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Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution.

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Presentation on theme: "Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution."— Presentation transcript:

1 Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution – Non-Commercial 3.0 License: We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The attribution key found at the end of the module provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

2 Histology of Blood and Bone Marrow – Second Look Michael Hortsch, Ph.D. Department of Cell and Developmental Biology University of Michigan © 2010 Michael Hortsch

3 Identify this type of cell found in the blood. Approximately, how many of these cells are normally found per ml of blood ? On average the diameter of these cells is … ?

4 Where are these cell fragments produced ? Identify the small structures encircled by the black stippled lines.

5 Identify this type of leukocyte found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Summarize the most important functions of this cell type ?

6 Identify this type of leukocyte found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Briefly summarize the most important functions of this cell type ?

7 Identify this type of leukocyte found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Briefly summarize the most important functions of this cell type ?

8 Identify this type of cell found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Summarize the most important functions of this cell type ?

9 Identify this type of cell found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Briefly summarize the most important functions of this cell type ?

10 Identify this type of cell found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Briefly summarize the most important functions of this cell type ?

11 Identify this type of cell found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Briefly summarize the most important functions of this cell type ?

12 Identify this type of cell found in the blood. How abundant (in percent) is this cell type in a normal blood leukocyte population ? Briefly summarize the most important functions of this cell type ?

13 Identify the three leukocytes in this image. How many agranulocytes can you identify in this image ?

14 Identify the two leukocytes in this image and briefly outline the physiological processes they are involved in. Image courtesy of A.K. Christensen, University of Michigan

15 The white blood cell in middle is the precursor of at least one of the cells in the periphery. Which of the other cells is/are derived from the cell in the middle ? (Warning! The images are not shown to scale.) PAS & Azure II stain

16 The white blood cell in middle can possibly be the precursor cell of at least one of the cells in the periphery. Which of the other cells is/are derived from this cell ? (Warning! The images are only approximately to scale.) PAS & Azure II stain

17 Identify this cell type

18 Briefly summarize the most important functions of this cell fragment ?

19 Identify this cell type

20

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24 Identify the two leukocytes that are outlined by the dashed lines. These two cells undergo a specific process. Name this process. Endothelial cell

25 What are the spaces called that are indicated by the black arrows and dashed lines ?

26 What are the cellular areas called that are indicated by the white arrows and dashed lines ?

27 Identify the 4 cells marked by the dashed ovals. Where do these cells reside and what is the major product of these cells ?

28 Describe the functional differences between these two images of bone marrow.

29 Slide 3:Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100% Slide 4:Michigan Histology Hematology Lab Normal1 63X.svs Slide 5:Michigan Histology Hematology Lab Normal1 63X.svs 100% Slide 6:Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100% Slide 7:Michigan Histology Hematology Lab Normal1 63X.svs 100% Slide 8:Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100% Slide 9:Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100% Slide 10:Image courtesy of Ryan Brand Slide 11:Image courtesy of A.K. Christensen Slide 12: Image courtesy of Ryan Brand; Plasma cell Michigan virtual slide collection 029-1_HISTO_40X.svs; Macrophage Michigan virtual slide collection 026_HISTO_40X.svs, Mast cell Michigan virtual slide collection 160_HISTO_40X.svs; fat cell Michigan Histology 152_HISTO_40X.svs; Basophil Hematology Lab Normal Smear 86X thick.svs; Neutrophil 029-1_HISTO_40X.svs; Slide 14: Michigan Histology Blood_001.svs Slide 15:Michigan Histology Blood_001.svs platelet Slide 16:Michigan Histology Neutrophil_001.svs Slide 17:Michigan Histology Monocyte_001.svs Slide 18:Michigan Histology Lymphocyte_001.svs Slide 19:Michigan Histology Eosinophil_001.svs Slide 20:Michigan Histology Basophil_001.svs Slide 21:Michigan Histology Blood_001.svs Slide 22:Michigan Histology UCSF083_40X.svs Slide 23:Michigan Histology UCSF083_40X.svs Slide 24:Michigan Histology possibly slide 048_HISTO_40X.svs Slide 25:Michigan Histology 94_HISTO_40X.svs gallbladder wall 22% and 79% Attributions by Slide Slide 13:Image courtesy of Ryan Brand; Plasma cell Michigan virtual slide collection 029-1_HISTO_40X.svs; Macrophage Michigan virtual slide collection 026_HISTO_40X.svs; Michigan virtual slide collection 160_HISTO_40X.svs; Basophil Hematology Lab Normal Smear 86X thick.svs; Neutrophil 029-1_HISTO_40X.svs;

30 Attribution Key for more information see: Use + Share + Adapt Make Your Own Assessment Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation License Creative Commons – Zero Waiver Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (17 USC § 102(b)) *laws in your jurisdiction may differ Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Government: Works that are produced by the U.S. Government. (17 USC § 105) Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (17 USC § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis to determine whether or not your use will be Fair. { Content the copyright holder, author, or law permits you to use, share and adapt. } { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } { Content Open.Michigan has used under a Fair Use determination. }


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