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به نام خدا.

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Presentation on theme: "به نام خدا."— Presentation transcript:

1 به نام خدا

2 معرفی داروهای جدید و قدیم در زنان
M.D. O.B. & Gyn. Shahin Golshah

3

4 Estrone Estrodiol Estriol

5 Estrogen

6 Progestrone Process

7 Progestrone Process

8 Drospirenone

9 Contraceptive Patch Hormones embedded in adhesive layer of the patch
Composition: EE/norelgestromin Applied: abdomen, buttocks, arm Use 3wks plus 1 patch free wk Efficacy: 5 preg/5,240 cycles Mech, indications & side effects: similar to OCPs Not effective women >180 lbs This is one of the newer contraceptive delivery systems. Instead of taking a pill orally, the hormones are delivered transdermally via a patch. The contraceptive patch is very effective. The mechanism, indications for use and side effect profiles are similar to oral contraceptive pill. Contains ethinlyl estradiol and norelgestromin. Not an effective method of contraception for women > 180 lbs. • Launched: June 2002 OB/GYN News, 2002 6-

10 Norelgestromin

11 Cyproterone Compound (Anti Androgenic Progestin)

12 Combination Oral Contraceptive Pills
Treatment Regimen 21 hormone days 7 hormone free days This is an example of a monophasic combined oral contraceptive pill. Each pill contains both an estrogen and progestin and it is administered for 21 days. The amount of estrogen and progestin in each pill does not vary from pill to pill. The last seven days are “hormone free.” Because of the sharp drop in hormone at the end of 21 days, the woman will experience withdrawal bleeding or menstrual period. Oral contraceptive pills were designed to mimic a woman’s 28 day menstrual cycle. In fact contraceptive pills could have been designed in such a way that a woman would have a period every three or four months without experiencing any ill effects. This could be accomplished by skipping the pill free day. In some cases women having significant problems with their menstrual periods can be placed on “continuous” oral contraceptive pills, skip the hormone free day and never have a menstrual period without any ill effects. By tradition, most contraceptive pills, are designed so that the woman has a period every month. 6-

13 Oral Contraceptives Available in the US

14 Oral Contraceptives Available in the US

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17 Estrogen Progestin 30 Levonorgestrel 0.15 50 0.25 Drospirenone 3
Product Name Manufacurer Type Dose µg/days Dose mg/days Ovustop-L ایران هورمون E.E. 30 Levonorgestrel 0.15 Contraceptive HD 50 0.25 Contrasmine Drospirenone 3 Desoptive Desogestrel Rokin ابوریحان Cyproteron Compound 35 Cyproterone Acetate 2 Dian Bayer Cyrpoterone Acetate Marvelon Organon Yaz 20 Yasmin

18 Diphereline 3.75mg S.R. 1. NAME OF THE MEDICINAL PRODUCT
Diphereline 3,75mg S.R. powder and solvent for suspension for injection, sustained release form. INN: triptorelin 2. QUALITATIVE AND QUANTITATIVE COMPOSITION. PHARMACEUTICAL FORM. Powder (triptorelin, D,L lactide-coglycolide polymer, mannitol, Carmellose sodium, Polysorbate ) and solvent (water, mannitol) for suspension for injection (i.m.), sustained release form.

19 3. CLINICAL PARTICULARS 3.1. Therapeutic indications Prostate cancer. Treatment of the prostate cancer with metastases. Patients who have not previously received hormone therapy respond better to Diphereline. Precocious puberty ( before 8 years in girls and 10 years in boys ). Genital and extra genital endometriosis (stage I to IV ) Female infertility Supplementary treatment in combination with gonadotrophin to induce ovulation with a view to in vitro fertilisation and embryo transfer (I.V.F.E.T.). Myoma

20 - from the outset , one i. m. injection of Diphereline 3. 75 mg S. R
- from the outset , one i.m. injection of Diphereline 3.75 mg S.R., repeated every 28 days. Precocious puberty: Children weighing more than 20 kg Endometriosis The treatment must be started in the first five days of menstrual cycle.

21 One i. m. injection of Diphereline 3. 75 mg S. R
One i.m. injection of Diphereline 3.75 mg S.R. on the second day of the cycle. Gonadotropins should be started after the pituitary desensitisation ( plasma estrogens less than 50 pg/ml ), generally 15 days after injection of Diphereline. 3.3. Contraindications : Should never be used during pregnancy.

22 Female infertility Warnings and precautions: the follicular retrieval may increase markedly in some predisposed patients and particularly in those with polycystic ovarian disease. 4. PHARMACOLOGICAL PROPERTIES Triptorelin is a synthetic decapeptide analogue of natural GnRH

23 با تشکر از توجه شما


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