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School of Psychiatry and Clinical Neurosciences. Research groups within the School Community, Culture and Mental Health Unit Unit for Research and Education.

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Presentation on theme: "School of Psychiatry and Clinical Neurosciences. Research groups within the School Community, Culture and Mental Health Unit Unit for Research and Education."— Presentation transcript:

1 School of Psychiatry and Clinical Neurosciences

2 Research groups within the School Community, Culture and Mental Health Unit Unit for Research and Education in Drugs and Alcohol Psychiatry of Old Age Psychopharmacology and Mood Disorders Neuropsychiatry Unit Alzheimer Unit / Sir James McCusker Centre Neuroepidemiology Research Unit Centre for Clinical Research in Neuropsychiatry

3 Community, Culture and Mental Health Unit Head: W/Prof Aleksandar Janca Development of a screening instrument for social & emotional wellbeing among Aboriginal people - Covers 10 domains including physical and mental health, functioning and resilience - Designed to assess Aboriginal people presenting with possible mental health problems in a variety of urban, rural and remote settings Physical health in Aboriginal people with mental illness - Based on the WA Clinical Guidelines for the Physical Care of Mental Health Consumers, with main focus on the metabolic syndrome Mental health screening among reception prisoners - Aims to assess the prevalence of mental and substance use disorders in Aboriginal and non-Aboriginal detainees being received into the WA prison system - Determine need and provide data relevant to culturally appropriate services for mentally disordered offenders

4 Unit for Research and Education in Drugs and Alcohol Head: W/Prof Gary Hulse Current studies: - Promoting smoking cessation during admissions of psychiatric patients to “smoke-free” hospitals - Subphenotypes of heroin dependence associated with treatment outcomes and genetic variants (a genome-wide association study of 2500 cases, including 897 from WA, in collaboration with Washington University, Yale University and the Queensland Institute of Medical Research) - Safety and tolerability of subcutaneous flumazenil in the treatment of benzodiazepine dependence - Biodegradability of sustained-release naltrexone implants - Liver function in patients treated with sustained-release naltrexone - Health outcomes following treatment with sustained-release naltrexone (using the WA Data Linkage System)

5 Psychopharmacology and Mood Disorders Head: Prof Sean Hood Current studies: - Serotonin and antidepressant effects in healthy volunteers - Deep brain stimulation in Tourette’s syndrome - Oxidative products as predictors of functional capacity in bipolar disorders - Emotion processing in euthymic bipolar disorder - Acute coronary syndrome & depression - Serotonin systems in anxiety disorders - Effects of acute tryptophan depletion on the tryptophan oxidative pathway New research 2011: - Deep brain stimulation in obsessive-compulsive disorder - Adrenergic receptor blockade and pain processing - SSRIs, panic disorder and hypertension

6 Neuropsychiatry Unit / Fremantle Hospital Head: W/Prof Sergio Starkstein Current studies: Assessment of neuropsychiatric disorders in patients with stroke, Parkinson’s disease and dementia - Randomised double-blind, placebo-controlled study of Nefracetam in patients with post-stroke apathy - Deficits of insights and judgement in Alzheimer’s disease - Mechanism, predictive value and impact of apathy in patients with Alzheimer’s disease and their caregivers Neuroimaging investigation of the correlates of brain function and neuropsychiatric disorders - Analysis of MRI and PET scans utilising post-processing software BRAINS2/Freesurfer

7 Neuroepidemiology Research Unit Head: Prof Vera Morgan Current studies: Pathways of risk from conception to disease (W/Prof A. Jablensky and Prof V. Morgan) - Record-linkage study comprising all births in WA e-cohort including 455,000 individuals Criminal offending and mental illness - WA linked data on 52,091 individuals Survey of High-Impact Psychosis (SHIP) - A national collaboration (Project Director: Prof V. Morgan)

8 Centre for Clinical Research in Neuropsychiatry Director: W/Prof Assen Jablensky Western Australian Family Study of Schizophrenia participants (cases, family members, controls) - Chief Investigators: Prof A. Jablensky, Prof L. Kalaydjieva, Prof J. Badcock, Dr M. Dragovic, Dr G. Price - Neurocognitive subtyping of the schizophrenia syndrome and whole- genome association study - Collaborations: Western Australian Institute of Medical Research; Australian Schizophrenia Research Bank; Wellcome Trust Consortium on Schizophrenia Endophenotypes (UK); COGENT Consortium (USA) Genetic Study of Schizophrenia in Indonesia - Phenotype data and genomic DNA from 152 affected sib-pairs, 1105 cases and 1136 controls - Chief Investigators: Prof D. Wildenauer and A/Prof S. Schwab - Collaborations: The Australian-Indonesian Schizophrenia Consortium

9 Centre for Clinical Research in Neuropsychiatry Director: W/Prof Assen Jablensky Other CCRN projects: - Cognitive pathophysiology of hallucinations (Prof J. Badcock) - Thought and communication disorders in schizophrenia (Prof J. Badcock) - Visual processing in autism (Prof M. Maybery, Prof D. Badcock, Prof J. Badcock) - Cognitive perspective on passivity experiences in schizophrenia (A/Prof F. Waters) - Sleep and cognition in psychiatric illness (A/Prof F. Waters) - Electrophysiology (event-related potentials) in schizophrenia (Dr G. Price) - Behavioural lateralisation in schizophrenia (Dr M. Dragovic)


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