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Prince Henry’s Institute Monash Medical Centre 246 Clayton Road, Clayton, Victoria Contacts: Dr. Morag Young:

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Presentation on theme: "Prince Henry’s Institute Monash Medical Centre 246 Clayton Road, Clayton, Victoria Contacts: Dr. Morag Young:"— Presentation transcript:

1 Prince Henry’s Institute Monash Medical Centre 246 Clayton Road, Clayton, Victoria Contacts: Dr. Morag Young: Prof. Peter Fuller: Steroid Receptor Biology

2 Mineralocorticoid receptors (MR) and Heart Disease Heart disease is a leading cause of death in Australia (40%) MR are a key players in this pathology…but how?! Dr Morag Young Uninephrectomised mouse/rat treated with aldosterone/DOC plus 0.9% saline Cardiac FibrosisHypertension Cardiac Hypertrophy Oxidative Stress NADPH oxidase Inflammation COX-2 Osteopontin Macrophages 8 days 8 weeks We have 3 tissue selective MR knockout mouse strains that we are using to determine the specific role of the MR in heart

3 Mineralocorticoid receptors (MR) and Heart Disease Dr Morag Young Fibrillar collagen Fibroblast VSMC Endothelial cell Cardiac myocyte Artery Macrophage MR-null mice: No effect on DOC-induced monocyte/macrophage recruitment Reduced basal gene expression Cardiac myocyte MR-null mice: No effect on DOC-induced monocyte/macrophage recruitment No effect on inflammatory gene expression Endothelial cell MR-null mice: Reduced DOC-induced macrophage recruitment at 8 days MR

4 Granulosa Cell Tumours (GCT) Comprise 5% of malignant ovarian tumours Molecular analysis of tumour bank and cell lines Tissue selective knockout of IKK signalling in ovaries Our focus has been on: profiles of gene expression: candidates & microarray signalling pathways – constitutive activation expression of ER  coregulatory molecules ERβ-induced genes mutation detection Implications for normal granulosa cells Professor Peter Fuller


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