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1slide Psoriasis A common scaly and inflammatory skin disorder that is both painful and disabling Thought to be an autoimmune disease with a possible genetic.

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Presentation on theme: "1slide Psoriasis A common scaly and inflammatory skin disorder that is both painful and disabling Thought to be an autoimmune disease with a possible genetic."— Presentation transcript:

1 1slide Psoriasis A common scaly and inflammatory skin disorder that is both painful and disabling Thought to be an autoimmune disease with a possible genetic link The activation of T cells is the key trigger

2 2slide T cells CD4+ T helper cell CD8+ T cell T suppressor cell Memory T cell CD8+ cytotoxic (‘killer’) T cell Thymus Pre T cells

3 3slide Activation Activation of cytotoxic T cells Antigen Cytotoxic T cell Antigen presenting cell T cell receptor Activated T cell IL-6, IL-8 Interferon-  GM-CSF TNF- 

4 4slide Common cytokines Main functionCytokine TNF (alpha and beta) IL-6 IL-8 GM-CSF IFN-  Stimulates accumulation of neutrophils and macrophages at sites of inflammation Stimulates cells to produce proinflammatory cytokines Induces synthesis of CSF by endothelial cells and fibroblasts Affects B-lymphocytes, T-lymphocytes and hybridoma cells Affects cytotoxic T-cells in combination with other factors such as IL-2 and gamma interferon Promotes neutrophil chemotaxis and degranulation Potent species-specific stimulator of bone marrow cells Stimulates precursor cells of granulocytes, macrophages and eosinophils Possesses potent anti-viral activity Has also been shown to stimulate macrophages and natural killer (NK) cells

5 5slide Epidermis Dermis TNF-  activated endothelium Blood vessel Immunological cascade in psoriasis 1. Rolling 2. Activation 3. Arrest/ spreading 4. Migration into skin Cytokines increase keratinocyte proliferation, decrease their maturation and trigger inflammation TNF-  GM-CSF IL-1IL-8 Proinflammatory cytokines magnify effects


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