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Flow Phenomena Time of flight Entry slice phenomina Entry slice phenomina Intra-voxel dephasing Intra-voxel dephasing.

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Presentation on theme: "Flow Phenomena Time of flight Entry slice phenomina Entry slice phenomina Intra-voxel dephasing Intra-voxel dephasing."— Presentation transcript:

1 Flow Phenomena Time of flight Entry slice phenomina Entry slice phenomina Intra-voxel dephasing Intra-voxel dephasing

2 Introduction Explores artefacts Produced from nuclei that move during the acquisition of data Explores artefacts Produced from nuclei that move during the acquisition of data Flowing nuclei exhibit different contrast characteristics from their neighbouring stationary nuclei. Flowing nuclei exhibit different contrast characteristics from their neighbouring stationary nuclei. Originate primarily from nuclei in blood and CSF Originate primarily from nuclei in blood and CSF The motion causes mismapping of signals and results in artefacts known as flow motion artefacts or phase ghosting. The motion causes mismapping of signals and results in artefacts known as flow motion artefacts or phase ghosting. The cuases of flow artefact are known as flow phenomena The cuases of flow artefact are known as flow phenomena

3 The principal phenomina Time of flight Time of flight Entry slice phenomina Entry slice phenomina Intra-voxel dephasing Intra-voxel dephasing

4 Mechanisms of flow Laminar flow – flow that is at different but consistent velocities. At the centre of the lumen of the vessel is faster than at the wall. The volocity difference across the vessel is constant. Laminar flow – flow that is at different but consistent velocities. At the centre of the lumen of the vessel is faster than at the wall. The volocity difference across the vessel is constant. Turbulent flow – flow at different velocities that fluctuates randomly. Velocity difference across the vessel changes erratically. Turbulent flow – flow at different velocities that fluctuates randomly. Velocity difference across the vessel changes erratically. Vortex flow – flow that is initially laminar but then passes through a stricture or stenosis in the vessel. Flow at the centre of the lumen has a high velocity but near the walls, the flow spirals. Vortex flow – flow that is initially laminar but then passes through a stricture or stenosis in the vessel. Flow at the centre of the lumen has a high velocity but near the walls, the flow spirals. Stagnant flow – the velocity of flow slows down to a point of stagnation. It behaves like stationary tissue. Stagnant flow – the velocity of flow slows down to a point of stagnation. It behaves like stationary tissue.

5 Flow mechanisms Laminar flow stricture vortexturbulance Laminar flow (constant velocity)is termed first order motion

6 Time of flight phenomenon To produce a signal, a nucleus must receive an excitation pulse and a rephasing pulse. To produce a signal, a nucleus must receive an excitation pulse and a rephasing pulse. If a nucleus receive only an excitation pulse but not rephased it does not produce a signal. If a nucleus receive only an excitation pulse but not rephased it does not produce a signal. If a nucleus is rephased but not received an excitation pulse it does not produce a signal If a nucleus is rephased but not received an excitation pulse it does not produce a signal Stationary nuclei always receive both excitation pulse and rephasing pulse and therefore produce a signal. Stationary nuclei always receive both excitation pulse and rephasing pulse and therefore produce a signal. Flowing nuclei present in the slice for excitation may exit the slice before rephasing and therefore not produce signal. Flowing nuclei present in the slice for excitation may exit the slice before rephasing and therefore not produce signal. This is called the time of flight phenomenon This is called the time of flight phenomenon The effect of the phenomenon depends on the types of pulse sequence used. The effect of the phenomenon depends on the types of pulse sequence used.

7 Time of flight in spin echo pulse sequences In spin echo a slice is selected and a 90 0 excitation pulse and a rephasing pulse are applied. In spin echo a slice is selected and a 90 0 excitation pulse and a rephasing pulse are applied. Every slice is selectively excited and rephased. Every slice is selectively excited and rephased. Stationary nuclei wihin the slice receive both pulses and produce a signal Stationary nuclei wihin the slice receive both pulses and produce a signal Nuclei flowing perpendicular to the slice may be present for the excitation pulse, but may not for the rephasing pulse. Nuclei flowing perpendicular to the slice may be present for the excitation pulse, but may not for the rephasing pulse. They may not produce a signal They may not produce a signal Similarly new nuclei which have not received excitation pulse may be precsent for the rephasing pulse Similarly new nuclei which have not received excitation pulse may be precsent for the rephasing pulse They also not produce a signal They also not produce a signal This will result in a signal void from the nuclei, so the vessel appear dark This will result in a signal void from the nuclei, so the vessel appear dark

8 Time of flight phenomenon in spin echo slice Flowing nuclei excited rephased excited Not rephased Not excited rephased No signal

9 Factors affecting the time of flight effect Velocity of flow Velocity of flow TE TE Slice thickness Slice thickness

10 Velocity of flow At high velocity only a smaller proportion of nuclei are present for both excitation and rephasing pulses. At high velocity only a smaller proportion of nuclei are present for both excitation and rephasing pulses. As the velocity increases the time of flight effect is increased. As the velocity increases the time of flight effect is increased. At slow velocity more nuclei will be present for both excitation and rephasing pulses. At slow velocity more nuclei will be present for both excitation and rephasing pulses. Therefore, as the velocity decreases the effect of time of flight effect decreases. Therefore, as the velocity decreases the effect of time of flight effect decreases. This is called flow related enhancement This is called flow related enhancement

11 Effect of TE on TOF As the TE increases, a higher proportion of flowing nuclei have exited the slice between the excitation pulse and the rephasing pulse. Therefore with increasing TE the signal void increases. As the TE increases, a higher proportion of flowing nuclei have exited the slice between the excitation pulse and the rephasing pulse. Therefore with increasing TE the signal void increases.

12 Slice thickness & TOF For a given constant velocity a nucleus take longer time to travel through a thicker slice. For a given constant velocity a nucleus take longer time to travel through a thicker slice. Therefore the nuclei are more likely to receive both excitation and the rephasing pulse. Therefore the nuclei are more likely to receive both excitation and the rephasing pulse. So the TOF effect is less on thick slices than on thin slices. So the TOF effect is less on thick slices than on thin slices. Thick slice Thin slice signal Signal void

13 Time of flight in gradient echo pulse sequences In gradient echo a variable RF excitation pulse is followed by a gradient rephasing. In gradient echo a variable RF excitation pulse is followed by a gradient rephasing. Each slice is selectively excited by the RF pulse, but the rephasing gradient is applied to the whole body Each slice is selectively excited by the RF pulse, but the rephasing gradient is applied to the whole body So the flowing nucleus which was excited by the RF pulse is rephased by the gradient even if it has exited the slice, and produces a signal. So the flowing nucleus which was excited by the RF pulse is rephased by the gradient even if it has exited the slice, and produces a signal. In addition the short TR tend to saturate the stationary nuclei and the flowing nuclei appear to have a higher signal. In addition the short TR tend to saturate the stationary nuclei and the flowing nuclei appear to have a higher signal. Therefore in GE pulse sequences the flow signal enhancement is increased. Therefore in GE pulse sequences the flow signal enhancement is increased. So the GE sequences are said to be flow sensitive So the GE sequences are said to be flow sensitive

14 Summary Time of flight phenomina produce Time of flight phenomina produce flow related enhancement or flow related enhancement or high velocity signal loss high velocity signal loss Flow related enhancement increases as the: Flow related enhancement increases as the: Velocity of flow decreasesVelocity of flow decreases TE decreasesTE decreases Slice thichness increasesSlice thichness increases High velocity signal void increases as the: High velocity signal void increases as the: Velocity of flow increasesVelocity of flow increases TE increasesTE increases Slice thickness decreasesSlice thickness decreases

15 Entry slice phenomenon (in-flow effect) Entry slice phenomenon is related to the excitation history of the nuclei. Entry slice phenomenon is related to the excitation history of the nuclei. Nuclei that receive repeated RF pulses during the acquisition are said to be saturated or ‘beaten down’. Nuclei that receive repeated RF pulses during the acquisition are said to be saturated or ‘beaten down’. The NMV of these nuclei eventually reach an equilibrium position, and produce a signal according to the TE,TR, flip angle and contrast characteristics of the tissue. The NMV of these nuclei eventually reach an equilibrium position, and produce a signal according to the TE,TR, flip angle and contrast characteristics of the tissue. Nuclei that have not received repeated RF pulses are said to be ‘Fresh’ as their NMV has not been beaten down. Nuclei that have not received repeated RF pulses are said to be ‘Fresh’ as their NMV has not been beaten down. The signal produced by the ‘fresh’ nuclei and the ‘beaten down’ nuclei are different. The signal produced by the ‘fresh’ nuclei and the ‘beaten down’ nuclei are different.

16 Saturated and fresh spins Magnetic moments beaten down by repeated RF puses Fresh spins Satuurated spins

17 Stationary nuclei within a slice become saturated after repeated RF pulses. Stationary nuclei within a slice become saturated after repeated RF pulses. Nuclei flowing perpendicular to the slice enter the slice fresh. Nuclei flowing perpendicular to the slice enter the slice fresh. They therefore produce a different signal from the stationary signal. They therefore produce a different signal from the stationary signal. This is called entry slice phenomenon or in-flow effect (as it is more prominent in the first slice of a ‘stack’ of slices. This is called entry slice phenomenon or in-flow effect (as it is more prominent in the first slice of a ‘stack’ of slices. The slices in the middle of the stack exhibit less entry slice phenomenon ( as flowing nuclei have received more excitation pulses by the time they reach these slices) The slices in the middle of the stack exhibit less entry slice phenomenon ( as flowing nuclei have received more excitation pulses by the time they reach these slices)

18 Factors affecting the magnitude of entry slice phenomenon (ESP) TR - short TR reduces the magnitude of ESP TR - short TR reduces the magnitude of ESP Slice thickness – ESP increase with the slice thickness Slice thickness – ESP increase with the slice thickness Velocity of flow – ESP increases as the velocity of flow increases Velocity of flow – ESP increases as the velocity of flow increases Direction of flow – ( is the most important in determining the magnetude of ESP ) – next slide Direction of flow – ( is the most important in determining the magnetude of ESP ) – next slide

19 The direction may be co-current (same direction as the slice selection) or counter-current (opposite direction to the slice selection) The direction may be co-current (same direction as the slice selection) or counter-current (opposite direction to the slice selection) Co-current flow – ESP decreases rapidly in the direction of slice selection Co-current flow – ESP decreases rapidly in the direction of slice selection Counter-current flow – ESP is more prominent and may still be present deep within the slice stack Counter-current flow – ESP is more prominent and may still be present deep within the slice stack Direction of flow

20 vessel Co- current Counter -current Slices Co-current & counter current flow

21 Summary ESP increases: ESP increases: At the first slice in the stackAt the first slice in the stack When using a long TRWhen using a long TR In thin slicesIn thin slices With fast flowWith fast flow In counter-current flowIn counter-current flow

22 Intra-Voxel dephasing Gradients alter the magnetic field strength, precessional frequency and phase of nuclei. Gradients alter the magnetic field strength, precessional frequency and phase of nuclei. Nuclei flowing along a gradient rapidly accelerate or decelerate depending on the direction of flow and gradient application. Nuclei flowing along a gradient rapidly accelerate or decelerate depending on the direction of flow and gradient application. Flowing nuclei therefore either gain phase or loose phase Flowing nuclei therefore either gain phase or loose phase If a flowing nucleus is adjacent to a stationary nucleus in a voxel, there is a phase difference between the two nuclei. If a flowing nucleus is adjacent to a stationary nucleus in a voxel, there is a phase difference between the two nuclei. Therefore nuclei wihin the same voxel are out of phase with each other Therefore nuclei wihin the same voxel are out of phase with each other This will result in a reduction of total signal amplitude from the voxal. This will result in a reduction of total signal amplitude from the voxal. This is called intra-voxel dephasing. This is called intra-voxel dephasing.

23 The magnitude of intra-voxel dephasing depends on the degree of turbulence. The magnitude of intra-voxel dephasing depends on the degree of turbulence. In turbulent flow, IVD effects are irreversible. In turbulent flow, IVD effects are irreversible. In laminar flow, the IVD can be compensated for as long the velocity is constant. In laminar flow, the IVD can be compensated for as long the velocity is constant. Type of flow and IVD

24 Summary Flow affects image quality Flow affects image quality Time of flight effects give signal void or enhancement Time of flight effects give signal void or enhancement Entry slice phenomenon effects give a different signal intensity to flowing nuclei Entry slice phenomenon effects give a different signal intensity to flowing nuclei The signal intensity of the lumen is also affected by the mechanism of flow The signal intensity of the lumen is also affected by the mechanism of flow

25 Flow phenomena compensation Flowing nuclei produce a very confusing range of signal intensities. Flowing nuclei produce a very confusing range of signal intensities. Ideally, these should be compensated for, inorder to minimise their adverse effects on image quality and interpretation. Ideally, these should be compensated for, inorder to minimise their adverse effects on image quality and interpretation. There are several methods to help minimise flow artefacts. There are several methods to help minimise flow artefacts.

26 1. Gradient moment rephasing(nulling) Gradient moment rephasing compensates for the altered phase values of nuclei flowing along a gradient. Gradient moment rephasing compensates for the altered phase values of nuclei flowing along a gradient. It uses additional gradients to correct the altered phases back to their original values. It uses additional gradients to correct the altered phases back to their original values. In this way, flowing nuclei do not gain or loose phase due to the presence of the main gradient. In this way, flowing nuclei do not gain or loose phase due to the presence of the main gradient. This is performed by using slice select gradient and/or readout gradient. This is performed by using slice select gradient and/or readout gradient. The gradient alters its polarity from positive to double negative and then back to positive again. The gradient alters its polarity from positive to double negative and then back to positive again. A flowing nucleus traveling along these gradients, experiences different magnetic field strengths. A flowing nucleus traveling along these gradients, experiences different magnetic field strengths. In order to compensate altered phase values, the precessional frequency at the beginning of gradient moment rephasing must be the same as it is at the end. In order to compensate altered phase values, the precessional frequency at the beginning of gradient moment rephasing must be the same as it is at the end. The net precessional frequency and phase change must therefore be zero. The net precessional frequency and phase change must therefore be zero.

27 Gradient moment rephasing Hz Hz Hz Hz Hz Hz Hz Hz 00 Frequency of a stationary nucleus along a normal gradient Frequency of a stationary nucleus along the compensatory gradient Frequency of a flowing nucleus Phase of a flowing nucleus

28 Result of gradient movement rehasing Gradient moment rephasing reduces intra- voxel dephasing. Gradient moment rephasing reduces intra- voxel dephasing. As flowing nuclei have the same phase as stationary nuclei in the same voxel, their signals add constructively and therefore a brighter signal results. As flowing nuclei have the same phase as stationary nuclei in the same voxel, their signals add constructively and therefore a brighter signal results. Gradient momemt rephasing gives flowing nuclei a bright signal as spins are in phase. Gradient momemt rephasing gives flowing nuclei a bright signal as spins are in phase.

29 Note Gradient moment rephasing assumes a constant velocity across the gradients. Gradient moment rephasing assumes a constant velocity across the gradients. Most effective in slow laminar flow (1st order motion) Most effective in slow laminar flow (1st order motion) More effective in venous rather than arterial flow. More effective in venous rather than arterial flow. As it uses extra grdients minimum TE is increased As it uses extra grdients minimum TE is increased Fewer slices may be obtained for a given TR Fewer slices may be obtained for a given TR As flowing nuclei are bright usually used for T2 or T2* weighted images where fluid (blood & CSF) is bright anyway. As flowing nuclei are bright usually used for T2 or T2* weighted images where fluid (blood & CSF) is bright anyway.

30 Example Without GMR – shows mismapping of the flowing nuclei within the aorta (arrow) With GMR

31 Pre-saturation Pre-satuation pulses are used to nullify the signal from flowing nuclei so that the effects of entry slice and TOF phenomena are minimised. Pre-satuation pulses are used to nullify the signal from flowing nuclei so that the effects of entry slice and TOF phenomena are minimised. It delivers a 90 0 RF pulse to a volume of tissue outside the FOV. It delivers a 90 0 RF pulse to a volume of tissue outside the FOV. The flowing nuclei within the volume receives this pulse. The flowing nuclei within the volume receives this pulse. When they enter the slice stack, they receive the excitation pulse and become saturated. When they enter the slice stack, they receive the excitation pulse and become saturated. If it is fully saturated to 180 0, it has no transverse component of magnetization and produce a signal void. If it is fully saturated to 180 0, it has no transverse component of magnetization and produce a signal void.

32 Saturation volume FOV Pre-saturation RF pulse Stationay nuclei Flowing nuclei Excitation pulse vessel

33 Caution! To be effective, pre-saturation pulses should be placed between the flow and the imaging stack. To be effective, pre-saturation pulses should be placed between the flow and the imaging stack. In sagital and axial imaging it is usually placed above and below the FOV. In sagital and axial imaging it is usually placed above and below the FOV. Right and left sturation pulses are some times used in coronal imaging of chest to saturate flow from subclavion vessels. Right and left sturation pulses are some times used in coronal imaging of chest to saturate flow from subclavion vessels. Pre-saturation pulses are only useful if they are applied to tissue. Pre-saturation pulses are only useful if they are applied to tissue. If they are applied to air they are not effective. If they are applied to air they are not effective. They increase the amount of RF that is delivered to the patient, and increase heating effect. They increase the amount of RF that is delivered to the patient, and increase heating effect.

34 Caution! Pre-saturation pulses are applied around each slice just before the excitation pulse. Pre-saturation pulses are applied around each slice just before the excitation pulse. The TR, and the number of slices govern the interval between the delivery of each pr-saturation pulse. The TR, and the number of slices govern the interval between the delivery of each pr-saturation pulse. To optimise pre-saturation, use all the slices permitted for a given TR. To optimise pre-saturation, use all the slices permitted for a given TR. As pre- saturation produces a signal void, it is usually used in T1 and proton density weighted images where fluid (blood & CSF), is dark anyway. As pre- saturation produces a signal void, it is usually used in T1 and proton density weighted images where fluid (blood & CSF), is dark anyway.

35 Example -pre-saturated images With pre-saturation Artefact from flowing nuclei within aorta (without saturation) T1 weighted imaes

36 Other uses of pre-saturation Pre-saturation nullifies signal and can therefore be used to specifically eliminate certain signals. Pre-saturation nullifies signal and can therefore be used to specifically eliminate certain signals. The main uses of this are: The main uses of this are: fat and water saturationfat and water saturation to reduce aliasingto reduce aliasing

37 1. Fat & water saturation In fat hydrogen is linked to carbon and in water it is linked to oxygen. In fat hydrogen is linked to carbon and in water it is linked to oxygen. Therfore the precessional frequency of hydrogen in water and fat are different. Therfore the precessional frequency of hydrogen in water and fat are different. AT 1.5T field strength this difference is 220 Hz ( less in fat). AT 1.5T field strength this difference is 220 Hz ( less in fat). To saturate fat signal, a 90 0 pre-saturation pulse must be applied at the precessional frequency of fatt to the whole FOV. To saturate fat signal, a 90 0 pre-saturation pulse must be applied at the precessional frequency of fatt to the whole FOV. To saturate water signal, the pre-saturation pulse at the precessional frequency of water is applied to the whole FOV To saturate water signal, the pre-saturation pulse at the precessional frequency of water is applied to the whole FOV

38 220Hz Water peak Fat peak Saturation pulse Fat saturation Water saturation Fat & water saturation pulses

39 Examples Sagital T1 weighted images Without fat saturation With fat saturation Without fat saturation With fat saturation

40 T1 weighted image without water saturation T1 weighted image without water saturation T1 weighted image with water saturation T1 weighted image with water saturation

41 2. pre-saturation to prevent aliasing Aliasing is produced when anatomy exists outside the FOV. It can be reduced by pre-saturation to prevent signals from tissue outside the FOV. However there are anti-aliasing methods to prevent aliasing (discused later). Aliasing is produced when anatomy exists outside the FOV. It can be reduced by pre-saturation to prevent signals from tissue outside the FOV. However there are anti-aliasing methods to prevent aliasing (discused later).

42 Summary 1. Gradient Moment Rephasing: Uses additional gradients to correct altered phase valuesUses additional gradients to correct altered phase values Reduces artefact from intra-voxel dephasingReduces artefact from intra-voxel dephasing Gives flowing nuclei a bright signalGives flowing nuclei a bright signal Is mainly used in T2 or T2* weighted imagesIs mainly used in T2 or T2* weighted images Is most effective on slow, laminar flow within the sliceIs most effective on slow, laminar flow within the slice

43 Summary 2. Pre-saturation: Uses additional RF pulses to nullify signal from flowing nucleiUses additional RF pulses to nullify signal from flowing nuclei Reduces artefacts due to time of flight and entry slice phnomenonReduces artefacts due to time of flight and entry slice phnomenon Gives flowing nuclei a signal voidGives flowing nuclei a signal void Is mainly used in T1 weighted imagesIs mainly used in T1 weighted images Is effective on fast and slow flowIs effective on fast and slow flow Increases the RF deposition to the patientIncreases the RF deposition to the patient Can be used to nullify signal from fat or water and to reduce aliasing.Can be used to nullify signal from fat or water and to reduce aliasing.

44 END


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