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Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology MDRS Chapel Hill, NC 9/25/09 Wendy A. Suzuki Center for Neural.

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Presentation on theme: "Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology MDRS Chapel Hill, NC 9/25/09 Wendy A. Suzuki Center for Neural."— Presentation transcript:

1 Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology MDRS Chapel Hill, NC 9/25/09 Wendy A. Suzuki Center for Neural Science New York University

2 Talk Outline Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments

3 Ventral View of Macaque Monkey Brain rs PR ER PH TE

4 24/25/32 Pi Ia Id Ig Frontal LobeTemporal LobeInsular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSdSTG TE STSv TEO 11/ DG Sub HPC 30-60% 18-29% 5-17% <5% Entorhinal Parahippocampal Perirhinal Suzuki and Amaral, 1994

5 TE/TEO 63% TF/TH 25% STSd 6% Insula 2% Frontal lobe 2% Cingulate/Retrosplenial <1% V4 2% Perirhinal Cortex Cortical Inputs to the Perirhinal Cortex

6 Dorsal area TE TF Orbital areas 11 and 13 V4/TEO Area TE Frontal area 8 and 45 Cortical Inputs to Area TE Perirhinal Parietal (LIPd)

7 24/25/32 Pi Ia Id Ig Frontal LobeTemporal LobeInsular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSdSTG TE STSv TEO 11/ DG Sub HPC 30-60% 18-29% 5-17% <5% Entorhinal Parahippocampal Perirhinal Suzuki and Amaral, 1994

8 What about the cytoarchitectonic features of these areas?

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12 24/25/32 Pi Ia Id Ig Frontal LobeTemporal LobeInsular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSdSTG TE STSv TEO 11/ DG Sub HPC 30-60% 18-29% 5-17% <5% Entorhinal Parahippocampal Perirhinal Suzuki and Amaral, 1994

13 Talk Outline Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments

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16 Pair Coding response Naya et al., 2003 Individual cell responses in area 36

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19 Probability Correct Behavioral Learning Curve and Delay Activity Over Time to Scene 653 Response (Spikes/Sec ) Baseline Activity Trials C Wirth et al., 2003

20 Object-Place Association Task Wirth et al, 2009

21 Conclusions: Pair coding neurons are built in the perirhinal cortex from the sensory input from area TE.

22 Talk Outline Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments

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24 Experiments?


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