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Intranasal Light Therapy for brain stimulation

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Presentation on theme: "Intranasal Light Therapy for brain stimulation"— Presentation transcript:

1 Intranasal Light Therapy for brain stimulation
The Potential of Intranasal Light Therapy for brain stimulation By: Lew Lim Presented at NAALT 2013 January 2013 Copyright: Lew Lim

2 The mother: intravenous irradiation
Parameters are based on Blood irradiation January 2013 Copyright: Lew Lim

3 Why the nose Vascular concentration January 2013 Copyright: Lew Lim

4 Design opportunities Non-invasive blood irradiation
Small and convenient Low cost Idiot proof January 2013 Copyright: Lew Lim

5 You can also run a truck over it!
January 2013 Copyright: Lew Lim

6 It stimulates systemic homeostasis
…and the body attempts to heal anything unprogrammed. January 2013 Copyright: Lew Lim

7 When something profound works ….
January 2013 Copyright: Lew Lim

8 Present parameters LED model: 633 nM, CW 8 mW, 25 min 12 J/cm²
Laser model: 655mW, CW 4.8 mW, 25 min 7.2 J/cm² January 2013 Copyright: Lew Lim

9 Re-emphasis from blood irradiation to brain stimulation
January 2013 Copyright: Lew Lim

10 Deep brain stimulation for Parkinson’s
- Example of effective alternative method It’s about stimulation January 2013 Copyright: Lew Lim

11 History of neurological evidence
With present Intranasal Low Level Laser Therapy parameters Facial pain, 1998 Intractable headache, 1998 Cerebral thrombosis, 1999 Parkinson’s disease, 1999 Alzheimer’s disease, 1999 Mild cognitive impairment, 2000 Insomnia, 2001 Post-stroke conditions, 2003 Migraine, 2003 Traumatic brain injury, 2003 Schizophrenia, 2000 Vascular dementia, 2005 Cerebral palsy, 2007 Can we still improve? January 2013 Copyright: Lew Lim

12 Improvement in brain blood flow
Before After Net increase Stroke patient. 650 nm, 4 mW, 30 min/day, 7.2 J/cm²/day, 10 days Source: Single photon emission computed photometry by Prof Xiao XC, 2005 January 2013 Copyright: Lew Lim

13 Brain Cell Healing In vitro post-oxidative stress. 670nm, 3 mW, 20 sec/day, 5 days Source: Giuliani et al. Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Com Alt Med 2009, 9:8. January 2013 Copyright: Lew Lim

14 Picture source: OpimMeadow. Flickr
Transcranial Limbic system Intranasal: Path of low resistance to mid-brain Picture source: OpimMeadow. Flickr January 2013 Copyright: Lew Lim

15 Thin ethmoid bone plate is thin
January 2013 Copyright: Lew Lim

16 Opportunity for new parameters
January 2013 Copyright: Lew Lim

17 Optical penetration depth
630nm 660nm 810nm Source: Barolet D. Light-emitting Diodes (LED) in Dermatology. 2008 January 2013 Copyright: Lew Lim

18 Effect of 10 hz pulsed mode
Area under curve Neurological Severity Score Ando et al. Comparison of Therapeutic Effects between Pulsed and Continuous Wave 810-nm Wavelength Laser Irradiation for Traumatic Brain Injury in Mice. Plos One. Oct 2011 January 2013 Copyright: Lew Lim

19 Deeper tissue travel may help with proximity to:
Substantia nigra for Parkinson’s Subventricular zone for neurogenesis Hypothalamus for homeostasis 10 Hz helps: Greater neural response Seratonin for depression Alpha state 8-12 Hz entrainment for an “ordered state” Hippocampal theta state 5-10 Hz: resonates with hippocampus for behavioral inhibition, attention, spatial memory Large beam footprint for: Systemic response Vascular dementia and Alzheimer’s January 2013 Copyright: Lew Lim

20 The “brain-effective” model
810 nm 10 mW Pulsed: 10 Hz 50% duty cycle 25 min 7.5 J/cm² post-duty cycle January 2013 Copyright: Lew Lim

21 Initial reports Enhanced neural response:
Improved cognitive performance Enhanced post-stroke conditions Parkinson’s disease condition better But more clinical investigations needed January 2013 Copyright: Lew Lim

22 Full paper available: http://www.mediclights.com/brain-potential
Presentation By: Lew Lim January 2013 Copyright: Lew Lim


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