2 HSCT - definition Definition any procedure where hematopoietic stem cells of any donor and any source are given to a recipient with intention of repopulating/replacing the hematopoietic system in total or in part
3 History the radiation protection phenomenon (mid-1950s) Hematopoietic stem cell transplantation in the mousethe radiation protection phenomenon (mid-1950s)Hematopoietic stem cell tranplantation in the dogHematopoietic stem cell tranlsplantation in humanpatients1959–1963 : first allogeneic HSCT in humansbeginning of the Modern Era of HSCT: the end of 1960
4 first succsessful HSCT in treatment of acute leukemias The Nobel Prize, 1990E. Donnall Thomasfirst succsessful HSCT in treatment of acute leukemiasThomas ED, Lochte HL, Lu WC, Ferrebee JW. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N. Engl. J. Med. 1957; 257: 491.
5 Stem cells population of undifferentiated cells which are able to divide for indefinite periodto self renewto generate a functional progeny of highly specialised cells
15 Factors influencing the outcome of HSCT Disease factorsstagePatient - related factorsAgeDonor - related factorsHistopompatibility (HLA)SexViral status (CMV positivity)Peri-transplant factorsConditioningGVHD preventionStem cell source and contentPost-transplant factorsGVHD
16 Complication Allogeneic Autologous Early Early Late Late infection aGVHDbleedingtoxicitygraft failureLatechGVHDrelapsegonadal failuresecondary malignancyAutologousEarlyinfectionbleedingtoxicityLaterelapsegonadal failuresecondary malignacy
20 EBMT Database Disease Patients Procedures Note: Data reporting is incomplete, in particular for the most recent years
21 Number of procedures by year EBMT DatabaseNumber of procedures by yearNote: Data reporting is incomplete, in particular for the most recent years
22 Number of Procedures by Type of Transplant EBMT DatabaseNumber of Procedures by Type of Transplant14000AlloAuto12000100008000600040002000196819721975197819811984198719901993199619992002Note: Data reporting is incomplete, in particular for the most recent years
23 Plasticity and transdifferentiate of stem cells: potential clinical impact in regenerative medicine
Your consent to our cookies if you continue to use this website.