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8. HOW REPERTOIRES OF ANTIGEN SPECIFIC RECEPTORS ARISE.

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Presentation on theme: "8. HOW REPERTOIRES OF ANTIGEN SPECIFIC RECEPTORS ARISE."— Presentation transcript:

1 8. HOW REPERTOIRES OF ANTIGEN SPECIFIC RECEPTORS ARISE

2 DIFFERENTIATION OF B LYMPHOCYTES

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8 DEVELOPMENT AND SELECTION OF T LYMPHOCYTES IN THYMUS

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13 9. IMMUNE RESPONSES BASED ON T LYMPHOCYTES AND NK CELLS

14 9A T LYMPHOCYTES

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17 APC!!!

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20 DENDRITIC CELLS

21 T LYMPHOCYTES: IMPORTNAT FUNCTIONAL SUBPOPULATIONS

22 ANOTHER RECENTLY DISCOVERED IMPORTANT SUBPOPULATION : Th17 (somewhat similar to Th1)

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35 9B ADHESION MOLECULES

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42 9C SIGNALING

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44 PHOSPHORYLATION!!!

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46 RECEPTORS ASSOCIATED WITH TRIMERIC G-PROTEINS

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49 PHOSPHATASES – CD45

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52 Src KINASES (Lck, Fyn, Lyn…) REGULATION OF ACTIVITY

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54 9D CYTOKINES

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62 ReceptorLigandS (chemokines)Expression on cells CCR1 RANTES, MIP-1a, MCP- 3, MCP-4 MF, activated T, neutrophils, bazofils CCR2MCP-2, -3, -4, -5MF, activ. T, bazofils CCR3 Eotaxin, eotaxin-2, MCP- 2, -3, -4 Eosinofils, activ. T (TH2), bazofils CCR4 TARC, MDC, RANTES, MIP-1a, MCP-1 Activ. T (TH2), bazofils CCR5 RANTES, MIP-1a, MIP- 1b MF, activ. T (TH1) CCR76Ckine, MIP-3bDC, T, B CCR8I-309Activ. T (TH2), NK CCR9TECKDC, thymocytes CCR10CTACKT (skin) CCR11MCP-1Various cells CXCR1IL-8, GCP-2Neutrofils, NK CXCR2 IL-8, GCP-2, GRO, ENA-78, NAP-2 Neutrofils, NK CXCR3IP-10, Mig, I-TACActiv T (TH1), NK CXCR4SDF-1MF, T CXCR5BLCB CX3CR1FractalkineMF, activ. T, NK XCR1Lymfotaktin a, bActiv. T, NK

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71 10. IMMUNE RESPONSES BASED ON B LYMPHOCYTES

72 DIFFERENTIATION OF B LYMPHOCYTES

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84 11. ANTI-INFECTION IMMUNITY

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