5 Fresh Frozen Plasma (FFP) 1Fresh Frozen Plasma (FFP)Prepared from whole blood donation and frozen within 6 – 8 hours .It is stored at – 18o c or colder for up to 12 months.It contains: 91% water – 7% protein – 2% carbohydrate.
6 Fresh Frozen Plasma (FFP) 1Fresh Frozen Plasma (FFP)IndicationsTo treat prolonged PT or PTTVitamin K deficiency and liver diseaseDilutional coagulopathyProtein S, Protein C or Antithronbin deficiency.
7 Fresh Frozen Plasma (FFP) 1Fresh Frozen Plasma (FFP)ThawingIt should be thawed at temperature 30-37oc in a water bath.The unit should be wrapped in a plastic bag.Thawed FFP should be transfused immediately or within 12 hrs or stored between 1-6oc for no more than 12 hours.It should not be refrozen.
8 Fresh Frozen Plasma (FFP) 1Fresh Frozen Plasma (FFP)AdministrationThe same ABO as the protein.Given via a filter over 1 – 1.5 hours.
9 CRYOPRECIPITATE 2 Obtained from FFP and concentrated to 10 - 20 ml. It contains F VIII, (80 – 120 Units), v WF, 250 mg fibrinogen, 20 – 30% of factor XIII & fibronectin.
10 CRYOPRECIPITATE 2 Indications Factor VIII deficiency (Haemophilia A). Type II VW disease.Type I VW disease not responding to DDAVP.Factor XIII deficiency.Congenital fibrinogen abnormality.
11 CRYOPRECIPITATE 2 Indications When fibrinogen is ≤ 100 mg. Control of bleeding in uremic or hepatic patients.For preparation of fibrin glue: Topical use in orphopedic, ENT, dental, cardiac or neurological procedures.Reversal of warfarin overdose.
12 CRYOPRECIPITATE 2 Thawing It should be thawed at 37 0 c immediately before use and the pack should NOT be refrozen.Fibrinogen dose: 8 – 10 bags supply 2 g fibrinogen.InfusionFilter at rate of 1 – 2 ml/min.
13 2CRYOPRECIPITATECryoprecipirate represents the cryoglobulin fraction of the plasma.It contains F VIII, VWF, fibrinogen, fibronectin and F XIII.It is used primarily for the treatment of Haemophilia A patients.
14 Platelet Concentrates 3Platelet ConcentratesVolume: 50 – 70 ml/unit provide about platelets. Kept at 20 – 22 0 c in a shaker for a maximum of 5 days.Should be infused within 4 hours, administered with filter
15 4Prothrombin ComplexThis component contains prothrombin (F II), factor VII, F IX and factor X.It is lyophylized and virus-inactivated to reduce the risk of transmitting infections.IndicationsHaemophilia B (F IX deficiency).Serious coumarin overdosage together with Vitamin K1Coagulation defects due to fulminant hepatitis or liver insufficiency.
16 5FEIBA AND AUTOPLEXThese are some activated prothrombin complex preparations used for treatment of Haemophilia A patients with inhibitors.These should be given with caution, as overuse may cause thrombosis and DIC.Currently, there are factors IX and F VII concentrates for TR of Haemophilia B.
17 6Fibrin GlueIt is formed by the reaction of cryo (fibrinogen) + thrombin as they are applied topically.AdvantageGood hemostasis in different solid organ bleeding.Prevents post-operative bleeding.Efficient in the presence of coagulation defect and bacterial contamination.
18 Study QuestionMention the indication of cryopercipitate.
19 AssignmentsComplication of blood transfusionمحمد مصطفى محمد