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Chinese Medical Journal 2011 ; 124(3) : 347-351 A preliminary study on correlation triple-phase multi -slice CT scan with histological differentiation.

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Presentation on theme: "Chinese Medical Journal 2011 ; 124(3) : 347-351 A preliminary study on correlation triple-phase multi -slice CT scan with histological differentiation."— Presentation transcript:

1 Chinese Medical Journal 2011 ; 124(3) : A preliminary study on correlation triple-phase multi -slice CT scan with histological differentiation and intratumoral microvascular/lymphatic invasion in gastric cancer

2 Preliminary (pri‘liminəri ) 初步的 Intratumoral 肿瘤内的 histological differentiation 病理分化 identified 经过鉴定 parenchymal phase 实质期 Invasion 侵犯

3 Background Many studies have shown that cancer celI diferentiation and microvascuIar invasion play a principle role in cancer progression and metastasis 。 and non—invasive imaging techniques such as CT MRI and US assessing the diferentiation and the surgical resectibility and the prognosis of cancers are now of great importance . This study aimed to explore the correlation of triple-phase multi-slice CT scan with the histological diferentiation and intratumor microvascular/lymphatic invasion of progressive gastric cancer

4 Methods The present study included 64 patients with gastric cancer . alI of whom underwent routinaI and dual-phase contrast enhancement multi-slice CT examinations of the upper abdomen before surgery . The post-operative specimens were used for determination of histologicaI differentiation,cancer celI invasion of intratumoraI microvascular/lymphatic vesseI identified by CD34 and D2-40 expression . correlations between contrast enhancement ratio(CER)of triple- phase multi-slice CT scan in gastric cancer and histologicaI diferentiation as well as intratumoraI microvascular/lymphatic invasion were compared and analyzed .

5 Materials Included in the present study were 64 cases of gastric cancer specimens surgically resected between January2006 and December 2009 in our hospita1 . They included 48 males and 16 females who ranged in age from 37 years to 80 years . The gastric cancer tumor was located in the upper stomach(fundus and cardia)in 30 cases , in the lower stomach(antrum and pylorus)in 30 cases , and in the body in 4 cases . All the Patients underwent multi—slice CT routine and dual—phase contrast enhancement examination of the upper abdomen preoperatively,and surgery was performed 3 days 一 7 days after CT examination . The postoperative specimens were routinely fixed with l0 % formalin , and HE stained to determine histological diferentiation .

6 Results There was a significant correlation between CER of triple—phase CT scan in gastric cancer and tumor histological diferentiation(P<0.05) . CER of the arterial phase in gastric cancer with intratumoral microvascular invasion was significantly higher than that without invasion : CER of the arterial-parenchymaI phase was significantly lower in gastric cancer with intratumoraI microvascular invasion than that without invasion However , CER of the parenchymal phase in gastric cancer with intratumoraI Iymphatic invasion was significantly higher than that without invasion

7 Conclusions CER of triple-phase multi- slice CT scan in gastric cancer is closely correlated with intratumoraI microvascuIar and Iymphatic invasion , and also could be used as a marker for histological diferentiation .

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