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 Currently around 180,000-230,000 individuals are living with spinal cord injuries throughout the world.  There are limited therapies available for.

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Presentation on theme: " Currently around 180,000-230,000 individuals are living with spinal cord injuries throughout the world.  There are limited therapies available for."— Presentation transcript:

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2  Currently around 180, ,000 individuals are living with spinal cord injuries throughout the world.  There are limited therapies available for SCI patients.  New therapies are being tested Functional Neuromuscular Stimulation Weight bearing treadmill therapy

3  Do treadmill therapy and Functional Neuromuscular Stimulation therapy improve sensory motor control in rats with spinal cord injury?Prediction  Rats receiving FNS therapy and treadmill therapy should have a greater over all recovery and should improve on the horizontal ladder assessment at a faster rate.

4  Rats are used due to similar physiology of SCI  New rats were acclimated for a week, then pre- trained for the following week.  Rats received a high injury level of 170 kdyne.  Rats assessed weekly in conjunction with other behavioral tests › 2D & 3D Kinematics, BBB test Pre-injury 7 DPI14 DPI 21 DPI28 DPI 35 DPI 42 DPI Pre-Training Recovery Animals tested on Ladder once a week for 5 weeks.

5  Rats’ ability to traverse horizontal ladder was tested once a week after initial injury.  Points were awarded for each trial depending on the number of foot faults.  A foot fault is any mistake that the rat makes where their foot falls below the ladder and hits the counter platform underneath.

6 Clip shows rat walking across horizontal ladder. Each time the rat’s foot misses the rung it is counted as a foot fault.

7  The average points decrease drastically between pre and post injury measurements.  FNS therapy rats had a higher average points after 14 DPI than non-therapy and treadmill therapy.  At the end of 42 DPI there was no significant difference between the average points of the three therapies.

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9  Not all animals have results for 42 DPI due to different complications; this could cause the data at day 42 to be skewed.  The similar result for all three therapies could be attributed to the high level of injury the animals received.  This high injury level could inhibit the adequate recovery of the sensory motor skills need for the horizontal ladder.  More experiments are being performed with a lower injury level.

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