Presentation on theme: "The Potential of Intranasal Light Therapy for brain stimulation By: Lew Lim January 20131Copyright: Lew Lim Presented at NAALT 2013."— Presentation transcript:
The Potential of Intranasal Light Therapy for brain stimulation By: Lew Lim January 20131Copyright: Lew Lim Presented at NAALT 2013
The mother: intravenous irradiation January 2013Copyright: Lew Lim2 Blood irradiation Parameters are based on
Why the nose January 2013Copyright: Lew Lim3 Vascular concentration
January 2013Copyright: Lew Lim4 Non-invasive blood irradiation Small and convenient Low cost Idiot proof Design opportunities
January 2013Copyright: Lew Lim5 You can also run a truck over it!
It stimulates systemic homeostasis January 2013Copyright: Lew Lim6 …and the body attempts to heal anything unprogrammed.
January 2013Copyright: Lew Lim7 When something profound works ….
Present parameters January 2013Copyright: Lew Lim8 LED model: 633 nM, CW 8 mW, 25 min 12 J/cm² Laser model: 655mW, CW 4.8 mW, 25 min 7.2 J/cm²
January 2013Copyright: Lew Lim9 Re-emphasis from blood irradiation to brain stimulation
January 2013Copyright: Lew Lim10 Deep brain stimulation for Parkinson’s - Example of effective alternative method It’s about stimulation
History of neurological evidence January 2013Copyright: Lew Lim11 Facial pain, 1998 Intractable headache, 1998 Cerebral thrombosis, 1999 Parkinson’s disease, 1999 Alzheimer’s disease, 1999 Mild cognitive impairment, 2000 Insomnia, 2001 Post-stroke conditions, 2003 Migraine, 2003 Traumatic brain injury, 2003 Schizophrenia, 2000 Vascular dementia, 2005 Cerebral palsy, 2007 With present Intranasal Low Level Laser Therapy parameters Can we still improve?
January 2013Copyright: Lew Lim12 Before After Net increase Improvement in brain blood flow Source: Single photon emission computed photometry by Prof Xiao XC, 2005 Stroke patient. 650 nm, 4 mW, 30 min/day, 7.2 J/cm²/day, 10 days
January 2013Copyright: Lew Lim13 Brain Cell Healing Source: Giuliani et al. Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Com Alt Med 2009, 9:8. In vitro post-oxidative stress. 670nm, 3 mW, 20 sec/day, 5 days
January 2013Copyright: Lew Lim14 Picture source: OpimMeadow. Flickr Intranasal: Path of low resistance to mid-brain Limbic system Transcranial
January 2013Copyright: Lew Lim15 Thin ethmoid bone plate is thin
January 2013Copyright: Lew Lim16 Opportunity for new parameters
January 2013Copyright: Lew Lim17 Source: Barolet D. Light-emitting Diodes (LED) in Dermatology Optical penetration depth 810nm 630nm 660nm
January 2013Copyright: Lew Lim18 Effect of 10 hz pulsed mode Ando et al. Comparison of Therapeutic Effects between Pulsed and Continuous Wave 810-nm Wavelength Laser Irradiation for Traumatic Brain Injury in Mice. Plos One. Oct 2011 Neurological Severity Score Area under curve
January 2013Copyright: Lew Lim19 Deeper tissue travel may help with proximity to: Substantia nigra for Parkinson’s Subventricular zone for neurogenesis Hypothalamus for homeostasis 10 Hz helps: Greater neural response Seratonin for depression Alpha state 8-12 Hz entrainment for an “ordered state” Hippocampal theta state 5-10 Hz: resonates with hippocampus for behavioral inhibition, attention, spatial memory Large beam footprint for: Systemic response Vascular dementia and Alzheimer’s
The “brain-effective” model January 2013Copyright: Lew Lim nm 10 mW Pulsed: 10 Hz 50% duty cycle 25 min 7.5 J/cm² post-duty cycle
Initial reports January 2013Copyright: Lew Lim21 Enhanced neural response: Improved cognitive performance Enhanced post-stroke conditions Parkinson’s disease condition better But more clinical investigations needed
January 2013Copyright: Lew Lim22 Presentation By: Lew Lim Full paper available: