Ren, Zhe Bei Mu, E Zhu, Wu Gong, Chuan Shan Jia, Zhao Jia Ci (11)Breast Cancer: Shan Ci Gu, Pu Gong Ying, Mao Zhao Cao, Gua Lou, Zhe Bei Mu, Xia Ku Cao, E Zhu, Pu Gong ying, Qing Pi, Tian Men Dong (12)Uterine cancer: Tu Fu Ling, Bai Ying, Long Kui, Bai Hua She She Cao, Ban Zhi Lian, Yi Yi Ren, E Zhu (13)Ovarian cancer: Bai Hua She She Cao, Ban Zhi lian, Long Kui, Bai Ying, Tu Fu Ling, Yi Yi Ren, Shui Zhi, E Zhu (14)Thyroid cancer: Huang Yao zi, Shan Ci Gu, Hai Zao, Kun Bu, Xia Ku Cao, Zhe Bei Mu, E Zhu, Mu Li, Wang Bu Liu Xing (15)Bone cancer: Bu Gu Zhi, Gu Shui Bu, Zhong Jie Fneg, Qi Ye Yi Zhi Hua, Bai Ying, Ban Zhi Lian, Lu Feng Fang, Quan Xue, Wu Gong, E Zhu (16)Skin Cancer: Xiong Huan, Tu Fu Ling, Ku shen, Bai Xian Pi, Ya Dan Zi, Yi Yi Ren.
25 (16)Acupuncture for cancers: Ai Gen1 (Root of Cancer, (9) ): on the inferior aspect of the foot at the bottom, inferior margin of the 1st metatarsus, one unit behind the joint of the big toe. Indications: Esophageal cancer, stomach cancer, liver cancer, lymphatic metastases, chronic myeloid leukemia Ai Gen 2: Esophageal cancer, rectum cancer, cervical Cancer, lymphatic metastases
26 Ai Gen 3: Indications: Liver cancer, nasopharyngeal cancer, breast cancer Lu Di San Zen(3 needles of base of Skull) Tumors, masses and diseases of brain, especial the masses near pituitary.
27 Case: 47 female, 4/24/2012. Biopsy diagnosed: Invasive ductal carcinoma, intermediate nuclear grade. She had a mastectomy at 7/12/2012. she has pain of the left breast and arm. Pale purple tongue, slippery and wiry pulse. 7/19/2012. Tao Ren9g, Hong Hua6g, Huang Qi15g, San Qi 6g, Ren Dong Teng15g, Fu Shen9g, Bai Tou weng9g, Chi Shao9g, Niu Xi6g, Mu Dan Pi9g. Points: Si Shen Chong, Yintang, PC6, 4gates, abd. 9needles, Sp9, St36, Sp6 8/8/2012 She is tired, anxiety, very pale tongue, thin white coating, wiry pulse at left and deep weak pulse at right. Huang Qi12g, Dang Gui6g, Fu Shen9g, Dang Shen9g, Niu Xi6g, Bai Zhu6g, Du Zhong6g Points are same as upper. 8/22/2012 She is going to be treated by chemotherapy in one week(Taxus). Her WBC 7.8,RBC 4.14, Hbg12.1, Plt 291, neutrophill percent 66, neutrophill absolute count lymphocyte percent 23.4%(L), eosinophil percent 0.8%, immature granulocytes percent 0.4%, IMM granulocyte absolute count 0.03(H) Pale tongue with think white coating. Wiry pulse at left and weak pulse at right.
28 Mu Xiang3g Sha Ren6 Dang Shen9g Fu Ling9g Bai Zhu6g Chen Pi6g Yi Yi Ren9g Shan Zha9g Bo He3 Points: St36, 9needles of abd. Liv13, 4gates, Yintang, St36, Sp6 8/27/2012 BP130/80, She had chemo 4 days ago. Today, she starts loose BM, 8times/day, tired, poor sleep, anxiety. Pale tongue with white coating, slippery pulse at left and weak at right. Sha Ren6g, Dang shen9g, Fu Shen9g Bai Zhu9g Chen Pi6g Chai Hu6g Shan Zha6g Da Zao3g Bo He3g Wu Wei Zi6g Points: St36, 9 needles of abd. Liv13, 4gates, Yintang, St36, Sp6 , Sp9, Sp4, PC6
29 9/5/2012 Her BM was 1 time/day, after the last treatment two days later. Her appetite is good. She did her second chemo. Pale tongue with thin coating. Wiry and slight rapid pulse. Her blood count of 8/31 is: WBC5.8, RBC4.02, Hgb11.6(L), Plt 291. neutrophill percent 74.8%(H), neutrophill absolute count lymphocyte percent 17.2%(L), eosinophil percent 0.7%, immature granulocytes percent 0.9%(H), IMM granulocyte absolute count 0.05(H) St36, 9 needles of abd. Liv13, 4gates, Yintang, St36, Sp6 , Sp9, Sp4, PC6 Huang Qi 12g Dang Shen6g, Fu Shen6g, Bai Zhu9g E Jiao6g, Suan Zao Ren9g Sang Shen9g Bu Gu Zhi9g Huang Jing9g Gu Shui Bu6g 9/12/2012 She feels tired, slight hair lost. Her blood count of 9/7 is: WBC3.2(L), RBC 3.88(L), Hgb11.4(L), Plt 318, neutrophill percent 52.8, neutrophill absolute count lymphocyte percent 35.2, eosinophil percent 1.2%, immature granulocytes percent 0.3%, IMM granulocyte absolute count Huang Jing9g Gu Shui Bu6g (Zhi)Gan Cao6g
30 9/21/2012 Her blood count of 9/21 is: WBC4. 7, RBC4. 1, Hgb11 9/21/2012 Her blood count of 9/21 is: WBC4.7, RBC4.1, Hgb11.5(L), Plt 357, neutrophill percent 55.8, neutrophill absolute count lymphocyte percent 31.3, eosinophil percent 0.9%, immature granulocytes percent 0.6%(H), IMM granulocyte absolute count Huang Qi 12g Dang Shen6g, Fu Shen6g, Bai Zhu9g E Jiao6g, Suan Zao Ren9g Sang Shen9g Bu Gu Zhi9g Huang Jing9g Gu Shui Bu6g (Zhi)Gan Cao6g St36, 9 needles of abd. Liv13, 4gates, Yintang, St36, Sp6 , Sp9, Sp4, PC6, GB39 9/28/2012 Blood count: WBC4.5, RBC3.81, Hgb11.1(L), Plt 290, neutrophill percent 62.3, neutrophill absolute count 2.8. lymphocyte percent 27.5, immature granulocytes percent 1.1(H) She also has cough. Add (Chuan) Bei Mu6g.
32 11/12 She is going to chemo(5-Fu,cytoxan, ) in a few days 11/12 She is going to chemo(5-Fu,cytoxan, ) in a few days. In order to prevent digestive side effects of chemo, use the following herbs. Mu Xiang6g Sha Ren6g Dang Shen6g Chen Pi6g Fu Ling9g Bai Zhu9g Dang Gui6g E Jaio9g Fu Xiao Mai9g Suan Zao Ren9g Huang Qi12g St36, 9 needles of abd., 4gates, Yintang, Sp6, Sp4, PC6 11/16 Blood count: WBC4.5, RBC3.89, Hgb11.3, Plt 339 She doesn’t have nausea, vomiting and poor appetite.
33 A cancer patient is treated by machine with herbs in a hospital
34 References:1. Chen, JK. Chinese Medical Herbology and Phamacology. Portland2. Chang LC, Wu CL, Liu CW, et al. Preparation, characterization and cytotoxicity evaluation of tanshinone IIA nanoemulsions. J Biomed Nanotechnol Aug;7(4):3. Yan Z, Zhu ZL, Wang HQ, et al. Pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from Panax notoginseng, in healthy volunteers and patients with advanced solid tumors. Acta Pharmacol Sin Nov;31(11):4.Zhong ZG, Zhong WY, Zhang FF, et al. Research on the Extracts of Chinese and Vietnamese Teng Li Gen Anticancers in Vitro. Jurnal of Matriel Medica. 2005,28(3)：215－ Han ZY. Clinical observation on Guipi decoction on cancer chemotherapy with anemia and increase quality of life. Clinical Journal of Chinese Medicine.2010,02,18.6. Li PW. Clinical Observation on Inhibitory Effect of Liu Wei Di Huang Pill on Serious Esophageal Epithelium Proliferation, Report of 211 Cases. Chinese Journal of Integrated Traditional and Western Medicine. 2007, 057. Taixiang W, Munro AJ, Guanjian L. Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane Database Syst Rev Jan 25;(1):CD8. Johnston MF, Ortiz Sanchez E, Vujanovic NL, et al. Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells. Evid Based Complement Alternat Med. 2011:9.Hua Jinkai. Extra Acupuncture points. Nam Tung Stationery & Publishing CO. Hong Kong.