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Germline Modification and Mitochondrial Replacement John H. Evans Department of Sociology, University of California, San Diego.

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Presentation on theme: "Germline Modification and Mitochondrial Replacement John H. Evans Department of Sociology, University of California, San Diego."— Presentation transcript:

1 Germline Modification and Mitochondrial Replacement John H. Evans Department of Sociology, University of California, San Diego

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4 Germline HGE Purpose = eliminate disease in the species (Genetic Load), Improve the Qualities of the Species (like Intelligence) Exemplar Proponents: Julian Huxley, Hermann Muller, Joseph Fletcher Exemplar Opponents: Paul Ramsey, Leon Kass

5 Somatic HGEGermline HGE Purpose = Restore normal state of health (e.g. avoid/heal cystic fibrosis) Cell 1Cell 2 Purpose = Enhance non-disease traits (e.g. increase intelligence) Cell 3Cell 4 Advocates: Bernard Davis (1970), Paul Ramsey (1971), W. French Anderson (1971), later the Recombinant DNA Advisory Committee

6 Somatic HGEGermline HGE Purpose = Restore normal state of health (e.g. avoid/heal cystic fibrosis) Cell 1Cell 2 Purpose = Enhance non-disease traits (e.g. increase intelligence) Cell 3Cell 4 Advocates: Bernard Davis (1970), Paul Ramsey (1971), W. French Anderson (1971), later the Recombinant DNA Advisory Committee

7 Somatic HGEGermline HGE Purpose = Restore normal state of health (e.g. avoid/heal cystic fibrosis) Cell 1Cell 2 Purpose = Enhance non-disease traits (e.g. increase intelligence) Cell 3Cell 4 Advocates: Bernard Davis (1970), Paul Ramsey (1971), W. French Anderson (1971), later the Recombinant DNA Advisory Committee

8 Advocates: Nuffield Council (p.65) Somatic HGEGermline mtDNA Germline nDNA Purpose = Restore normal state of health (e.g. avoid/heal cystic fibrosis) Cell 1Cell 2aCell 2b Purpose = Enhance non-disease traits (e.g. increase intelligence) Cell 3Cell 4aCell 4b

9 Somatic HGEGermline HGE Purpose = Restore normal state of health(e.g. avoid/heal cystic fibrosis) Cell 1Cell 2 Purpose = Enhance non-disease traits (e.g. increase intelligence) Cell 3Cell 4 Advocates: Bernard Davis (1970), Paul Ramsey (1971), W. French Anderson (1971), later the Recombinant DNA Advisory Committee

10 Somatic HGEGermline HGE Purpose = Restore normal state of health Purpose = Relieve Suffering from Disease Cell 1Cell 2 Purpose = Enhance non-disease traits Cell 3Cell 4

11 Somatic HGEGermline HGE Resulting Genome Was Possible “Naturally” Resulting Genome Was Not Possible “Naturally.”


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