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Isospora suis Infection in Nursing Pigs Peter Moisan North Carolina Department of Agriculture Presented at SEVPAC 2008 – Permission granted for use on.

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Presentation on theme: "Isospora suis Infection in Nursing Pigs Peter Moisan North Carolina Department of Agriculture Presented at SEVPAC 2008 – Permission granted for use on."— Presentation transcript:

1 Isospora suis Infection in Nursing Pigs Peter Moisan North Carolina Department of Agriculture Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

2 Case History Herd of several hundred sows. Farrow-to-finish operation. Diarrhea in preweaned piglets for many months. Various diagnoses in the past. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

3 Case History (cont.) The current outbreak involved day- old piglets. Morbidity 50% and mortality 10-20%. Territoriality did not change (pigs were not very weakened by diarrhea). Survivors were stunted and underweight. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

4 Gross Lesion Regionally extensive necrotizing enteritis. Often with pseudomembrane. Pasty tan (butterscotch pudding-like) feces. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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7 Microscopic Lesion Acute, severe, necrotizing, regionally extensive enteritis with villous attenuation, regeneration, and intracytoplasmic coccidia. All coccidian life stages were represented. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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12 Life Cycle of Isospora suis Oocysts are shed in the feces and sporulate in a few days. Sporulated oocysts are ingested. Oocysts excyst and release sporozoites that infect the small intestinal enterocytes. Merozoites are produced by endodyogeny of the sporozoites and produce several generations that infect additional enterocytes. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

13 Life Cycle (cont.) Merozoites go through merogony to form gamonts. Microgametocytes and macrogametocytes fuse by gametogeny to form new non- sporulated oocysts. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

14 Significance of Piglet Coccidiosis This is a syndrome that occurs “between other scours syndromes”. Pigs are too young for some scours agents and too old for others. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

15 Significance (cont.) Pigs develop coccidiosis at days of age. If younger, we are more likely looking at: Clostridium difficile. Clostridium perfringens Type A or Type C. Colibacillosis. TGE. Rotavirus. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

16 Significance (cont.) Pigs develop coccidiosis at days of age. If older (post-weaning), we are more likely looking at: Salmonella. Brachyspira. Lawsonia. Rotavirus. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

17 Significant Diagnostic Tips Pasty stools. Age between other major diarrhea syndromes. Villous attenuation. In severely affected villi, the coccidia are hard to locate. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

18 Significant Diagnostic Tips (cont.) When very few coccidia are present, we need to consider other causes of villous atrophy, such as TGE, rotavirus, and Clostridium perfringens Type A or Type C. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

19 Acknowledgements Histology Technician Mary Horne and the Histology Staff at Rollins Laboratory. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


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