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Emotional Memory ( The Prefrontal Cortex) & Phineas Gage B9902052 陳 黎 B9902068 曾資斌.

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Presentation on theme: "Emotional Memory ( The Prefrontal Cortex) & Phineas Gage B9902052 陳 黎 B9902068 曾資斌."— Presentation transcript:

1 Emotional Memory ( The Prefrontal Cortex) & Phineas Gage B 陳 黎 B 曾資斌

2 A Gruesome but True Story Phineas P. Gage (1823 –1860) construction foreman left frontal lobe destroyed effects ? "no longer Gage".

3 左前額葉皮 質嚴重損壞 生理機能正常 情緒表現異常 左前額葉與生 理機能無關 左前額葉與情 緒表現相關 How? The Limbic System Before & After

4 Take a Closer Look…… Before After Why?? Prefrontal cortex damaged Emotionally detached impatient erratic

5 The Lymbic System

6 Prefrontal cortex(PFC) Frontal lobe granular electrical stimulation evoke movements Motor cortex Premotor area Prefrontal cortex

7 Function Importance? CEO of the brain Jiminy cricket “It is the tiny voice help you decide what is right and wrong.”

8 When PFC goes wrong… 運作過度 …… 活動低落 …… (lack of dopamine)

9 What happened to Gage? Destroyed Not destroyed

10 PFC & ADHD 意力不足過動障礙症 ( 過動症 ) Attention Deficit Hyperactivity Disorder Why? Dopamine dopa decarboxylase 多巴脫羧酵素

11 Lobotomy 前額葉切離手術 Egas Moniz, 1935 Schizophrenia, clinical depression Connections to PFC

12 Reference PHINEAS GAGE : A Gruesome but True Story About Brain Science, by John Fleischman, 2002 Making A Good Brain Great, by Daniel G. Amen, 2007 認識你的頭腦, 洪祖培教授、邱浩彰醫師著


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