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8. HOW REPERTOIRES OF ANTIGEN SPECIFIC RECEPTORS ARISE
DIFFERENTIATION OF B LYMPHOCYTES
DEVELOPMENT AND SELECTION OF T LYMPHOCYTES IN THYMUS
9. IMMUNE RESPONSES BASED ON T LYMPHOCYTES AND NK CELLS
9A T LYMPHOCYTES
T LYMPHOCYTES: IMPORTNAT FUNCTIONAL SUBPOPULATIONS
ANOTHER RECENTLY DISCOVERED IMPORTANT SUBPOPULATION : Th17 (somewhat similar to Th1)
9B ADHESION MOLECULES
RECEPTORS ASSOCIATED WITH TRIMERIC G-PROTEINS
PHOSPHATASES – CD45
Src KINASES (Lck, Fyn, Lyn…) REGULATION OF ACTIVITY
ReceptorLigandS (chemokines)Expression on cells CCR1 RANTES, MIP-1a, MCP- 3, MCP-4 MF, activated T, neutrophils, bazofils CCR2MCP-2, -3, -4, -5MF, activ. T, bazofils CCR3 Eotaxin, eotaxin-2, MCP- 2, -3, -4 Eosinofils, activ. T (TH2), bazofils CCR4 TARC, MDC, RANTES, MIP-1a, MCP-1 Activ. T (TH2), bazofils CCR5 RANTES, MIP-1a, MIP- 1b MF, activ. T (TH1) CCR76Ckine, MIP-3bDC, T, B CCR8I-309Activ. T (TH2), NK CCR9TECKDC, thymocytes CCR10CTACKT (skin) CCR11MCP-1Various cells CXCR1IL-8, GCP-2Neutrofils, NK CXCR2 IL-8, GCP-2, GRO, ENA-78, NAP-2 Neutrofils, NK CXCR3IP-10, Mig, I-TACActiv T (TH1), NK CXCR4SDF-1MF, T CXCR5BLCB CX3CR1FractalkineMF, activ. T, NK XCR1Lymfotaktin a, bActiv. T, NK
10. IMMUNE RESPONSES BASED ON B LYMPHOCYTES
DIFFERENTIATION OF B LYMPHOCYTES
11. ANTI-INFECTION IMMUNITY
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Cytokines Ahmad Shihada Silmi Hematologist & Immunologist IUG.
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Specific Defenses of the Host The Immune response.
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T-cell development and differentiation. T-cell diversity is generated in the thymus The TCR is a recognition unit that looks like an arm of the BCR In.
16-1 T -lymphocytes T cell receptor T – cytotoxic (CD8) cells T – helper (CD4) cells Activation of T cells.
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